2021
Inhibition of T-Cells by Cyclosporine A Reduces Macrophage Accumulation to Regulate Venous Adaptive Remodeling and Increase Arteriovenous Fistula Maturation
Matsubara Y, Kiwan G, Liu J, Gonzalez L, Langford J, Gao M, Gao X, Taniguchi R, Yatsula B, Furuyama T, Matsumoto T, Komori K, Dardik A. Inhibition of T-Cells by Cyclosporine A Reduces Macrophage Accumulation to Regulate Venous Adaptive Remodeling and Increase Arteriovenous Fistula Maturation. Arteriosclerosis Thrombosis And Vascular Biology 2021, 41: e160-e174. PMID: 33472405, PMCID: PMC7904667, DOI: 10.1161/atvbaha.120.315875.Peer-Reviewed Original ResearchConceptsVascular wall thickeningT helper type 1 (Th1) cellsSuccessful AVF maturationAVF maturationRegulatory T cellsMacrophage accumulationT cellsType 1 cellsArteriovenous fistulaVenous remodelingWall thickeningMouse aortocaval fistula modelT helper type 2T helper type 2 cellsAdaptive remodelingM2 macrophage accumulationPrimary success rateAortocaval fistula modelArteriovenous fistula maturationPreferred vascular accessAnti-inflammatory macrophagesT cell functionWild-type miceEffect of CsAType 2 cells
2019
Molecular Targets for Improving Arteriovenous Fistula Maturation and Patency.
Gorecka J, Fereydooni A, Gonzalez L, Lee SR, Liu S, Ono S, Xu J, Liu J, Taniguchi R, Matsubara Y, Gao X, Gao M, Langford J, Yatsula B, Dardik A. Molecular Targets for Improving Arteriovenous Fistula Maturation and Patency. Vascular Investigation And Therapy 2019, 2: 33-41. PMID: 31608322, PMCID: PMC6788624, DOI: 10.4103/vit.vit_9_19.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAVF maturationAVF failureArteriovenous fistulaOutward remodelingNeointimal hyperplasiaVenous wallErythropoietin-producing hepatocellular carcinoma (Eph) receptorsWall thickeningEnd-stage renal diseaseAdhesion molecule upregulationReliable vascular accessArteriovenous fistula maturationPotential treatment strategyPotential therapeutic targetPrevalence of chronicGrowth factor secretionFistula environmentFistula successExtracellular matrix remodelingRenal diseaseFistula maturationFunctional fistulaHemodialysis accessVascular accessFistula creation