2021
PD-L1 (Programmed Death Ligand 1) Regulates T-Cell Differentiation to Control Adaptive Venous Remodeling
Matsubara Y, Gonzalez L, Kiwan G, Liu J, Langford J, Gao M, Gao X, Taniguchi R, Yatsula B, Furuyama T, Matsumoto T, Komori K, Mori M, Dardik A. PD-L1 (Programmed Death Ligand 1) Regulates T-Cell Differentiation to Control Adaptive Venous Remodeling. Arteriosclerosis Thrombosis And Vascular Biology 2021, 41: 2909-2922. PMID: 34670406, PMCID: PMC8664128, DOI: 10.1161/atvbaha.121.316380.Peer-Reviewed Original ResearchConceptsPD-L1AVF maturationPD-L1 activityVenous remodelingT cellsL1 antibodyArteriovenous fistulaNude miceMouse aortocaval fistula modelEnd-stage renal diseaseT helper type 2 cellsT helper type 1 (Th1) cellsPrimary success rateSmooth muscle cell proliferationRegulatory T cellsT cell activityT-cell transferAortocaval fistula modelPreferred vascular accessVascular wall thickeningM1-type macrophagesM2-type macrophagesPotential therapeutic targetMuscle cell proliferationType 1 cells
2019
Molecular Targets for Improving Arteriovenous Fistula Maturation and Patency.
Gorecka J, Fereydooni A, Gonzalez L, Lee SR, Liu S, Ono S, Xu J, Liu J, Taniguchi R, Matsubara Y, Gao X, Gao M, Langford J, Yatsula B, Dardik A. Molecular Targets for Improving Arteriovenous Fistula Maturation and Patency. Vascular Investigation And Therapy 2019, 2: 33-41. PMID: 31608322, PMCID: PMC6788624, DOI: 10.4103/vit.vit_9_19.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAVF maturationAVF failureArteriovenous fistulaOutward remodelingNeointimal hyperplasiaVenous wallErythropoietin-producing hepatocellular carcinoma (Eph) receptorsWall thickeningEnd-stage renal diseaseAdhesion molecule upregulationReliable vascular accessArteriovenous fistula maturationPotential treatment strategyPotential therapeutic targetPrevalence of chronicGrowth factor secretionFistula environmentFistula successExtracellular matrix remodelingRenal diseaseFistula maturationFunctional fistulaHemodialysis accessVascular accessFistula creation