2022
Endothelial Cell TGF-β (Transforming Growth Factor-Beta) Signaling Regulates Venous Adaptive Remodeling to Improve Arteriovenous Fistula Patency
Taniguchi R, Ohashi Y, Lee JS, Hu H, Gonzalez L, Zhang W, Langford J, Matsubara Y, Yatsula B, Tellides G, Fahmy TM, Hoshina K, Dardik A. Endothelial Cell TGF-β (Transforming Growth Factor-Beta) Signaling Regulates Venous Adaptive Remodeling to Improve Arteriovenous Fistula Patency. Arteriosclerosis Thrombosis And Vascular Biology 2022, 42: 868-883. PMID: 35510552, PMCID: PMC9233042, DOI: 10.1161/atvbaha.122.317676.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaSMC proliferationAVF patencyCollagen densityMouse aortocaval fistula modelTGF-β receptor IArteriovenous fistula patencyAortocaval fistula modelInhibition of TGFPredetermined time pointsTGF-β inhibitionTGF-β signalingTGF-β receptorDisruption of TGFFistula patencyAVF failureWall thicknessVascular accessVenous remodelingSuccessful hemodialysisDoppler ultrasoundFistula modelReceptor IPatencyTGF
2019
Molecular Targets for Improving Arteriovenous Fistula Maturation and Patency.
Gorecka J, Fereydooni A, Gonzalez L, Lee SR, Liu S, Ono S, Xu J, Liu J, Taniguchi R, Matsubara Y, Gao X, Gao M, Langford J, Yatsula B, Dardik A. Molecular Targets for Improving Arteriovenous Fistula Maturation and Patency. Vascular Investigation And Therapy 2019, 2: 33-41. PMID: 31608322, PMCID: PMC6788624, DOI: 10.4103/vit.vit_9_19.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAVF maturationAVF failureArteriovenous fistulaOutward remodelingNeointimal hyperplasiaVenous wallErythropoietin-producing hepatocellular carcinoma (Eph) receptorsWall thickeningEnd-stage renal diseaseAdhesion molecule upregulationReliable vascular accessArteriovenous fistula maturationPotential treatment strategyPotential therapeutic targetPrevalence of chronicGrowth factor secretionFistula environmentFistula successExtracellular matrix remodelingRenal diseaseFistula maturationFunctional fistulaHemodialysis accessVascular accessFistula creation