2024
An adapted scale to measure perceived TB and HIV stigma during household contact investigation.
Armstrong-Hough M, Shelby T, Ggita J, Nangendo J, Gupta A, Davis J, Katamba A. An adapted scale to measure perceived TB and HIV stigma during household contact investigation. The International Journal Of Tuberculosis And Lung Disease 2024, 28: 433-438. PMID: 39187997, DOI: 10.5588/ijtld.23.0395.Peer-Reviewed Original ResearchConceptsHousehold contact investigationStigma ScaleTB-HIVNewly diagnosed TB patientsContact investigationCognitive interview dataHIV stigmaHealth behaviorsFactor analysisCognitive interviewsElimination of itemsInter-item covariationStandardised measuresPsychometric propertiesRandom sampleTB patientsInterview dataHIVIdentifying opportunitiesStigmaHousehold contactsItemsScoresHouseholdsCovariates
2023
A user-centred implementation strategy for tuberculosis contact investigation in Uganda: protocol for a stepped-wedge, cluster-randomised trial
Katamba A, Gupta A, Turimumahoro P, Ochom E, Ggita J, Nakasendwa S, Nanziri L, Musinguzi J, Hennein R, Sekadde M, Hanrahan C, Byaruhanga R, Yoeli E, Turyahabwe S, Cattamanchi A, Dowdy D, Haberer J, Armstrong-Hough M, Kiwanuka N, Davis J. A user-centred implementation strategy for tuberculosis contact investigation in Uganda: protocol for a stepped-wedge, cluster-randomised trial. BMC Public Health 2023, 23: 1568. PMID: 37592314, PMCID: PMC10436440, DOI: 10.1186/s12889-023-16510-0.Peer-Reviewed Original ResearchConceptsContact investigationClinical effectiveness outcomesPrimary implementation outcomeTB contact investigationTB preventative therapyTB treatment initiationTimely TB diagnosisTrial registrationThe trialTuberculosis contact investigationCluster-randomised trialHigh-burden settingsImplementation-effectiveness trialEvidence-based interventionsUganda National CouncilWorld Health OrganizationProportion of contactsTB evaluationPeer-reviewed journalsMiddle-income countriesTreatment initiationTB diagnosisPreventative therapyUndiagnosed personsInfectious deathSputum samplesSex modifies the risk of HIV-associated obstructive lung disease in Ugandans postpneumonia
Abelman R, Fitzpatrick J, Zawedde J, Sanyu I, Byanyima P, Kaswabuli S, Musisi E, Hsieh J, Gardner K, Zhang M, Byanova K, Sessolo A, Hunt P, Lalitha R, Davis J, Crothers K, Worodria W, Huang L. Sex modifies the risk of HIV-associated obstructive lung disease in Ugandans postpneumonia. AIDS 2023, 37: 1683-1692. PMID: 37352494, PMCID: PMC10527596, DOI: 10.1097/qad.0000000000003626.Peer-Reviewed Original ResearchConceptsObstructive lung diseaseLung diseaseLung functionAbnormal lung functionMultivariable regression modelsWarrants further studyCommon comorbiditiesExpiratory volumeSpirometric abnormalitiesSmoking statusSpirometric testingTB statusVital capacitySex modifiesStratified analysisHIVWomenDiseaseComorbiditiesMenSexFurther studiesGreater degreeRiskTuberculosisFrequency of HIV serodifferent couples within TB-affected households in a setting with a high burden of HIV-associated TB
Anguzu G, Gupta A, Ochom E, Tseng A, Zhang M, Barnabas R, Flaxman A, Katamba A, Davis J, Ross J. Frequency of HIV serodifferent couples within TB-affected households in a setting with a high burden of HIV-associated TB. BMC Infectious Diseases 2023, 23: 388. PMID: 37296396, PMCID: PMC10251627, DOI: 10.1186/s12879-023-08365-y.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusUganda AIDS Indicator SurveyHIV prevention servicesIndex participantsContact investigationGeneral populationPrevention servicesFrequency of HIVProportion of HIVRisk of HIVSelf-reported HIV statusHIV testing resultsHIV-serodifferent couplesHousehold contact investigationTB contact investigationAIDS Indicator SurveyCross-sectional trialCommunity health workersIndex partnerSerodifferent couplesTB evaluationHousehold contactsHomes of participantsHIV statusImmunodeficiency virus
2022
Feasibility and Sensitivity of Saliva GeneXpert MTB/RIF Ultra for Tuberculosis Diagnosis in Adults in Uganda
Byanyima P, Kaswabuli S, Musisi E, Nabakiibi C, Zawedde J, Sanyu I, Sessolo A, Andama A, Worodria W, Huang L, Davis JL. Feasibility and Sensitivity of Saliva GeneXpert MTB/RIF Ultra for Tuberculosis Diagnosis in Adults in Uganda. Microbiology Spectrum 2022, 10: e00860-22. PMID: 36154664, PMCID: PMC9603304, DOI: 10.1128/spectrum.00860-22.Peer-Reviewed Original ResearchConceptsGeneXpert MTB/RIF UltraMTB/RIF UltraXpert UltraTB diagnosisMolecular testingHigh TB burden settingsCulture-confirmed TB casesSaliva samplesTB diagnostic evaluationActive tuberculosis diseaseProspective observational studyActive TB diagnosisCause of morbidityAcid-fast bacilliComposite reference standardReference standardCase-only studySingle saliva sampleWorld Health OrganizationSpot sputumTB evaluationConsecutive adultsTB casesBurden settingsOutpatient departmentAssessing a norming intervention to promote acceptance of HIV testing and reduce stigma during household tuberculosis contact investigation: protocol for a cluster-randomised trial
Armstrong-Hough M, Ggita J, Gupta AJ, Shelby T, Nangendo J, Ayen DO, Davis JL, Katamba A. Assessing a norming intervention to promote acceptance of HIV testing and reduce stigma during household tuberculosis contact investigation: protocol for a cluster-randomised trial. BMJ Open 2022, 12: e061508. PMID: 35613785, PMCID: PMC9134160, DOI: 10.1136/bmjopen-2022-061508.Peer-Reviewed Original ResearchConceptsCommunity health workersHIV testingHIV test uptakeHIV status awarenessHome HIV testingHousehold contactsContact investigationTB stigmaTest uptakeHIV stigmaPublic Health Institutional Review BoardHealth Institutional Review BoardTB contact investigationTuberculosis contact investigationCluster-randomised trialHousehold tuberculosis contact investigationPublic health facilitiesVerbal informed consentHuman Investigation CommitteeMakerere University SchoolInstitutional review boardUganda National CouncilProportion of contactsHome HIVStatus awareness
2021
Multicomponent Strategy with Decentralized Molecular Testing for Tuberculosis
Cattamanchi A, Reza T, Nalugwa T, Adams K, Nantale M, Oyuku D, Nabwire S, Babirye D, Turyahabwe S, Tucker A, Sohn H, Ferguson O, Thompson R, Shete P, Handley M, Ackerman S, Joloba M, Moore D, Davis J, Dowdy D, Fielding K, Katamba A. Multicomponent Strategy with Decentralized Molecular Testing for Tuberculosis. New England Journal Of Medicine 2021, 385: 2441-2450. PMID: 34936740, PMCID: PMC9212879, DOI: 10.1056/nejmoa2105470.Peer-Reviewed Original ResearchConceptsSame-day treatmentSame-day diagnosisHealth centersMolecular testingTuberculosis testingHuman immunodeficiency virus (HIV) infectionDiagnostic strategiesImmunodeficiency virus infectionCommunity health centersCluster-randomized trialTreatment of tuberculosisSecondary outcomesMore patientsPrimary outcomePrompt diagnosisRoutine careEligible adultsIntervention groupIntervention periodHigh burdenVirus infectionIntervention centersControl groupPatientsTuberculosis
2018
Feasibility, Acceptability, and Adoption of Digital Fingerprinting During Contact Investigation for Tuberculosis in Kampala, Uganda: A Parallel-Convergent Mixed-Methods Analysis
White EB, Meyer AJ, Ggita JM, Babirye D, Mark D, Ayakaka I, Haberer JE, Katamba A, Armstrong-Hough M, Davis JL. Feasibility, Acceptability, and Adoption of Digital Fingerprinting During Contact Investigation for Tuberculosis in Kampala, Uganda: A Parallel-Convergent Mixed-Methods Analysis. Journal Of Medical Internet Research 2018, 20: e11541. PMID: 30442637, PMCID: PMC6265600, DOI: 10.2196/11541.Peer-Reviewed Original ResearchConceptsTechnology Acceptance Model 2Digital fingerprintingDigital fingerprintUnique patient identificationData integrityFingerprint captureSoftware leadFingerprint scannerPatient identificationHardware failureDigital technologiesBiometricsModest clusteringClusteringSocial imageTechnologyHousehold tuberculosis contact investigationRobust covariance estimatorPotential solutionsActual useGuide improvementFrameworkHardwareIndividual identificationTemporal characteristicsPatterns of usage and preferences of users for tuberculosis-related text messages and voice calls in Uganda
Ggita JM, Ojok C, Meyer AJ, Farr K, Shete PB, Ochom E, Turimumahoro P, Babirye D, Mark D, Dowdy D, Ackerman S, Armstrong-Hough M, Nalugwa T, Ayakaka I, Moore D, Haberer JE, Cattamanchi A, Katamba A, Davis JL. Patterns of usage and preferences of users for tuberculosis-related text messages and voice calls in Uganda. The International Journal Of Tuberculosis And Lung Disease 2018, 22: 530-536. PMID: 29663958, PMCID: PMC6350252, DOI: 10.5588/ijtld.17.0521.Peer-Reviewed Original ResearchConceptsClinic attendeesHousehold contactsTB patientsClinic visitsClinic patientsMHealth interventionsTuberculosisMobile phone accessHealth communicationPatientsUrban KampalaMost contactPhone accessPhone sharingLittle informationAttendeesText messagesPatterns of usageShort messaging service (SMS) messagesUgandaCentral UgandaVisitsRecipients
2017
Drop-out from the tuberculosis contact investigation cascade in a routine public health setting in urban Uganda: A prospective, multi-center study
Armstrong-Hough M, Turimumahoro P, Meyer AJ, Ochom E, Babirye D, Ayakaka I, Mark D, Ggita J, Cattamanchi A, Dowdy D, Mugabe F, Fair E, Haberer JE, Katamba A, Davis JL. Drop-out from the tuberculosis contact investigation cascade in a routine public health setting in urban Uganda: A prospective, multi-center study. PLOS ONE 2017, 12: e0187145. PMID: 29108007, PMCID: PMC5673209, DOI: 10.1371/journal.pone.0187145.Peer-Reviewed Original ResearchConceptsHousehold contact investigationNational TB ProgrammeContact investigationTB evaluationActive TBHealth workersPatient householdsMulti-center observational studyIndex TB patientsTB contact investigationLay health workersTuberculosis contact investigationMulti-center studyRoutine public health settingPublic health settingsTB patientsTB programsEligible contactsTuberculosis unitProgrammatic settingsRisk factorsIndex householdsIndex patientsObservational studyRisk contactsIdentifying barriers to and facilitators of tuberculosis contact investigation in Kampala, Uganda: a behavioral approach
Ayakaka I, Ackerman S, Ggita JM, Kajubi P, Dowdy D, Haberer JE, Fair E, Hopewell P, Handley MA, Cattamanchi A, Katamba A, Davis JL. Identifying barriers to and facilitators of tuberculosis contact investigation in Kampala, Uganda: a behavioral approach. Implementation Science 2017, 12: 33. PMID: 28274245, PMCID: PMC5343292, DOI: 10.1186/s13012-017-0561-4.Peer-Reviewed Original ResearchConceptsLay health workersTB contact investigationTuberculosis contact investigationContact investigationTB patientsHousehold contactsBackgroundThe World Health OrganizationIndex TB patientsHigh-burden countriesHousehold tuberculosis contact investigationHealth center staffHealth care workersWorld Health OrganizationFocus group discussionsScreening visitCross-sectional qualitative dataRelevant intervention functionsIndex patientsHealth workersRisk contactsPatientsTargeted interventionsClinicHealth OrganizationConclusionsThe use
2015
Transcriptional Adaptation of Drug-tolerant Mycobacterium tuberculosis During Treatment of Human Tuberculosis
Walter ND, Dolganov GM, Garcia BJ, Worodria W, Andama A, Musisi E, Ayakaka I, Van TT, Voskuil MI, de Jong BC, Davidson RM, Fingerlin TE, Kechris K, Palmer C, Nahid P, Daley CL, Geraci M, Huang L, Cattamanchi A, Strong M, Schoolnik GK, Davis JL. Transcriptional Adaptation of Drug-tolerant Mycobacterium tuberculosis During Treatment of Human Tuberculosis. The Journal Of Infectious Diseases 2015, 212: 990-998. PMID: 25762787, PMCID: PMC4548467, DOI: 10.1093/infdis/jiv149.Peer-Reviewed Original ResearchConceptsDrug-tolerant bacilliDrug exposureDrug-susceptible pulmonary tuberculosisDrug-tolerant Mycobacterium tuberculosisDrug-susceptible Mycobacterium tuberculosisMycobacterium tuberculosisTuberculosis treatment regimensInitial drug exposureReverse transcription-polymerase chain reactionMessenger RNA expressionM. tuberculosis gene expressionDrug efflux pumpsSerial sputaPulmonary tuberculosisTreatment initiationNovel drug targetsTreatment regimensPolymerase chain reactionToxin-antitoxin genesHuman tuberculosisRate of declineDrug responsivenessStress signatureMarked downregulationDrug tolerance