Liubin Yang, MD, PhD, FACOG
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About
Research
Publications
Featured Publications
Comparison of Female Ovarian Reserve Before vs After COVID-19 Vaccination
Yang L, Neal S, Lee T, Chou A, Schutt A, Gibbons W. Comparison of Female Ovarian Reserve Before vs After COVID-19 Vaccination. JAMA Network Open 2023, 6: e2318804. PMID: 37326996, PMCID: PMC10276301, DOI: 10.1001/jamanetworkopen.2023.18804.Peer-Reviewed Original ResearchMachine learning in time-lapse imaging to differentiate embryos from young vs old mice†
Yang L, Leynes C, Pawelka A, Lorenzo I, Chou A, Lee B, Heaney J. Machine learning in time-lapse imaging to differentiate embryos from young vs old mice†. Biology Of Reproduction 2024, 110: 1115-1124. PMID: 38685607, PMCID: PMC11180621, DOI: 10.1093/biolre/ioae056.Peer-Reviewed Original ResearchMaternal agePreimplantation genetic testingMorphokinetic parameters of embryosEarly embryo developmentMaternal miceNo significant differenceEmbryo transferTime-lapse microscopyGenetic testingAge-related phenotypesHuman embryosYoung donorsSignificant differenceNon-invasive approachEmbryo developmentCleavage stagesYounger counterpartsMiceNon-invasive technologyEmbryosAged embryosPhenotypeAgeTime-lapse imagingMorphokineticsDevelopment of a dynamic machine learning algorithm to predict clinical pregnancy and live birth rate with embryo morphokinetics
Yang L, Peavey M, Kaskar K, Chappell N, Zhu L, Devlin D, Valdes C, Schutt A, Woodard T, Zarutskie P, Cochran R, Gibbons W. Development of a dynamic machine learning algorithm to predict clinical pregnancy and live birth rate with embryo morphokinetics. F&S Reports 2022, 3: 116-123. PMID: 35789724, PMCID: PMC9250114, DOI: 10.1016/j.xfre.2022.04.004.Peer-Reviewed Original ResearchClinical pregnancy ratePregnancy rateClinical pregnancyAcademic fertility clinicRetrospective cohort analysisLive birth rateTertiary hospital settingLive birth outcomesPositive predictive valueBirth outcomesCohort analysisHospital settingFertility clinicsPredictive valueSecondary analysisPregnancyEmbryo morphokineticsBirth rateMorphokineticsTime-lapse microscopySimilar resultsPatientsClinicDNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias
Yang L, Rodriguez B, Mayle A, Park H, Lin X, Luo M, Jeong M, Curry C, Kim S, Ruau D, Zhang X, Zhou T, Zhou M, Rebel V, Challen G, Göttgens B, Lee J, Rau R, Li W, Goodell M. DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias. Cancer Cell 2016, 30: 363-365. PMID: 27505680, DOI: 10.1016/j.ccell.2016.07.015.Peer-Reviewed Original Research
2024
Dose-dependent effects of Dnmt3a in an inducible murine model of Kras(G12D)-driven leukemia.
Rogers JH, Rosen A, Reyes JM, Ketkar S, Conneely SE, Gupta R, Yang L, Miller MB, Medrano G, Aguilar R, Uchenda N, Goodell MA, Rau RE. Dose-dependent effects of Dnmt3a in an inducible murine model of Kras(G12D)-driven leukemia. Exp Hematol 2024, 135: 104248. PMID: 38834136, DOI: 10.1016/j.exphem.2024.104248.Peer-Reviewed Original Research
2023
Small Bowel Obstruction in Postpartum Vaginal Delivery due to Prior Abdominal Adhesions Case Report
Yang L, Kao L. Small Bowel Obstruction in Postpartum Vaginal Delivery due to Prior Abdominal Adhesions Case Report. Case Reports In Obstetrics And Gynecology 2023, 2023: 6563205. PMID: 37025389, PMCID: PMC10072967, DOI: 10.1155/2023/6563205.Peer-Reviewed Case Reports and Technical NotesSmall bowel obstructionUncomplicated vaginal deliveryVaginal deliveryBowel obstructionIntestinal obstructionInitial abdominal X-rayComputed tomography abdomenNonspecific abdominal painAbdominal X-rayPrior appendectomyTomography abdomenAbdominal painMultiparous womenCT abdomenSurgical repairAppendectomy surgeryExam findingsCase reportRisk factorsObstructionAbdomenDeliveryAppendectomyPainSurgery
2021
Fetal programming of polycystic ovary syndrome: Effects of androgen exposure on prenatal ovarian development
Barsky M, Merkison J, Hosseinzadeh P, Yang L, Bruno-Gaston J, Dunn J, Gibbons W, Blesson C. Fetal programming of polycystic ovary syndrome: Effects of androgen exposure on prenatal ovarian development. The Journal Of Steroid Biochemistry And Molecular Biology 2021, 207: 105830. PMID: 33515680, PMCID: PMC8056856, DOI: 10.1016/j.jsbmb.2021.105830.Peer-Reviewed Original ResearchConceptsGene expressionPolycystic ovary syndromeOvarian developmentDifferential gene expressionFetal gonadal developmentDownregulated genesTranscriptional pathwaysCandidate genesMitochondrial studiesMitochondrial oxygen consumptionProton leakOvary syndromeGonadal developmentMitochondrial functionFetal programmingMitochondrial ultrastructureStrong hereditary componentMitochondrial dysfunctionMitochondrial efficiencyMitochondriaAndrogen exposureGenesInheritance patternOocyte maturationAndrogen programming
2020
Embryos from polycystic ovary syndrome patients with hyperandrogenemia reach morula stage faster than controls
Chappell N, Barsky M, Shah J, Peavey M, Yang L, Sangi-Haghpeykar H, Gibbons W, Blesson C. Embryos from polycystic ovary syndrome patients with hyperandrogenemia reach morula stage faster than controls. F&S Reports 2020, 1: 125-132. PMID: 34223228, PMCID: PMC8244380, DOI: 10.1016/j.xfre.2020.05.006.Peer-Reviewed Original ResearchPolycystic ovary syndromeHyperandrogenic polycystic ovary syndromeHigher miscarriage rateMiscarriage rateBody mass index-matched patientsPolycystic ovary syndrome patientsAcademic fertility clinicRetrospective cohort analysisTertiary hospital settingObstetric outcomesRotterdam criteriaControl patientsOvary syndromeAltered fertilitySyndrome patientsCohort analysisHospital settingBlastulation ratePatientsOvarian folliclesFertility clinicsEmbryo morphokineticsEarly embryo developmentWomenFertilization rate
2015
Long Non-Coding RNAs Control Hematopoietic Stem Cell Function
Luo M, Jeong M, Sun D, Park H, Rodriguez B, Xia Z, Yang L, Zhang X, Sheng K, Darlington G, Li W, Goodell M. Long Non-Coding RNAs Control Hematopoietic Stem Cell Function. Cell Stem Cell 2015, 16: 426-438. PMID: 25772072, PMCID: PMC4388783, DOI: 10.1016/j.stem.2015.02.002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasic Helix-Loop-Helix Transcription FactorsBinding SitesBone Marrow CellsCell DifferentiationCell LineageCell Self RenewalCells, CulturedDNA (Cytosine-5-)-MethyltransferasesDNA MethylationDNA Methyltransferase 3AEpigenesis, GeneticGene Expression ProfilingGene Expression Regulation, DevelopmentalHematopoietic Stem CellsHigh-Throughput Nucleotide SequencingMiceMice, Inbred StrainsMice, KnockoutRNA, Long NoncodingRNA, Small InterferingConceptsHematopoietic stem cellsLong non-coding RNAsNon-coding RNAsLineage commitmentKey hematopoietic transcription factorsUnique gene expression programProtein-coding genesHematopoietic stem cell functionCell fate decisionsGene expression programsHematopoietic transcription factorsStem cell functionGenetic circuitryDifferentiated lineagesExpression programsFate decisionsLncRNA genesUnannotated lncRNAsDNA methylationEpigenetic featuresTranscription factorsHSC functionDeep sequencingGene expressionRegulated expressionDNMT3A in haematological malignancies
Yang L, Rau R, Goodell M. DNMT3A in haematological malignancies. Nature Reviews Cancer 2015, 15: 152-165. PMID: 25693834, PMCID: PMC5814392, DOI: 10.1038/nrc3895.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHaematopoietic stem cell differentiationStem cell differentiationStem cell programAberrant DNA methylationDominant negative inhibitorImportant biological relationshipsDifferentiated lineagesHistone methyltransferasesDNA methyltransferasesRegulatory domainDNA methylationMechanistic functionGene expressionHSC progenyMethyltransferase 3AImportant new targetHSC expansionCell differentiationUnique mutational profileDNMT3ACell programHuman HSCsStem cellsEnzymatic activityMutations
Academic Achievements & Community Involvement
Clinical Care
Overview
Liubin Yang, MD, PhD, a subspecialist in reproductive endocrinology and infertility, is dedicated to helping individuals and couples build their families. She is board certified in obstetrics and gynecology and board eligible in reproductive endocrinology and infertility by the American Board of Obstetrics and Gynecology.
As an instructor in obstetrics, gynecology, and reproductive sciences at Yale School of Medicine, Dr. Yang's research focuses on gene therapy for primary ovarian insufficiency (a condition where the ovaries stop functioning normally before age 40), ovarian aging, and genetic determinants of primary ovarian insufficiency/diminished ovarian reserve. Her research incorporates advanced techniques such as machine learning to improve outcomes in reproductive medicine. Through this research, Dr. Yang aims to enhance the understanding and treatment of infertility, providing hope and options for those seeking to grow their families.
Dr. Yang completed her medical degree, doctoral degree in molecular and human genetics, residency in obstetrics and gynecology, and fellowship in reproductive endocrinology and infertility at Baylor College of Medicine.
Clinical Specialties
Reproductive Endocrinology & Infertility
Fact Sheets
Polycystic Kidney Disease (PKD)
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Obstetrics, Gynecology & Reproductive Sciences
Yale School of Medicine, 310 Cedar Street
New Haven, CT 06510
United States
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