2014
Ultrasound-enhanced ocular delivery of dexamethasone sodium phosphate: an in vivo study
Nabili M, Shenoy A, Chawla S, Mahesh S, Liu J, Geist C, Zderic V. Ultrasound-enhanced ocular delivery of dexamethasone sodium phosphate: an in vivo study. Journal Of Therapeutic Ultrasound 2014, 2: 6. PMID: 24921047, PMCID: PMC4036608, DOI: 10.1186/2050-5736-2-6.Peer-Reviewed Original ResearchDexamethasone sodium phosphateAqueous humor samplesUnique anatomyDrug concentrationsSham-treated samplesVivo studiesOcular drug deliveryEye cupRabbit modelClinical settingAnatomical barriersOcular drugsHistological analysisOphthalmic drugsSodium phosphateResultsAn increaseCorneaEpithelial disorganizationEffective drug deliveryDrug deliveryOcular deliveryDrugsUltrasoundDeliveryMin
2012
Focused ultrasound facilitated thermo-chemotherapy for targeted retinoblastoma treatment: A modeling study
Wang S, Mahesh SP, Liu J, Geist C, Zderic V. Focused ultrasound facilitated thermo-chemotherapy for targeted retinoblastoma treatment: A modeling study. Experimental Eye Research 2012, 100: 17-25. PMID: 22564972, DOI: 10.1016/j.exer.2012.04.009.Peer-Reviewed Original ResearchConceptsFocused ultrasoundType of treatmentVision preservationRetinoblastoma treatmentIntraocular tumorsTreatment paradigmRabbit eyesTumor areaEarly detectionTumorsVivo studiesRetinoblastomaHyperthermic temperature rangeCommon typeTreatmentDrug deliveryFUS parametersUltrasoundEye structuresHyperthermiaViable optionThermo-chemotherapyDeliveryTherapy