2014
Ultrasound-enhanced ocular delivery of dexamethasone sodium phosphate: an in vivo study
Nabili M, Shenoy A, Chawla S, Mahesh S, Liu J, Geist C, Zderic V. Ultrasound-enhanced ocular delivery of dexamethasone sodium phosphate: an in vivo study. Journal Of Therapeutic Ultrasound 2014, 2: 6. PMID: 24921047, PMCID: PMC4036608, DOI: 10.1186/2050-5736-2-6.Peer-Reviewed Original ResearchDexamethasone sodium phosphateAqueous humor samplesUnique anatomyDrug concentrationsSham-treated samplesVivo studiesOcular drug deliveryEye cupRabbit modelClinical settingAnatomical barriersOcular drugsHistological analysisOphthalmic drugsSodium phosphateResultsAn increaseCorneaEpithelial disorganizationEffective drug deliveryDrug deliveryOcular deliveryDrugsUltrasoundDeliveryMin
2013
Ultrasound-Enhanced Delivery of Antibiotics and Anti-Inflammatory Drugs Into the Eye
Nabili M, Patel H, Mahesh SP, Liu J, Geist C, Zderic V. Ultrasound-Enhanced Delivery of Antibiotics and Anti-Inflammatory Drugs Into the Eye. Ultrasound In Medicine & Biology 2013, 39: 638-646. PMID: 23415283, PMCID: PMC3770302, DOI: 10.1016/j.ultrasmedbio.2012.11.010.Peer-Reviewed Original ResearchConceptsOphthalmic drugsLong-term survival studiesSodium fluoresceinAnti-inflammatory drugsTreatment parameter combinationUltrasound-enhanced deliveryTopical administrationHistologic analysisSurvival studiesCorneaCorneal permeabilityDexamethasoneEpithelial layerTherapeutic drugsRabbit corneaStatistical significanceDrug dexamethasoneDrugsTobramycinUltrasoundEyesDeliveryFuture investigationsAdministrationDrug delivery
2012
Focused ultrasound facilitated thermo-chemotherapy for targeted retinoblastoma treatment: A modeling study
Wang S, Mahesh SP, Liu J, Geist C, Zderic V. Focused ultrasound facilitated thermo-chemotherapy for targeted retinoblastoma treatment: A modeling study. Experimental Eye Research 2012, 100: 17-25. PMID: 22564972, DOI: 10.1016/j.exer.2012.04.009.Peer-Reviewed Original ResearchConceptsFocused ultrasoundType of treatmentVision preservationRetinoblastoma treatmentIntraocular tumorsTreatment paradigmRabbit eyesTumor areaEarly detectionTumorsVivo studiesRetinoblastomaHyperthermic temperature rangeCommon typeTreatmentDrug deliveryFUS parametersUltrasoundEye structuresHyperthermiaViable optionThermo-chemotherapyDeliveryTherapy
2010
Surface Acoustic Wave Devices for Ocular Drug Delivery
Ghahremani M, Nabili M, Mahesh S, Liu J, Belyea D, Geist C, Zderic V, Zaghloul M. Surface Acoustic Wave Devices for Ocular Drug Delivery. 2010, 872-875. DOI: 10.1109/ultsym.2010.5935970.Peer-Reviewed Original ResearchSurface acoustic wave devicesAcoustic wave devicesWave devicesDrug deliveryNovel surface acoustic wave deviceCOMSOL Multiphysics programDifferent force valuesOcular drug deliveryMEMS technologyDrug delivery methodsDrug delivery devicesAcoustic streamingNovel drug delivery methodsElectronic controlDevicesDelivery methodsDelivery devicesModeling resultsForce valuesDeliveryPrecise amountBetter clinical outcomesStreamingClinical outcomesDrug regiments