2008
PKC-Induced Intracellular Trafficking of CaV2 Precedes Its Rapid Recruitment to the Plasma Membrane
Zhang Y, Helm JS, Senatore A, Spafford JD, Kaczmarek LK, Jonas EA. PKC-Induced Intracellular Trafficking of CaV2 Precedes Its Rapid Recruitment to the Plasma Membrane. Journal Of Neuroscience 2008, 28: 2601-2612. PMID: 18322103, PMCID: PMC2830008, DOI: 10.1523/jneurosci.4314-07.Peer-Reviewed Original ResearchConceptsProtein kinase CActivation of PKCPlasma membraneGrowth conesLatrunculin BIntracellular traffickingActin polymerizationIntact microtubulesIntact actinKinase CChannel insertionPKC activationIon channelsMicrotubule polymerizationRapid recruitmentOrganellesLamellipodiumSubunitsMicrotubulesActinMembraneActivationRecruitmentCone terminalsNew sites
1994
Transient changes in intracellular calcium associated with a prolonged increase in excitability in neurons of Aplysia californica
Fisher T, Levy S, Kaczmarek L. Transient changes in intracellular calcium associated with a prolonged increase in excitability in neurons of Aplysia californica. Journal Of Neurophysiology 1994, 71: 1254-1257. PMID: 8201416, DOI: 10.1152/jn.1994.71.3.1254.Peer-Reviewed Original ResearchConceptsIntracellular calcium levelsBag cell neuronsCalcium levelsSpontaneous firingCell neuronsIntracellular calciumAction potentialsTransient elevationBasal intracellular calcium levelsLong-duration action potentialsBasal calcium levelsFree calcium ion concentrationTriggers calcium releaseCalcium-sensitive microelectrodesAplysia californicaIndividual action potentialsAfferent stimulationAfferent inputAfterdischargesProlonged increaseCalcium releaseCalcium ion concentrationNeuronsBiphasic patternPrimary cultures