2006
Modulation of Kv3.1b Potassium Channel Phosphorylation in Auditory Neurons by Conventional and Novel Protein Kinase C Isozymes*
Song P, Kaczmarek LK. Modulation of Kv3.1b Potassium Channel Phosphorylation in Auditory Neurons by Conventional and Novel Protein Kinase C Isozymes*. Journal Of Biological Chemistry 2006, 281: 15582-15591. PMID: 16595659, DOI: 10.1074/jbc.m512866200.Peer-Reviewed Original ResearchConceptsAuditory neuronsMNTB neuronsTrapezoid bodyBrief high-frequency electrical stimulationProtein kinase CMetabotropic glutamate receptor activationHigh-frequency electrical stimulationBasal phosphorylationGlutamate receptor activationHigh-frequency stimulationFrequency electrical stimulationHigh-frequency firingMature nervous systemKv3.1 potassium channelNeuronal abilityBrainstem slicesMedial nucleusFrequency stimulationAuditory brainstemFrequency firingConventional protein kinase CPharmacological activationNervous systemElectrical stimulationPKC isozymes
2001
Formation, Maintenance, and Plasticity of Chemical Synapses
B.Levitan I, Kaczmarek L. Formation, Maintenance, and Plasticity of Chemical Synapses. 2001, 467-506. DOI: 10.1093/oso/9780195145236.003.0018.Peer-Reviewed Original ResearchNervous systemSynaptic connectionsFormation of synapsesAdult nervous systemSpecific synaptic connectionsImmature neuronsSynaptic contactsAdult neuronsMature neuronsElectrical stimulationSynaptic plasticityNeuronal formBrain functionChemical synapsesNeuronsElectrical activityNeurite elongationSynaptogenesisSynapsesProperties of cells
2000
Activation of a Ca2+‐permeable cation channel produces a prolonged attenuation of intracellular Ca2+ release in Aplysia bag cell neurones
Magoski N, Knox R, Kaczmarek L. Activation of a Ca2+‐permeable cation channel produces a prolonged attenuation of intracellular Ca2+ release in Aplysia bag cell neurones. The Journal Of Physiology 2000, 522: 271-283. PMID: 10639103, PMCID: PMC2269759, DOI: 10.1111/j.1469-7793.2000.t01-2-00271.x.Peer-Reviewed Original ResearchConceptsVoltage-gated Ca2Non-selective cation channelsRefractory periodCation channelsElectrical stimulationFree salineAbility of nifedipinePresence of nifedipinePresence of TTXIntact abdominal gangliaProlonged refractory periodOnset of refractorinessAfferent inputBrief synaptic stimulationHigh external potassiumPermeable cation channelIntracellular calciumAbdominal ganglionExtracellular Ca2Synaptic stimulationAfterdischargesNormal responseIntracellular Ca2Intracellular storesRepeated stimulation
1996
Ionic Currents Underlying Developmental Regulation of Repetitive Firing in Aplysia Bag Cell Neurons
Nick T, Kaczmarek L, Carew T. Ionic Currents Underlying Developmental Regulation of Repetitive Firing in Aplysia Bag Cell Neurons. Journal Of Neuroscience 1996, 16: 7583-7598. PMID: 8922415, PMCID: PMC6579091, DOI: 10.1523/jneurosci.16-23-07583.1996.Peer-Reviewed Original ResearchConceptsBag cell neuronsRepetitive firingCell neuronsEgg-laying behaviorJuvenile neuronsTetraethyl ammonium chlorideDevelopmental regulationSpecific ionic currentsAplysia bag cell neuronsAfterdischargesElectrical stimulationVariety of stimuliDevelopmental controlNeuronal systemsProlonged depolarizationBehavioral effectsNeuronsIonic currentsDevelopmental mechanismsSelective regulationAdultsAplysia californicaFiringRegulationDepolarization
1993
The peptide FMRFa terminates a discharge in Aplysia bag cell neurons by modulating calcium, potassium, and chloride conductances
Fisher T, Lin C, Kaczmarek L. The peptide FMRFa terminates a discharge in Aplysia bag cell neurons by modulating calcium, potassium, and chloride conductances. Journal Of Neurophysiology 1993, 69: 2164-2173. PMID: 7688803, DOI: 10.1152/jn.1993.69.6.2164.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAplysiaCalcium ChannelsCells, CulturedChloride ChannelsElectric StimulationElectrophysiologyFMRFamideGangliaImmunohistochemistryIon ChannelsMembrane PotentialsMembrane ProteinsNeuritesNeuronsNeuropeptidesNeurotransmitter AgentsPotassium ChannelsStereotyped BehaviorTetradecanoylphorbol AcetateConceptsBag cell neuronsCell neuronsAction potentialsElectrical stimulationVoltage-activated calcium currentsOnset of afterdischargePowerful inhibitory influenceIntact abdominal gangliaIon substitution experimentsVoltage-clamp experimentsAfferent nervesProtein kinase C. 5Channel blockersCalcium currentPrimary cell culturesAbdominal ganglionInhibitory influenceAfterdischargesCyclic AMP analogueFMRFaOutward currentsNeuronal processesNeuronsAplysia bag cell neuronsReversal potential
1985
Inhibitors of calcium-dependent enzymes prevent the onset of afterdischarge in the peptidergic bag cell neurons of Aplysia
DeRiemer S, Schweitzer B, Kaczmarek L. Inhibitors of calcium-dependent enzymes prevent the onset of afterdischarge in the peptidergic bag cell neurons of Aplysia. Brain Research 1985, 340: 175-180. PMID: 4027644, DOI: 10.1016/0006-8993(85)90790-5.Peer-Reviewed Original ResearchConceptsBag cell neuronsCalcium-dependent enzymesCell neuronsNeuroactive peptidesAttenuation of secretionOnset of afterdischargeBrief electrical stimulationPeptidergic bag cell neuronsAbility of stimulationEffect of TFPEffects of agentsNeuronal excitabilitySynaptic transmissionAfterdischargesNeurosecretory neuronsElectrical stimulationEndogenous burstingNeuronsSecretionCalmodulin-dependent enzymesProtein kinaseAplysiaStimulationOnsetAgents
1981
Serotonergic inhibition of afterdischarge in peptidergic bag cells
Jennings K, Host J, Kaczmarek L, Strumwasser F. Serotonergic inhibition of afterdischarge in peptidergic bag cells. Developmental Neurobiology 1981, 12: 579-590. PMID: 7310396, DOI: 10.1002/neu.480120606.Peer-Reviewed Original ResearchConceptsEgg-laying hormoneAfterdischarge activityConnective nervesBag cellsSpike frequencyPotassium channel blocker tetraethylammoniumEffects of serotoninBag cell afterdischargeChannel blocker tetraethylammoniumDose-dependent mannerResult of serotoninPeptide hormone releaseNeuroendocrine bag cellsSerotonergic inhibitionSerotonin inhibitionSerotonergic synapsesSerotonergic inputBag cell neuronsHormone releaseIntracellular recordingsSerotonin receptorsBlocker tetraethylammoniumD-butaclamolAfterdischargesElectrical stimulation