2015
Membrane Ion Channels and Ion Currents
Levitan I, Kaczmarek L. Membrane Ion Channels and Ion Currents. 2015, 63-84. DOI: 10.1093/med/9780199773893.003.0004.ChaptersSingle ion channelsIon currentMovement of ionsIon channelsParticular ionPlasma membraneSpecialized membrane proteinsMembrane ion channelsIonsAction potential firingNeuronal plasma membranePatch-clamp techniqueMembrane proteinsNeurons resultsCurrentClamp techniqueAction potentialsDetailed characterizationElectrical activityMembrane currentsMembrane voltageChannelsMacroscopic membrane currentsEssential propertiesComplex patternsDiversity in the Structure and Function of Ion Channels
Levitan I, Kaczmarek L. Diversity in the Structure and Function of Ion Channels. 2015, 127-150. DOI: 10.1093/med/9780199773893.003.0007.ChaptersIon channelsPotassium channelsFormation of heterotetramersAlternative splicingIndividual genesMultiple genesAuxiliary subunitsTwo-poreDiverse familyHuman diseasesMolecular biologyMessenger RNASubunitsDiversityGenesRectifier channelsVoltage-dependent sodiumChannel propertiesPatch-clamp techniqueSplicingDifferent mechanismsHeterotetramerClamp techniqueElectrophysiological measurementsRNA
1990
Control of potassium currents and cyclic AMP levels by autoactive neuropeptides in Aplysia neurons
Loechner K, Kaczmarek L. Control of potassium currents and cyclic AMP levels by autoactive neuropeptides in Aplysia neurons. Brain Research 1990, 532: 1-6. PMID: 2178030, DOI: 10.1016/0006-8993(90)91733-w.Peer-Reviewed Original ResearchConceptsVoltage-dependent potassium currentsCyclic AMP levelsBag cell neuronsPotassium currentCell neuronsAMP levelsAlpha-BCPWhole-cell patch-clamp techniqueCell patch-clamp techniqueBag cell afterdischargeTransient voltage-dependent potassium currentPatch-clamp techniqueDelayed potassium currentPharmacologic elevationClamp techniqueOutward currentsAfterdischargesNeuronsCell peptidesAplysia neuronsNeuropeptidesBeta-BCPConsistent effectSecond messengerAlpha
1986
Multiple components of delayed potassium current in peptidergic neurons of Aplysia: modulation by an activator of adenylate cyclase
Strong J, Kaczmarek L. Multiple components of delayed potassium current in peptidergic neurons of Aplysia: modulation by an activator of adenylate cyclase. Journal Of Neuroscience 1986, 6: 814-822. PMID: 2420948, PMCID: PMC6568473, DOI: 10.1523/jneurosci.06-03-00814.1986.Peer-Reviewed Original ResearchConceptsAction potentialsApplication of forskolinBag cell neuronsPotassium currentCell neuronsOutward currentsWhole-cell patch-clamp techniqueBag cell afterdischargePatch-clamp techniqueEffect of forskolinElevation of cAMPPeptidergic neuronsCalcium entryClamp techniqueAfterdischargesReproductive tractMsec depolarizationsAdenylate cyclasePrimary culturesHigh intracellular concentrationsNeuronsMin periodRepetitive activitySpike widthForskolin