Local urokinase delivery with the Channel balloon: Device safety, pharmacokinetics of intracoronary drug delivery, and efficacy of thrombolysis
Mitchel J, Barry J, Bow L, Alberghini T, Abbas S, McKay R. Local urokinase delivery with the Channel balloon: Device safety, pharmacokinetics of intracoronary drug delivery, and efficacy of thrombolysis. Catheterization And Cardiovascular Interventions 1997, 41: 254-260. PMID: 9213023, DOI: 10.1002/(sici)1097-0304(199707)41:3<254::aid-ccd5>3.0.co;2-5.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryAnimalsCell DivisionDrug Delivery SystemsEquipment DesignEquipment SafetyFeasibility StudiesFemaleFibrinolytic AgentsIliac ArteryMaleMuscle, Smooth, VascularProliferating Cell Nuclear AntigenSwineThrombolytic TherapyTreatment OutcomeTunica MediaUrokinase-Type Plasminogen ActivatorConceptsLocal urokinase deliveryConventional balloon angioplastyBalloon angioplastyDrug infusionDrug depositionPorcine modelLocal drug delivery catheterLocal deliveryDrug delivery catheterEfficacy of thrombolysisComparative histologic studyCatheter infusionBalloon useVessel traumaCoronary arteryLocal infusionThrombolytic techniquesIntracoronary useHistologic changesBalloon inflationIntramural depositionHistologic studyArtery ratioCoronary vesselsAnesthetized swineLocalized delivery of heparin to angioplasty sites with iontophoresis
Mitchel J, Azrin M, Fram D, Bow L, McKay R. Localized delivery of heparin to angioplasty sites with iontophoresis. Catheterization And Cardiovascular Interventions 1997, 41: 315-323. PMID: 9213031, DOI: 10.1002/(sici)1097-0304(199707)41:3<315::aid-ccd13>3.0.co;2-m.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, BalloonAngioplasty, Balloon, CoronaryAnimalsAnticoagulantsAortaCoronary VesselsDose-Response Relationship, DrugDrug Delivery SystemsElastic TissueEquipment DesignHeparinIontophoresisMaleMuscle, Smooth, VascularPlatelet AggregationRatsRats, Sprague-DawleySwineTunica IntimaTunica MediaConceptsPorcine coronary arteriesBalloon injuryPlatelet depositionDrug depositionCoronary arteryIontophoretic catheterHeparin deliveryControl vesselsLocal deliveryContralateral control vesselsIontophoresis of salineEarly platelet depositionFluorescent heparinBalloon inflation pressureInternal elastic laminaIntramural localizationAngioplasty siteBalloon angioplastyCoronary studiesHemodynamic sequelaeIliac vesselsIntramural depositionImmediate drug deliveryPlatelet studiesArtery