1997
Local delivery of c‐myb antisense oligonucleotides during balloon angioplasty
Azrin M, Mitchel J, Bow L, Pedersen C, Cartun R, Aretz T, Waters D, McKay R. Local delivery of c‐myb antisense oligonucleotides during balloon angioplasty. Catheterization And Cardiovascular Interventions 1997, 41: 232-240. PMID: 9213020, DOI: 10.1002/(sici)1097-0304(199707)41:3<232::aid-ccd2>3.0.co;2-7.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryAnimalsAutoradiographyCell DivisionCoronary DiseaseCoronary VesselsDrug Delivery SystemsFeasibility StudiesFemaleLymphocyte ActivationMiceMicroscopy, FluorescenceMuscle, Smooth, VascularOligonucleotides, AntisenseProliferating Cell Nuclear AntigenProto-Oncogene ProteinsProto-Oncogene Proteins c-mybSwineTrans-ActivatorsConceptsSmooth muscle cell proliferationMuscle cell proliferationIntraluminal deliveryBalloon angioplastyCell proliferationLess cellular proliferationQuantitative immunohistochemical stainingCatheter-based systemC-MybC-myb antisenseCell nuclear antigenArterial injuryPeripheral arteriesLymphocyte proliferationContralateral vesselCarotid arteryImmunohistochemical stainingAngioplastyArterial mediaArterial segmentsNuclear antigenLocal deliveryCellular proliferationArteryProliferation
1996
Functional and structural alterations with 24-hour myocardial hibernation and recovery after reperfusion. A pig model of myocardial hibernation.
Chen C, Chen L, Fallon J, Ma L, Li L, Bow L, Knibbs D, McKay R, Gillam L, Waters D. Functional and structural alterations with 24-hour myocardial hibernation and recovery after reperfusion. A pig model of myocardial hibernation. Circulation 1996, 94: 507-16. PMID: 8759096, DOI: 10.1161/01.cir.94.3.507.Peer-Reviewed Original ResearchConceptsRegional coronary flowMyocardial hibernationCoronary flowRegional wall thickeningWall thickeningPig modelShort-term myocardial hibernationRegional lactate productionRate-pressure productCoronary artery stenosisCoronary flow reductionAcute myocardial ischemiaUltrastructural changesLactate productionLocal metabolic changesModerate flow reductionShort-term hibernationRegional oxygen consumptionFlow reductionMyocardium undergoesLAD stenosisArtery stenosisLAD flowMyocardial infarctionStructural alterations