2000
Modulation of efficacies and pharmacokinetics of antibiotics by granulocyte colony-stimulating factor in neutropenic mice with multidrug-resistant Enterococcus faecalis infection
Onyeji C, Nicolau D, Nightingale C, Bow L. Modulation of efficacies and pharmacokinetics of antibiotics by granulocyte colony-stimulating factor in neutropenic mice with multidrug-resistant Enterococcus faecalis infection. Journal Of Antimicrobial Chemotherapy 2000, 46: 429-436. PMID: 10980170, DOI: 10.1093/jac/46.3.429.Peer-Reviewed Original ResearchConceptsGranulocyte colony-stimulating factorG-CSFColony-stimulating factorInfected animalsNeutropenic miceFaecalis infectionDisposition of vancomycinNon-neutropenic animalsEnterococcus faecalis infectionPharmacokinetics of antibioticsInduction of neutropeniaConcentration-time curveEfficacy of gentamicinDose-dependent increaseE. faecalis infectionNeutropenic patientsPharmacokinetic interactionsDosing regimensSame infectionPlasma clearanceUseful adjunctGentamicinInfectionVancomycinMice
1999
Influence of adjunctive interferon-γ on treatment of gentamicin- and vancomycin-resistant Enterococcus faecalis infection in mice
Onyeji C, Bui K, Nicolau D, Nightingale C, Bow L, Quintiliani R. Influence of adjunctive interferon-γ on treatment of gentamicin- and vancomycin-resistant Enterococcus faecalis infection in mice. International Journal Of Antimicrobial Agents 1999, 12: 301-309. PMID: 10493606, DOI: 10.1016/s0924-8579(99)00055-2.Peer-Reviewed Original ResearchConceptsIFN-gammaFaecalis infectionDisposition of gentamicinInfected neutropenic miceNon-neutropenic miceTreatment of gentamicinSerious enterococcal infectionsEnterococcus faecalis infectionNew treatment optionsE. faecalis infectionOutcome of therapyActivity of gentamicinE. faecalis clinical isolatesDose-dependent mannerPharmacokinetic interactionsConcurrent administrationDosing regimensNeutropenic miceCombination therapyInfectious burdenTreatment optionsEnterococcal infectionsIntraperitoneal inoculationClinical isolatesInfected animals
1997
Local delivery of c‐myb antisense oligonucleotides during balloon angioplasty
Azrin M, Mitchel J, Bow L, Pedersen C, Cartun R, Aretz T, Waters D, McKay R. Local delivery of c‐myb antisense oligonucleotides during balloon angioplasty. Catheterization And Cardiovascular Interventions 1997, 41: 232-240. PMID: 9213020, DOI: 10.1002/(sici)1097-0304(199707)41:3<232::aid-ccd2>3.0.co;2-7.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryAnimalsAutoradiographyCell DivisionCoronary DiseaseCoronary VesselsDrug Delivery SystemsFeasibility StudiesFemaleLymphocyte ActivationMiceMicroscopy, FluorescenceMuscle, Smooth, VascularOligonucleotides, AntisenseProliferating Cell Nuclear AntigenProto-Oncogene ProteinsProto-Oncogene Proteins c-mybSwineTrans-ActivatorsConceptsSmooth muscle cell proliferationMuscle cell proliferationIntraluminal deliveryBalloon angioplastyCell proliferationLess cellular proliferationQuantitative immunohistochemical stainingCatheter-based systemC-MybC-myb antisenseCell nuclear antigenArterial injuryPeripheral arteriesLymphocyte proliferationContralateral vesselCarotid arteryImmunohistochemical stainingAngioplastyArterial mediaArterial segmentsNuclear antigenLocal deliveryCellular proliferationArteryProliferation
1985
Neonatal tolerance increases efficacy of antisera production
Sharpe R, Schweizer R, Bow L. Neonatal tolerance increases efficacy of antisera production. Medical Hypotheses 1985, 17: 265-270. PMID: 3876502, DOI: 10.1016/0306-9877(85)90132-x.Peer-Reviewed Original Research