2000
Modulation of efficacies and pharmacokinetics of antibiotics by granulocyte colony-stimulating factor in neutropenic mice with multidrug-resistant Enterococcus faecalis infection
Onyeji C, Nicolau D, Nightingale C, Bow L. Modulation of efficacies and pharmacokinetics of antibiotics by granulocyte colony-stimulating factor in neutropenic mice with multidrug-resistant Enterococcus faecalis infection. Journal Of Antimicrobial Chemotherapy 2000, 46: 429-436. PMID: 10980170, DOI: 10.1093/jac/46.3.429.Peer-Reviewed Original ResearchConceptsGranulocyte colony-stimulating factorG-CSFColony-stimulating factorInfected animalsNeutropenic miceFaecalis infectionDisposition of vancomycinNon-neutropenic animalsEnterococcus faecalis infectionPharmacokinetics of antibioticsInduction of neutropeniaConcentration-time curveEfficacy of gentamicinDose-dependent increaseE. faecalis infectionNeutropenic patientsPharmacokinetic interactionsDosing regimensSame infectionPlasma clearanceUseful adjunctGentamicinInfectionVancomycinMice
1999
Influence of adjunctive interferon-γ on treatment of gentamicin- and vancomycin-resistant Enterococcus faecalis infection in mice
Onyeji C, Bui K, Nicolau D, Nightingale C, Bow L, Quintiliani R. Influence of adjunctive interferon-γ on treatment of gentamicin- and vancomycin-resistant Enterococcus faecalis infection in mice. International Journal Of Antimicrobial Agents 1999, 12: 301-309. PMID: 10493606, DOI: 10.1016/s0924-8579(99)00055-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalDrug Resistance, MicrobialDrug Therapy, CombinationEnterococcus faecalisFemaleGentamicinsGram-Positive Bacterial InfectionsInterferon-gammaMiceVancomycinConceptsIFN-gammaFaecalis infectionDisposition of gentamicinInfected neutropenic miceNon-neutropenic miceTreatment of gentamicinSerious enterococcal infectionsEnterococcus faecalis infectionNew treatment optionsE. faecalis infectionOutcome of therapyActivity of gentamicinE. faecalis clinical isolatesDose-dependent mannerPharmacokinetic interactionsConcurrent administrationDosing regimensNeutropenic miceCombination therapyInfectious burdenTreatment optionsEnterococcal infectionsIntraperitoneal inoculationClinical isolatesInfected animalsInterferon-γ effects on activities of gentamicin and vancomycin against Enterococcus faecalis resistant to the drugs: an in vitro study with human neutrophils
Onyeji C, Nicolau D, Nightingale C, Bow L. Interferon-γ effects on activities of gentamicin and vancomycin against Enterococcus faecalis resistant to the drugs: an in vitro study with human neutrophils. International Journal Of Antimicrobial Agents 1999, 11: 31-37. PMID: 10075275, DOI: 10.1016/s0924-8579(98)00085-5.Peer-Reviewed Original ResearchMeSH KeywordsCombined Modality TherapyDrug Resistance, MicrobialDrug Resistance, MultipleEnterococcus faecalisGentamicinsGram-Positive Bacterial InfectionsHumansImmunotherapyIn Vitro TechniquesInterferon-gammaNeutrophilsVancomycinConceptsIFN-gammaHuman neutrophilsMajor therapeutic challengeMultidrug-resistant E. faecalisAnti-enterococcal activityEffective antimicrobial therapyMultidrug-resistant enterococciActivity of gentamicinPotential underlying mechanismsEnterococcus faecalisTherapeutic troughMaximal growth inhibitionTherapeutic challengeSerum troughReactive oxygen intermediatesAntimicrobial therapyUseful adjunctClinical isolatesActivated secretionNeutrophilsPeak levelsGentamicinVancomycinPeak concentrationE. faecalis