2024
Sex Modifies the Severity and Outcome of Spontaneous Intracerebral Hemorrhage
Rivier C, Renedo D, Marini S, Magid‐Bernstein J, de Havenon A, Rosand J, Hanley D, Ziai W, Mayer S, Woo D, Sansing L, Sheth K, Anderson C, Falcone G. Sex Modifies the Severity and Outcome of Spontaneous Intracerebral Hemorrhage. Annals Of Neurology 2024 PMID: 39499118, DOI: 10.1002/ana.27123.Peer-Reviewed Original ResearchRisk of hematoma expansionHighest risk of hematoma expansionRisk of poor outcomesIntracerebral hemorrhageHematoma expansionHigh riskMale sexPoor outcomeOutcome of spontaneous intracerebral hemorrhageClinical characteristics of patientsStudies of intracerebral hemorrhageNon-traumatic intracerebral hemorrhageIndividual patient data meta-analysisPatient data meta-analysisSpontaneous intracerebral hemorrhageSingle-center studyIntracerebral hemorrhage patientsHigh risk of expansionCharacteristics of patientsIntracerebral hemorrhage severityPoor functional outcomeRandomized clinical trialsData meta-analysisHemorrhage volumeClinical characteristicsAutomated detection of early signs of irreversible ischemic change on CTA source images in patients with large vessel occlusion
Mak A, Matouk C, Avery E, Behland J, Haider S, Frey D, Madai V, Vajkoczy P, Griessenauer C, Zand R, Hendrix P, Abedi V, Sanelli P, Falcone G, Petersen N, Sansing L, Sheth K, Payabvash S, Malhotra A. Automated detection of early signs of irreversible ischemic change on CTA source images in patients with large vessel occlusion. PLOS ONE 2024, 19: e0304962. PMID: 38870240, PMCID: PMC11175522, DOI: 10.1371/journal.pone.0304962.Peer-Reviewed Original ResearchConceptsDiffusion-weighted imagingLarge vessel occlusionIrreversible ischemic changesPoor functional outcomeFunctional outcomesIschemic changesInfarct volumeAlberta Stroke Program Early CT ScorePredicting poor functional outcomeVessel occlusionFollow-up diffusion-weighted imagingAnterior circulation LVO strokeCTA source imagesReceiver operating characteristic curveExpert human readersPredicting final infarctionASPECTS regionsAdmission CTANon-inferior performanceBaseline CTACT scoreFinal infarctEndovascular therapyHU attenuationValidation cohort
2020
Blood Pressure Decreases Occur Throughout Endovascular Thrombectomy and Are Associated with Poor Functional Outcome (4872)
Kimmel A, Silverman A, Kodali S, Strander S, Nguyen C, Peshwe K, Wang A, Cardenas G, Holcombe A, Zevallos C, Dandapat S, Sansing L, Schindler J, Falcone G, Matouk C, Sheth K, Ortega-Gutierrez S, Petersen N. Blood Pressure Decreases Occur Throughout Endovascular Thrombectomy and Are Associated with Poor Functional Outcome (4872). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.4872.Peer-Reviewed Original ResearchFixed Compared With Autoregulation-Oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke
Petersen NH, Silverman A, Strander SM, Kodali S, Wang A, Sansing LH, Schindler JL, Falcone GJ, Gilmore EJ, Jasne AS, Cord B, Hebert RM, Johnson M, Matouk CC, Sheth KN. Fixed Compared With Autoregulation-Oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke. Stroke 2020, 51: 914-921. PMID: 32078493, PMCID: PMC7050651, DOI: 10.1161/strokeaha.119.026596.Peer-Reviewed Original ResearchConceptsSystolic BP thresholdMean arterial pressureArterial pressureEndovascular thrombectomyIschemic strokeSystolic BPFunctional outcomePercent timeFurther brain injuryModified Rankin ScaleBlood pressure changesPoor functional outcomeBP thresholdAutoregulatory indexHemorrhagic transformationMechanical thrombectomyRankin ScaleBlood pressureBP targetsHemodynamic managementAcute phaseBP managementStroke patientsCerebral autoregulationWorse outcomes
2019
Transforming growth factor-β promotes basement membrane fibrosis, alters perivascular cerebrospinal fluid distribution, and worsens neurological recovery in the aged brain after stroke
Howe MD, Furr JW, Munshi Y, Roy-O’Reilly M, Maniskas ME, Koellhoffer EC, d’Aigle J, Sansing LH, McCullough LD, Urayama A. Transforming growth factor-β promotes basement membrane fibrosis, alters perivascular cerebrospinal fluid distribution, and worsens neurological recovery in the aged brain after stroke. GeroScience 2019, 41: 543-559. PMID: 31721012, PMCID: PMC6885082, DOI: 10.1007/s11357-019-00118-7.Peer-Reviewed Original ResearchConceptsPoor functional recoveryFunctional recoveryExperimental strokeAstrocyte activationStroke patientsAged brainCultured astrocytesSerum TGF-β levelsTGF-β receptor inhibitionPotential new treatment strategyGlial scar developmentElderly stroke patientsTGF-β levelsPoor functional outcomeOxygen-glucose deprivationCerebrospinal fluid distributionNew treatment strategiesPrimary cultured astrocytesExogenous TGF-β stimulationBasement membraneTGF-β stimulationNeurological recoveryElderly patientsSerum levelsFunctional outcomeAntiplatelet Therapy After Spontaneous Intracerebral Hemorrhage and Functional Outcomes
Murthy SB, Biffi A, Falcone GJ, Sansing LH, Torres Lopez V, Navi BB, Roh DJ, Mandava P, Hanley DF, Ziai WC, Kamel H, Rosand J, Sheth KN, Butcher K, Davis S, Gregson B, Lees K, Lyden P, Mayer S, Muir K, Steiner T. Antiplatelet Therapy After Spontaneous Intracerebral Hemorrhage and Functional Outcomes. Stroke 2019, 50: 3057-3063. PMID: 31895618, PMCID: PMC6941441, DOI: 10.1161/strokeaha.119.025972.Peer-Reviewed Original ResearchConceptsAntiplatelet therapyIntracerebral hemorrhageFunctional outcomeHematoma locationCause mortalityMajor disabilityVirtual International Stroke Trials Archive databaseCox proportional regression analysisConclusions Antiplatelet therapyRecurrent intracerebral hemorrhageProportional regression analysisPoor functional outcomeRandomized clinical trialsSpontaneous intracerebral hemorrhagePaucity of dataAntiplatelet medicationsStroke RegistryThromboembolic riskHazard ratioMulticenter cohortPrimary outcomeMedian timeICH patientsClinical trialsMeta-analyzed dataPatients with Parenchymal Hemorrhagic Transformation and Poor Functional Outcome Have Distinct Systolic Blood Pressure Trajectories 72 hours After Mechanical Thrombectomy (P5.3-007)
Kodali S, Strander S, Silverman A, Agarwal T, Stretz C, Wang A, Sansing L, Schindler J, Sheth K, Petersen N. Patients with Parenchymal Hemorrhagic Transformation and Poor Functional Outcome Have Distinct Systolic Blood Pressure Trajectories 72 hours After Mechanical Thrombectomy (P5.3-007). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.p5.3-007.Peer-Reviewed Original ResearchPoor functional outcomeHemorrhagic transformationMechanical thrombectomyFunctional outcomeThrombectomyPatients