Featured Publications
Mineralocorticoid and Estrogen Receptors in Endothelial Cells Coordinately Regulate Microvascular Function in Obese Female Mice
Biwer L, Carvajal B, Lu Q, Man J, Jaffe I. Mineralocorticoid and Estrogen Receptors in Endothelial Cells Coordinately Regulate Microvascular Function in Obese Female Mice. Hypertension 2021, 77: 2117-2126. PMID: 33934622, PMCID: PMC8119365, DOI: 10.1161/hypertensionaha.120.16911.Peer-Reviewed Original Research
2018
Vascular Mineralocorticoid Receptor: Evolutionary Mediator of Wound Healing Turned Harmful by Our Modern Lifestyle
Biwer L, Wallingford M, Jaffe I. Vascular Mineralocorticoid Receptor: Evolutionary Mediator of Wound Healing Turned Harmful by Our Modern Lifestyle. American Journal Of Hypertension 2018, 32: 123-134. PMID: 30380007, PMCID: PMC6331708, DOI: 10.1093/ajh/hpy158.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCardiovascular DiseasesDiet, High-FatEndothelial CellsEndothelium, VascularEvolution, MolecularHemodynamicsHumansLife StyleMuscle, Smooth, VascularMyocytes, Smooth MuscleReceptors, MineralocorticoidRisk FactorsSedentary BehaviorSignal TransductionSodium, DietaryVascular RemodelingWound HealingConceptsVascular mineralocorticoid receptorMineralocorticoid receptorActivation of MRDiffuse vascular damageMechanical vascular injuryHigh sodium dietBlood pressure maintenanceVascular tone regulationSmooth muscle cellsSodium dietBlood pressureMR activationVascular damagePhysical inactivityVascular injuryAdvanced ageTone regulationCardiovascular diseaseVascular remodelingSurvival advantageElectrolyte homeostasisVascular wallMuscle cellsModern lifestyleMR functionEndothelial cell α-globin and its molecular chaperone α-hemoglobin–stabilizing protein regulate arteriolar contractility
Lechauve C, Butcher J, Freiwan A, Biwer L, Keith J, Good M, Ackerman H, Tillman H, Kiger L, Isakson B, Weiss M. Endothelial cell α-globin and its molecular chaperone α-hemoglobin–stabilizing protein regulate arteriolar contractility. Journal Of Clinical Investigation 2018, 128: 5073-5082. PMID: 30295646, PMCID: PMC6205378, DOI: 10.1172/jci99933.Peer-Reviewed Original Research
2016
Endoplasmic reticulum‐mediated signalling in cellular microdomains
Biwer L, Isakson B. Endoplasmic reticulum‐mediated signalling in cellular microdomains. Acta Physiologica 2016, 219: 162-175. PMID: 26973141, PMCID: PMC5018912, DOI: 10.1111/apha.12675.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCalcium ChannelsCytoskeletonEndoplasmic ReticulumHomeostasisMembrane MicrodomainsSignal TransductionConceptsEndoplasmic reticulumER-mitochondria junctionsImportant cellular organellesSpecific membrane proteinsSynthesis of proteinsLocalized proteinsER membraneCellular physiologyLipid signalingCellular signalingER architectureMembrane proteinsPhospholipid synthasesCellular stressCellular organellesCellular microdomainsOrganism homeostasisCytoplasmic networkSignalingPhospholipid transferIon channelsLipid synthesisTransfer proteinProteinElement expression