2016
Lipid composition of the myoendothelial junction allows for compartmentalized eNOS function
Biwer L, Taddeo E, Hoehn K, Straub A, Isakson B. Lipid composition of the myoendothelial junction allows for compartmentalized eNOS function. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.727.9.Peer-Reviewed Original ResearchEndothelial nitric oxide synthaseSmooth muscle cellsEndothelial cellsMyoendothelial junctionsResistance arteriesEC endothelial nitric oxide synthaseNeighboring smooth muscle cellsTumor necrosis factor alphaBlood pressure regulationNecrosis factor alphaNitric oxide synthasePKC activityHuman smooth muscle cellsInternal elastic laminaER calcium releaseTHP-1 monocytesCo-cultured endothelial cellsVascular toneENOS functionOxide synthaseFactor alphaGap junction inhibitionLipid compositionDifferential lipid compositionPhenylephrine
2015
Endothelial nitric oxide synthase in the microcirculation
Shu X, Keller T, Begandt D, Butcher J, Biwer L, Keller A, Columbus L, Isakson B. Endothelial nitric oxide synthase in the microcirculation. Cellular And Molecular Life Sciences 2015, 72: 4561-4575. PMID: 26390975, PMCID: PMC4628887, DOI: 10.1007/s00018-015-2021-0.Peer-Reviewed Original ResearchConceptsEndothelial nitric oxide synthaseNitric oxide synthaseOxide synthaseAnti-inflammatory mediatorsRegulation of eNOSRed blood cellsMicrovascular effectsVessel toneImmune responsePharmacological agentsENOS enzymeNitric oxideBlood cellsNO actionKey moleculesENOSVariety of effectsPhysiological roleCellsVasodilatorsSynthaseMicrocirculation