Featured Publications
Non–Endoplasmic Reticulum–Based Calr (Calreticulin) Can Coordinate Heterocellular Calcium Signaling and Vascular Function
Biwer L, Good M, Hong K, Patel R, Agrawal N, Looft-Wilson R, Sonkusare S, Isakson B. Non–Endoplasmic Reticulum–Based Calr (Calreticulin) Can Coordinate Heterocellular Calcium Signaling and Vascular Function. Arteriosclerosis Thrombosis And Vascular Biology 2017, 38: 120-130. PMID: 29122814, PMCID: PMC5746467, DOI: 10.1161/atvbaha.117.309886.Peer-Reviewed Original ResearchConceptsThird-order mesenteric arteriesBlood pressureMesenteric arteryVascular functionCalcium signalingIEL holesApplication of CChMyoendothelial junctionsCalcium eventsER calciumSmooth muscle cellsInternal elastic laminaVascular reactivityResistance arteriesSmall arteriesSame arteryKnockout miceArteryΔ miceElastic laminaMuscle cellsEndoplasmic reticulum calciumMiceCALRCalcium signals
2017
Calreticulin localized to the myoendothelial junction mediates heterocellular communication in resistance arteries
Biwer L, Good M, Hong K, Patel R, Agrawal N, Looft‐Wilson R, Sonkusare S, Isakson B. Calreticulin localized to the myoendothelial junction mediates heterocellular communication in resistance arteries. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.681.12.Peer-Reviewed Original ResearchEndoplasmic reticulumHeterocellular communicationSmooth muscle cellsER retention signal KDELMyoendothelial junctionsExpression of ERCa 2Proteomic screenConditional knockout micePresence of calreticulinSecond messengerCell extensionsER-TrackerBidirectional signalingBinding proteinCalcium binding proteinSignificant enrichmentCalreticulinER calciumAgonist stimulationCytoplasmic contactMuscle cellsProteinKnockout miceSmooth muscle agonists