2024
Association between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60–69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study
Sun P, Guo X, Ding E, Li C, Ren H, Xu Y, Qian J, Deng F, Shi W, Dong H, Lin E, Guo P, Fang J, Zhang Q, Zhao W, Tong S, Lu X, Pollitt K, Shi X, Tang S. Association between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60–69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study. Environmental Health Perspectives 2024, 132: 077005. PMID: 39028628, PMCID: PMC11259245, DOI: 10.1289/ehp13865.Peer-Reviewed Original ResearchConceptsFat mass indicatorsHealthy older adultsBayesian kernel machine regressionVisceral fat areaOlder adultsPercent body fatBody compositionBody fat massExposome-wide association studyPrevention of chronic diseasesAir pollution exposureBody composition indicatorsMediation analysisInBody 770 deviceHealthy adultsAssociated with increased body fat massBody composition changesKernel machine regressionBayesian kernel machine regression modelsChronic diseasesPollution exposureBody fatAssociation studiesAdverse health effectsFat area
2023
Assessment of children's personal and land use regression model-estimated exposure to NO2 in Springfield, Massachusetts
Gao D, Esenther S, Minet L, De Jesus A, Hudson S, Leaderer B, Hatzopoulou M, Godri Pollitt K. Assessment of children's personal and land use regression model-estimated exposure to NO2 in Springfield, Massachusetts. The Science Of The Total Environment 2023, 892: 164681. PMID: 37302586, DOI: 10.1016/j.scitotenv.2023.164681.Peer-Reviewed Original ResearchAdequacy of stationary measurements as proxies for residential personal exposure to gaseous and particle air pollutants
González Serrano V, Lin E, Godri Pollitt K, Licina D. Adequacy of stationary measurements as proxies for residential personal exposure to gaseous and particle air pollutants. Environmental Research 2023, 231: 116197. PMID: 37224948, DOI: 10.1016/j.envres.2023.116197.Peer-Reviewed Original ResearchConceptsVolatile organic compoundsOrganic compoundsTotal volatile organic compoundsPassive samplersSingle COCompoundsCOPollutantsCarbon dioxideStationary samplesEnvironmental monitorsReal-time sensorsSVOCsParticlesHigh concentrationsPersonal exposure monitorsAirborne pollutantsInhalation exposure assessmentAir quality monitoringDioxideAir pollutantsParticle number concentrationConcentrationSamplerParticle pollutantsWearable Passive Samplers for Assessing Environmental Exposure to Organic Chemicals: Current Approaches and Future Directions
Okeme J, Koelmel J, Johnson E, Lin E, Gao D, Pollitt K. Wearable Passive Samplers for Assessing Environmental Exposure to Organic Chemicals: Current Approaches and Future Directions. Current Environmental Health Reports 2023, 10: 84-98. PMID: 36821032, DOI: 10.1007/s40572-023-00392-w.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutantsComplex MixturesEnvironmental ExposureEnvironmental MonitoringHumansVolatile Organic CompoundsConceptsPassive samplersOrganic chemicalsExposure assessmentHigh-throughput chemical analysisSemi-volatile organic chemicalsComplex mixturesChemical analysisEnvironmental health researchEnvironmental contaminantsPopulation scaleMonitoring approachActive air samplingQuantitative exposure assessmentEvaluation of exposureCompositional diversityAnalytical challengesHundreds of chemicalsPersonal exposurePopulation levelExposure estimatesSamplerActive samplersEnvironmental chemicalsContaminantsDynamic mixture
2022
Air Pollution and Pediatric Respiratory Hospitalizations: Effect Modification by Particle Constituents and Oxidative Potential.
Korsiak J, Lavigne E, You H, Pollitt K, Kulka R, Hatzopoulou M, Evans G, Burnett RT, Weichenthal S. Air Pollution and Pediatric Respiratory Hospitalizations: Effect Modification by Particle Constituents and Oxidative Potential. American Journal Of Respiratory And Critical Care Medicine 2022, 206: 1370-1378. PMID: 35802828, DOI: 10.1164/rccm.202205-0896oc.Peer-Reviewed Original ResearchConceptsRespiratory hospitalizationsConditional logistic regression modelsPediatric respiratory hospitalizationsFine particulate air pollutionCase-crossover studyLogistic regression modelsParticulate air pollutionOxidant gasesRespiratory healthEffect modificationOdds ratioHospitalizationParticle oxidative potentialStrong associationConfidence intervalsOxidative potentialMedianPositive associationChildrenAssociationMedian valueRegression modelsFine particulate matterOutdoor fine particlesAir pollutionUnequal airborne exposure to toxic metals associated with race, ethnicity, and segregation in the USA
Kodros J, Bell M, Dominici F, L’Orange C, Godri Pollitt K, Weichenthal S, Wu X, Volckens J. Unequal airborne exposure to toxic metals associated with race, ethnicity, and segregation in the USA. Nature Communications 2022, 13: 6329. PMID: 36319637, PMCID: PMC9626599, DOI: 10.1038/s41467-022-33372-z.Peer-Reviewed Original ResearchLong-term Exposure to Oxidant Gases and Mortality: Effect Modification by PM2.5 Transition Metals and Oxidative Potential
Toyib O, Lavigne E, Traub A, Umbrio D, You H, Ripley S, Pollitt K, Shin T, Kulka R, Jessiman B, Tjepkema M, Martin R, Stieb DM, Hatzopoulou M, Evans G, Burnett RT, Weichenthal S. Long-term Exposure to Oxidant Gases and Mortality: Effect Modification by PM2.5 Transition Metals and Oxidative Potential. Epidemiology 2022, 33: 767-776. PMID: 36165987, PMCID: PMC9531968, DOI: 10.1097/ede.0000000000001538.Peer-Reviewed Original ResearchConceptsLong-term exposureOxidative stressFine particulate air pollutionProportional hazards modelAir pollution health effectsHealth impactsObserved health impactsParticulate air pollutionCohort studyMortality outcomesOxidant gasesEffect modificationInterquartile increaseHazards modelAdverse health impactsNonaccidental mortalityGSH levelsHealth effectsMortalityLand use regression modelsOxidative potentialMedianRegression modelsExposurePM 2.5Personal air pollutant exposure monitoring in South African children in the VHEMBE birth cohort
DeLay K, Lin EZ, Koelmel JP, Bornman R, Obida M, Chevrier J, Godri Pollitt KJ. Personal air pollutant exposure monitoring in South African children in the VHEMBE birth cohort. Environment International 2022, 170: 107524. PMID: 36260950, PMCID: PMC9982749, DOI: 10.1016/j.envint.2022.107524.Peer-Reviewed Original ResearchConceptsBirth cohortMalaria controlEnvironment (MACE) birth cohortVenda Health ExaminationEnvironmental exposuresBurden of diseaseIndoor residual sprayingSouth African childrenHousehold air pollutionMiddle-income countriesHealth examinationNon-invasive methodAfrican childrenPersonal exposure assessmentResidual sprayingExposure levelsPersonal exposureExposure assessmentExposure monitoringRural regionsChildrenHigh exposureEnvironmental contaminantsCohortExposure
2021
Predicting Spatial Variations in Multiple Measures of PM2.5 Oxidative Potential and Magnetite Nanoparticles in Toronto and Montreal, Canada
Ripley S, Minet L, Zalzal J, Godri Pollitt K, Gao D, Lakey PSJ, Shiraiwa M, Maher BA, Hatzopoulou M, Weichenthal S. Predicting Spatial Variations in Multiple Measures of PM2.5 Oxidative Potential and Magnetite Nanoparticles in Toronto and Montreal, Canada. Environmental Science And Technology 2021, 56: 7256-7265. PMID: 34965092, DOI: 10.1021/acs.est.1c05364.Peer-Reviewed Original ResearchAssociation of Sulfur, Transition Metals, and the Oxidative Potential of Outdoor PM2.5 with Acute Cardiovascular Events: A Case-Crossover Study of Canadian Adults
Weichenthal S, Lavigne E, Traub A, Umbrio D, You H, Pollitt K, Shin T, Kulka R, Stieb DM, Korsiak J, Jessiman B, Brook JR, Hatzopoulou M, Evans G, Burnett RT. Association of Sulfur, Transition Metals, and the Oxidative Potential of Outdoor PM2.5 with Acute Cardiovascular Events: A Case-Crossover Study of Canadian Adults. Environmental Health Perspectives 2021, 129: 107005. PMID: 34644144, PMCID: PMC8513754, DOI: 10.1289/ehp9449.Peer-Reviewed Original ResearchConceptsAcute cardiovascular eventsCardiovascular eventsCase-crossover studyOdds ratioConditional logistic regression modelsFine particulate air pollutionLogistic regression modelsParticulate air pollutionStrength of associationCanadian adultsPopulation health risksObserved associationsRecent evidenceWeak associationOxidative potentialHealth impactsMenAssociationHealth risksMedian valueRegression modelsInfluence associationsAssociated health impactsSimilar patternOutdoor PM2.5The exposome in practice: an exploratory panel study of biomarkers of air pollutant exposure in Chinese people aged 60–69 years (China BAPE Study)
Tang S, Li T, Fang J, Chen R, Cha Y, Wang Y, Zhu M, Zhang Y, Chen Y, Du Y, Yu T, Thompson DC, Godri Pollitt KJ, Vasiliou V, Ji JS, Kan H, Zhang JJ, Shi X. The exposome in practice: an exploratory panel study of biomarkers of air pollutant exposure in Chinese people aged 60–69 years (China BAPE Study). Environment International 2021, 157: 106866. PMID: 34525388, DOI: 10.1016/j.envint.2021.106866.Peer-Reviewed Original ResearchMeSH KeywordsAgedAir PollutantsBiomarkersChinaEnvironmental ExposureExposomeHumansProspective StudiesConceptsAir pollutant exposurePotential adverse clinical outcomesPollutant exposureExploratory panel studyAdverse clinical outcomesHealthy elderly subjectsAdverse health outcomesAirborne pollutant exposureAir pollution exposureAdverse health effectsClinical outcomesModifiable factorsElderly subjectsHealthy residentsNovel biomarkersEndogenous exposureExogenous exposureHealth outcomesPotential biomarkersAirborne exposurePollution exposureSuboptimal assessmentAdverse health impactsAssociated biomarkersComprehensive biomarkerPredicting Spatial Variations in Multiple Measures of Oxidative Burden for Outdoor Fine Particulate Air Pollution across Canada
Xu JW, Martin RV, Evans GJ, Umbrio D, Traub A, Meng J, van Donkelaar A, You H, Kulka R, Burnett RT, Pollitt K, Weichenthal S. Predicting Spatial Variations in Multiple Measures of Oxidative Burden for Outdoor Fine Particulate Air Pollution across Canada. Environmental Science And Technology 2021, 55: 9750-9760. PMID: 34241996, DOI: 10.1021/acs.est.1c01210.Peer-Reviewed Original ResearchExploring personal chemical exposures in China with wearable air pollutant monitors: A repeated-measure study in healthy older adults in Jinan, China
Guo P, Lin EZ, Koelmel JP, Ding E, Gao Y, Deng F, Dong H, Liu Y, Cha Y, Fang J, Shi X, Tang S, Godri Pollitt KJ. Exploring personal chemical exposures in China with wearable air pollutant monitors: A repeated-measure study in healthy older adults in Jinan, China. Environment International 2021, 156: 106709. PMID: 34153889, DOI: 10.1016/j.envint.2021.106709.Peer-Reviewed Original ResearchMeSH KeywordsAgedAir PollutantsChinaEnvironmental MonitoringGas Chromatography-Mass SpectrometryHumansWearable Electronic DevicesConceptsVolatile organic compoundsPolycyclic aromatic hydrocarbonsAirborne chemical contaminantsPersonal exposure profilesPassive air samplersOrganic compoundsPassive samplersChemical classesChemical contaminantsChemical analysisPersonal chemical exposureCertain polycyclic aromatic hydrocarbonsChemical exposureAirborne compoundsAirborne contaminantsCompoundsAromatic hydrocarbonsContaminantsAir monitoring sitesComprehensive characterizationPhthalateNitroaromaticsRepeated-measures studyAir samplerNitrobenzeneUse of Untargeted Metabolomics to Explore the Air Pollution-Related Disease Continuum
Jin L, Godri Pollitt KJ, Liew Z, Rosen Vollmar AK, Vasiliou V, Johnson CH, Zhang Y. Use of Untargeted Metabolomics to Explore the Air Pollution-Related Disease Continuum. Current Environmental Health Reports 2021, 8: 7-22. PMID: 33420964, DOI: 10.1007/s40572-020-00298-x.Peer-Reviewed Original ResearchConceptsAir pollutant exposureAdverse health effectsSpecific adverse health effectsOxidative stressHealth effectsPerturbation of metabolitesAir pollution exposureUntargeted metabolomicsPollutant exposureSteroid metabolic pathwaysPregnant womenInflammatory responseDisease continuumReviewThe purposeHealth outcomesLarger sample sizeMetabolic pathwaysDisease statusPollution exposureIdentified metabolitesMetabolic perturbationsMetabolic changesSummaryOur reviewAir pollution componentsMetabolomic analysis
2020
Exploring the external exposome using wearable passive samplers - The China BAPE study
Koelmel JP, Lin EZ, Guo P, Zhou J, He J, Chen A, Gao Y, Deng F, Dong H, Liu Y, Cha Y, Fang J, Beecher C, Shi X, Tang S, Godri Pollitt KJ. Exploring the external exposome using wearable passive samplers - The China BAPE study. Environmental Pollution 2020, 270: 116228. PMID: 33360595, DOI: 10.1016/j.envpol.2020.116228.Peer-Reviewed Original ResearchMeSH KeywordsAgedAir PollutantsChinaEnvironmental MonitoringExposomeHumansMiddle AgedWearable Electronic DevicesConceptsPassive samplersPersonal care productsPersonal exposure profilesAirborne contaminant exposurePassive air samplersChemicals of concernToxicity of chemicalsPolyaromatic hydrocarbonsCare productsChina BAPE studyElevated toxicityPersonal exposureChemicalsSources of exposureParticulate phaseInhalation routeExternal exposomeGreater health risksCigarette smokeContaminant exposureAntimicrobial soapHealthy participantsRouteAir samplerEnvironmental exposuresAmbient particulate matter oxidative potential: Chemical determinants, associated health effects, and strategies for risk management
Gao D, Ripley S, Weichenthal S, Godri Pollitt KJ. Ambient particulate matter oxidative potential: Chemical determinants, associated health effects, and strategies for risk management. Free Radical Biology And Medicine 2020, 151: 7-25. PMID: 32430137, DOI: 10.1016/j.freeradbiomed.2020.04.028.Peer-Reviewed Original ResearchMeSH KeywordsAgedAir PollutantsHumansOxidation-ReductionOxidative StressParticulate MatterRisk ManagementConceptsOxidative potentialRedox-active metalsRedox propertiesPM chemical constituentsOrganic speciesPM oxidative potentialTarget moleculesFine PM massOP assaysChemical constituentsChemical determinantsParticulate matter toxicityOP responseMass concentrationAssociated health effectsPM speciesAir pollution exposure assessmentMetalsEpidemiological studiesHealth outcomesEpidemiologic literaturePollution exposure assessmentHealth effectsRedoxExposure assessment
2018
Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study
Liu L, Urch B, Szyszkowicz M, Evans G, Speck M, Van Huang A, Leingartner K, Shutt RH, Pelletier G, Gold DR, Brook JR, Godri Pollitt K, Silverman FS. Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study. Environment International 2018, 121: 1331-1340. PMID: 30420132, PMCID: PMC6396878, DOI: 10.1016/j.envint.2018.10.055.Peer-Reviewed Original ResearchConceptsUbiquitin C-terminal hydrolase L1Vascular endothelium growth factorBiomarker levelsPost exposureSystemic inflammationOxidative stressNeural biomarkersS100 calcium-binding protein BCalcium-binding protein BNeural functionHealthy non-smoking volunteersConcentrated ambient PMAssessment of biomarkersNon-smoking volunteersStress marker cortisolAmbient PMUrinary malondialdehydeUrinary biomarkersUrinary cortisolInterleukin-6Mixed regression modelsVanillylmandelic acidInflammationMean concentrationGrowth factorFine Particulate Air Pollution and Adverse Birth Outcomes: Effect Modification by Regional Nonvolatile Oxidative Potential
Lavigne É, Burnett RT, Stieb DM, Evans GJ, Godri Pollitt KJ, Chen H, van Rijswijk D, Weichenthal S. Fine Particulate Air Pollution and Adverse Birth Outcomes: Effect Modification by Regional Nonvolatile Oxidative Potential. Environmental Health Perspectives 2018, 126: 077012. PMID: 30073952, PMCID: PMC6108848, DOI: 10.1289/ehp2535.Peer-Reviewed Original ResearchConceptsTerm low birth weightLow birth weightAdverse birth outcomesPreterm birthBirth outcomesHighest quartileBirth weightEffect modificationFirst trimester PMRetrospective cohort studyTerm birth weightFine particulate air pollutionPossible effect modificationDays of deliveryFine particulate matter air pollutionParticulate matter air pollutionMatter air pollutionEffects of PMEstimate of effectParticulate air pollutionPreterm deliveryCohort studySingleton birthsPrenatal exposureImpact of PMComparison of Airway Responses Induced in a Mouse Model by the Gas and Particulate Fractions of Gasoline Direct Injection Engine Exhaust
Maikawa CL, Zimmerman N, Ramos M, Shah M, Wallace JS, Pollitt KJG. Comparison of Airway Responses Induced in a Mouse Model by the Gas and Particulate Fractions of Gasoline Direct Injection Engine Exhaust. International Journal Of Environmental Research And Public Health 2018, 15: 429. PMID: 29494515, PMCID: PMC5876974, DOI: 10.3390/ijerph15030429.Peer-Reviewed Original ResearchConceptsAirway hyperresponsivenessAllergic asthma murine modelAsthma murine modelNon-allergic miceMethacholine responsivenessAirway responsesPulmonary responsePeripheral tissuesMurine modelMouse modelShort-term exposureAcute exposureGDI engine exhaustPolycyclic aromatic hydrocarbon metabolismUpregulation of genesHyperresponsivenessParticulate fractionHealth impactsAromatic hydrocarbon metabolismPrevalenceMiceExposureDiesel exhaustAnimalsResponse
2017
Assessment of indoor and outdoor particulate air pollution at an urban background site in Iran
Mohammadyan M, Ghoochani M, Kloog I, Abdul-Wahab SA, Yetilmezsoy K, Heibati B, Godri Pollitt KJ. Assessment of indoor and outdoor particulate air pollution at an urban background site in Iran. Environmental Monitoring And Assessment 2017, 189: 235. PMID: 28451957, DOI: 10.1007/s10661-017-5951-1.Peer-Reviewed Original Research