Assessment of the in vitro toxicity of the disinfection byproduct 2,6-dichloro-1,4-benzoquinone and its transformed derivatives
Hung S, Mohan A, Reckhow DA, Godri Pollitt KJ. Assessment of the in vitro toxicity of the disinfection byproduct 2,6-dichloro-1,4-benzoquinone and its transformed derivatives. Chemosphere 2019, 234: 902-908. PMID: 31519098, DOI: 10.1016/j.chemosphere.2019.06.086.Peer-Reviewed Original ResearchMeSH KeywordsBenzoquinonesDisinfectantsDisinfectionDrinking WaterHumansHydrolysisReactive Oxygen SpeciesWater Pollutants, ChemicalWater PurificationConceptsReactive oxygen speciesNormal human colon cellsHuman liver cancer cellsConcentration-dependent decreaseLiver cancer cellsIntracellular reactive oxygen speciesHuman colon cellsStudy designCell culture mediumCancer cellsColon cellsROS productionCulture mediumGreater cytotoxicityCell linesAcute cytotoxicityCell viabilityToxicological profileToxicological studiesCytotoxicityToxicityEnhanced toxicityOxygen speciesCell mediumPotential underestimation