2017
The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening
Gonzalez D, Gregory J, Brennand K. The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening. Frontiers In Cell And Developmental Biology 2017, 5: 117. PMID: 29312938, PMCID: PMC5742170, DOI: 10.3389/fcell.2017.00117.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2015
Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder
Mertens J, Wang Q, Kim Y, Yu D, Pham S, Yang B, Zheng Y, Diffenderfer K, Zhang J, Soltani S, Eames T, Schafer S, Boyer L, Marchetto M, Nurnberger J, Calabrese J, Oedegaard K, McCarthy M, Zandi P, Alda M, Nievergelt C, Mi S, Brennand K, Kelsoe J, Gage F, Yao J. Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature 2015, 527: 95-99. PMID: 26524527, PMCID: PMC4742055, DOI: 10.1038/nature15526.Peer-Reviewed Original ResearchFrom “Directed Differentiation” to “Neuronal Induction”: Modeling Neuropsychiatric Disease
Ho S, Topol A, Brennand K. From “Directed Differentiation” to “Neuronal Induction”: Modeling Neuropsychiatric Disease. Biomarker Insights 2015, 10s1: bmi.s20066. PMID: 26045654, PMCID: PMC4444490, DOI: 10.4137/bmi.s20066.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNeuronal inductionSomatic cell reprogrammingNeuropsychiatric diseasesPsychiatric disordersPluripotent stem cell (iPSC) technologyCell reprogrammingDirected DifferentiationMost neurological diseasesStem cell technologyHuman postmortem samplesFunction of neuronsPolygenic originHuman neuronsDisease onsetAnimal modelsNeurological diseasesDisease initiationPostmortem samplesDiseaseNeuronsDifferentiationPrimary causeLimitless numberDisordersAberrant behavior