2024
A Hybrid Transformer-Convolutional Neural Network for Segmentation of Intracerebral Hemorrhage and Perihematomal Edema on Non-Contrast Head Computed Tomography (CT) with Uncertainty Quantification to Improve Confidence
Tran A, Desser D, Zeevi T, Abou Karam G, Dierksen F, Dell’Orco A, Kniep H, Hanning U, Fiehler J, Zietz J, Sanelli P, Malhotra A, Duncan J, Aneja S, Falcone G, Qureshi A, Sheth K, Nawabi J, Payabvash S. A Hybrid Transformer-Convolutional Neural Network for Segmentation of Intracerebral Hemorrhage and Perihematomal Edema on Non-Contrast Head Computed Tomography (CT) with Uncertainty Quantification to Improve Confidence. Bioengineering 2024, 11: 1274. DOI: 10.3390/bioengineering11121274.Peer-Reviewed Original ResearchNon-contrast head computed tomographyPerihematomal edemaHead computed tomographyIntracerebral hemorrhageComputed tomographyVolume similarityUniversity Medical Center Hamburg-EppendorfSecondary brain injuryYale cohortInfratentorial locationMulticentre trialCT scanTreatment planningNon-contrastHamburg-EppendorfImaging markersHemorrhagic strokeHemorrhageEdemaCohortBrain injuryDice coefficientDeep learning survival model predicts outcome after intracerebral hemorrhage from initial CT scan.
Chen Y, Rivier C, Mora S, Torres Lopez V, Payabvash S, Sheth K, Harloff A, Falcone G, Rosand J, Mayerhofer E, Anderson C. Deep learning survival model predicts outcome after intracerebral hemorrhage from initial CT scan. European Stroke Journal 2024, 23969873241260154. PMID: 38880882, PMCID: PMC11569453, DOI: 10.1177/23969873241260154.Peer-Reviewed Original ResearchIntracerebral hemorrhage scoreNon-contrast CT scanIntracerebral hemorrhageCT scanFUNC scoreIntracerebral hemorrhage patientsNon-contrast CTFunctional impairmentSevere disabilityDependent living statusLong-term functional impairmentC-indexPrognostic toolFunctional outcomesTreatment decisionsAcute settingClinical implementationRehabilitation strategiesDependent livingPatientsPredicting functional impairmentLong-term care needsPlanning of patient careDeep learning modelsHemorrhageOral Health as a Risk Factor for Spontaneous Intracerebral Hemorrhage: A Mendelian Randomization Analysis (S34.001)
Rivier C, Clocchiatti-Tuozzo S, Huo S, Renedo D, Hawkes M, Sunmonu N, Sheth K, Falcone G. Oral Health as a Risk Factor for Spontaneous Intracerebral Hemorrhage: A Mendelian Randomization Analysis (S34.001). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000204999.Peer-Reviewed Original ResearchFactors Associated with Delayed Clinical Evaluation for Patients with Intracerebral Hemorrhage in the ERICH Study (S41.010)
Lalwani D, Zabinska J, Peasley E, De Havenon A, Falcone G, Goldstein J, Woo D, Sheth K. Factors Associated with Delayed Clinical Evaluation for Patients with Intracerebral Hemorrhage in the ERICH Study (S41.010). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000204689.Peer-Reviewed Original Research
2023
Intensive Blood Pressure Reduction is Associated with Reduced Hematoma Growth in Fast Bleeding Intracerebral Hemorrhage
Li Q, Morotti A, Warren A, Qureshi A, Dowlatshahi D, Falcone G, Sheth K, Shoamanesh A, Murthy S, Viswanathan A, Goldstein J. Intensive Blood Pressure Reduction is Associated with Reduced Hematoma Growth in Fast Bleeding Intracerebral Hemorrhage. Annals Of Neurology 2023, 95: 129-136. PMID: 37706569, DOI: 10.1002/ana.26795.Peer-Reviewed Original ResearchBlood pressure reductionIntensive Blood Pressure ReductionIntensive BP reductionIntracerebral hemorrhageHematoma growthBP reductionPressure reductionImproved functional independenceIntensive BP loweringLarge clinical trialsSpontaneous intracerebral hemorrhageAntihypertensive treatmentHemorrhage 2BP loweringSymptom onsetHematoma volumeHematoma expansionClinical trialsHigh riskTomography timePatientsFunctional independenceEarly useHemorrhageLower rates
2022
Impaired Cerebral Autoregulation Related Blood Pressure Reductions After Nimodipine Are Associated with Ischemic Changes on EEG After Subarachnoid Hemorrhage (P13-10.002)
Top I, Chen Y, Bartolome D, Rapuano A, Gilmore E, Sheth K, Matouk C, Petersen N, Kim J. Impaired Cerebral Autoregulation Related Blood Pressure Reductions After Nimodipine Are Associated with Ischemic Changes on EEG After Subarachnoid Hemorrhage (P13-10.002). Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.3539.Peer-Reviewed Original Research
2021
Chronic Kidney Disease is Associated with Higher Risk and Worse Outcome after Spontaneous Intracerebral Hemorrhage (2729)
Leasure A, Vanent K, Acosta J, Woo D, Murthy S, Kamel H, Cohen J, Townsend R, Petersen N, Sansing L, Gill T, Sheth K, Falcone G. Chronic Kidney Disease is Associated with Higher Risk and Worse Outcome after Spontaneous Intracerebral Hemorrhage (2729). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.2729.Peer-Reviewed Original ResearchExtracranial Hemorrhage in the Setting of Gastrointestinal or Genitourinary Cancer is Associated with Increased Risk of Ischemic Stroke in Patients with Atrial Fibrillation (1373)
Zhou E, Lord A, Boehme A, Henninger N, De Havenon A, Vahidy F, Ishida K, Torres J, Mistry E, Mac Grory B, Sheth K, Gurol E, Furie K, Elkind M, Yaghi S. Extracranial Hemorrhage in the Setting of Gastrointestinal or Genitourinary Cancer is Associated with Increased Risk of Ischemic Stroke in Patients with Atrial Fibrillation (1373). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.1373.Peer-Reviewed Original Research
2019
Dynamic Cerebral Autoregulation and Personalized Blood Pressure Monitoring in Patients with Aneurysmal Subarachnoid Hemorrhage (aSAH) (P5.3-025)
Silverman A, Wang A, Kodali S, Strander S, Cord B, Hebert R, Matouk C, Sheth K, Gilmore E, Petersen N. Dynamic Cerebral Autoregulation and Personalized Blood Pressure Monitoring in Patients with Aneurysmal Subarachnoid Hemorrhage (aSAH) (P5.3-025). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.p5.3-025.Peer-Reviewed Original ResearchDiabetes Mellitus Predicts Symptomatic Intracerebral Hemorrhage Following Thrombectomy in Acute Ischemic Stroke (P1.3-035)
Montalvo M, Yakhkind A, Jayaraman M, McTaggart R, Chang A, Akiki R, Mac Grory B, Cutting S, Burton T, Reznik M, Thompson B, Wendell L, Rao S, Potter N, Mahta A, Sheth K, Willey J, Khatri P, Furie K, Yaghi S. Diabetes Mellitus Predicts Symptomatic Intracerebral Hemorrhage Following Thrombectomy in Acute Ischemic Stroke (P1.3-035). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.p1.3-035.Peer-Reviewed Original Research
2018
History of Intracranial Hemorrhage Is Associated with In-Hospital Mortality in Ischemic Stroke Patients Treated with Intravenous Thrombolytics
Sommaruga S, Chu S, Hwang D, Dearborn J, Sansing L, Cord B, Santarosa C, Samarth G, Petersen N, Gilmore E, Schindler J, Bijlenga P, Schaller K, Matouk C, Sheth K, Falcone G. History of Intracranial Hemorrhage Is Associated with In-Hospital Mortality in Ischemic Stroke Patients Treated with Intravenous Thrombolytics. Journal Of Neurological Surgery Part A Central European Neurosurgery 2018, 79: s1-s27. DOI: 10.1055/s-0038-1660745.Peer-Reviewed Original ResearchSafety Outcomes of Thrombolysis for Acute Ischemic Stroke in Patients with History of Intracranial Hemorrhage (P4.033)
Chu S, Sommaruga S, Hwang D, Dearborn J, Sansing L, Cord B, Samarth G, Petersen N, Gilmore E, Schindler J, Matouk C, Sheth K, Falcone G. Safety Outcomes of Thrombolysis for Acute Ischemic Stroke in Patients with History of Intracranial Hemorrhage (P4.033). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p4.033.Peer-Reviewed Original ResearchPlasma IL-6 Levels are Independently Associated with Functional Outcome and Markers of Secondary Injury in Spontaneous Intracerebral Hemorrhage (P4.296)
Leasure A, Steinschneider A, Falcone G, Gilmore E, Sansing L, Sheth K. Plasma IL-6 Levels are Independently Associated with Functional Outcome and Markers of Secondary Injury in Spontaneous Intracerebral Hemorrhage (P4.296). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p4.296.Peer-Reviewed Original Research
2017
Intracerebral Hemorrhage
Stevenson D, Sheth K. Intracerebral Hemorrhage. 2017, 75-91. DOI: 10.1007/978-3-319-48669-7_5.Peer-Reviewed Original ResearchSecondary intracerebral hemorrhageIntracerebral hemorrhageNontraumatic intracerebral hemorrhageIschemic strokeChronic small vessel diseasePrimary intracerebral hemorrhageSmall vessel diseaseCritical care settingHemorrhagic transformationCerebral edemaBlood pressureThorough historyBlood glucoseBrain parenchymaPhysical examVascular malformationsDistinct pathophysiologyIntracranial pressureAnatomical anomaliesCare settingsHemorrhageStrokeFinal manifestationEdemaPatientsResumption of Oral Anticoagulation after Intracerebral Hemorrhage is Associated with Decreased Mortality and Favorable Functional Outcome (CCI.003)
Biffi A, Kuramatsu J, Leasure A, Kamel H, Kourkoulis C, Schwab K, Ayres A, Gurol E, Greenberg S, Viswanathan A, Anderson C, Schwab S, Rosand J, Woo D, Huttner H, Sheth K. Resumption of Oral Anticoagulation after Intracerebral Hemorrhage is Associated with Decreased Mortality and Favorable Functional Outcome (CCI.003). Neurology 2017, 88 DOI: 10.1212/wnl.88.16_supplement.cci.003.Peer-Reviewed Original Research