1994
Measurement of GABA following GABA‐transaminase inhibition by gabaculine: A 1H and 31P NMR spectroscopic study of rat brain in vivo
Behar K, Boehm D. Measurement of GABA following GABA‐transaminase inhibition by gabaculine: A 1H and 31P NMR spectroscopic study of rat brain in vivo. Magnetic Resonance In Medicine 1994, 31: 660-667. PMID: 7914662, DOI: 10.1002/mrm.1910310612.Peer-Reviewed Original ResearchMeSH Keywords4-Aminobutyrate TransaminaseAnimalsAspartic AcidBrainBrain ChemistryCreatineCyclohexanecarboxylic AcidsGamma-Aminobutyric AcidGlutamatesGlutamic AcidHydrogenHydrogen-Ion ConcentrationMagnetic Resonance SpectroscopyMaleNucleotidesPhosphatesPhosphocreatinePhosphorusRatsRats, Sprague-Dawley
1990
The Flux from Glucose to Glutamate in the Rat Brain in vivo as Determined by 1-Observed, 13C-Edited NMR Spectroscopy
Fitzpatrick S, Hetherington H, Behar K, Shulman R. The Flux from Glucose to Glutamate in the Rat Brain in vivo as Determined by 1-Observed, 13C-Edited NMR Spectroscopy. Cerebrovascular And Brain Metabolism Reviews 1990, 10: 170-179. PMID: 1968068, DOI: 10.1038/jcbfm.1990.32.Peer-Reviewed Original ResearchConceptsNMR spectroscopyNuclear magnetic resonance spectroscopyMagnetic resonance spectroscopyFirst-order rate constantsResonance spectroscopySpectroscopyRate constantsRapid exchangeDifference spectraTotal glutamate concentrationCarbonIsotopic enrichmentMin-1SpectraResonanceUnresolved resonancesMeasured intensitySteady stateComplete time courseConstants
1989
Effects of Acute Hyperammonemia on Cerebral Amino Acid Metabolism and pHi In Vivo, Measured by 1H and 31P Nuclear Magnetic Resonance
Fitzpatrick S, Hetherington H, Behar K, Shulman R. Effects of Acute Hyperammonemia on Cerebral Amino Acid Metabolism and pHi In Vivo, Measured by 1H and 31P Nuclear Magnetic Resonance. Journal Of Neurochemistry 1989, 52: 741-749. PMID: 2563756, DOI: 10.1111/j.1471-4159.1989.tb02517.x.Peer-Reviewed Original ResearchConceptsAmmonia infusionCerebral amino acid metabolismCerebral glutamate levelsAcute intravenous infusionBrain glutamate concentrationsBrain lactate levelsMin of infusionContent of phosphocreatineBrain lactate contentGlutamine concentrationPreinfusion controlAcute hyperammonemiaIntravenous infusionCerebral glutamateControl infusionGlutamate levelsInfusion protocolArterial PCO2Lactate levelsPreinfusion valuesBrain glutamineBlood ammoniaMagnetic resonanceInfusionGlutamate concentration
1987
Combined 1H and 31P NMR Studies of the Rat Brain in Vivo: Effects of Altered Intracellular pH on Metabolisma
BEHAR K, ROTHMAN D, FITZPATRICK S, HETHERINGTON H, SHULMAN R. Combined 1H and 31P NMR Studies of the Rat Brain in Vivo: Effects of Altered Intracellular pH on Metabolisma. Annals Of The New York Academy Of Sciences 1987, 508: 81-88. PMID: 3125776, DOI: 10.1111/j.1749-6632.1987.tb32896.x.Chapters
1985
Cerebral metabolism in hyper- and hypocarbia: 31P and 1H nuclear magnetic resonance studies.
Petroff O, Prichard J, Behar K, Rothman D, Alger J, Shulman R. Cerebral metabolism in hyper- and hypocarbia: 31P and 1H nuclear magnetic resonance studies. Neurology 1985, 35: 1681-8. PMID: 2933595, DOI: 10.1212/wnl.35.12.1681.Peer-Reviewed Original ResearchCerebral intracellular pH by 31P nuclear magnetic resonance spectroscopy.
Petroff O, Prichard J, Behar K, Alger J, den Hollander J, Shulman R. Cerebral intracellular pH by 31P nuclear magnetic resonance spectroscopy. Neurology 1985, 35: 781-8. PMID: 4000479, DOI: 10.1212/wnl.35.6.781.Peer-Reviewed Original Research
1984
In vivo phosphorus nuclear magnetic resonance spectroscopy in status epilepticus
Petroff O, Prichard J, Behar K, Alger J, Shulman R. In vivo phosphorus nuclear magnetic resonance spectroscopy in status epilepticus. Annals Of Neurology 1984, 16: 169-177. PMID: 6476792, DOI: 10.1002/ana.410160203.Peer-Reviewed Original ResearchConceptsStatus epilepticusSeizure activityVivo phosphorus nuclear magnetic resonance spectroscopyControl valuesBicuculline-induced status epilepticusAdequate cerebral perfusionAnticonvulsant drug effectsDoses of bicucullineBlood pressureCerebral perfusionSeizure dischargesPhosphorus nuclear magnetic resonance spectroscopyPhosphocreatine levelsParalyzed rabbitsBrain phosphocreatineDrug effectsNitrous oxide mixtureEpilepticusTriphosphate levelsVivo brainTwo-thirdsPhysiological variablesMagnetic resonance spectroscopyGradual declineIntracellular