1996
Low brain GABA level is associated with poor seizure control
Petroff O, Rothman D, Behar K, Mattson R. Low brain GABA level is associated with poor seizure control. Annals Of Neurology 1996, 40: 908-911. PMID: 9007096, DOI: 10.1002/ana.410400613.Peer-Reviewed Original ResearchConceptsLower GABA levelsBrain GABA levelsLower brain GABA levelsPoor seizure controlGABA levelsSeizure controlRecent seizuresGamma-aminobutyric acid concentrationComplex partial seizuresPartial seizuresEpileptic syndromesEpileptic focusOccipital lobeCerebrospinal fluidPatientsSeizuresSignificant associationMagnetic resonanceVivo measurementsSurface coilLevelsEpilepsySyndromeGABAAcid concentrationThe effect of gabapentin on brain gamma‐aminobutyric acid in patients with epilepsy
Petroff O, Rothman D, Behar K, Lamoureux D, Mattson R. The effect of gabapentin on brain gamma‐aminobutyric acid in patients with epilepsy. Annals Of Neurology 1996, 39: 95-99. PMID: 8572673, DOI: 10.1002/ana.410390114.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidBrain GABA levelsGABA levelsHuman brain GABA levelsBrain gamma-aminobutyric acidHigh-dose gabapentinAntiepileptic drug treatmentEffect of gabapentinPartial epilepsy patientsTreatment of epilepsyMechanism of actionAdjunctive therapyStandard dosesDrug treatmentEpilepsy patientsOccipital cortexGabapentinPatientsClinical useEpilepsyHuman brainMagnetic resonanceTreatmentMagnetic resonance spectroscopyVivo measurements
1989
Effects of Acute Hyperammonemia on Cerebral Amino Acid Metabolism and pHi In Vivo, Measured by 1H and 31P Nuclear Magnetic Resonance
Fitzpatrick S, Hetherington H, Behar K, Shulman R. Effects of Acute Hyperammonemia on Cerebral Amino Acid Metabolism and pHi In Vivo, Measured by 1H and 31P Nuclear Magnetic Resonance. Journal Of Neurochemistry 1989, 52: 741-749. PMID: 2563756, DOI: 10.1111/j.1471-4159.1989.tb02517.x.Peer-Reviewed Original ResearchConceptsAmmonia infusionCerebral amino acid metabolismCerebral glutamate levelsAcute intravenous infusionBrain glutamate concentrationsBrain lactate levelsMin of infusionContent of phosphocreatineBrain lactate contentGlutamine concentrationPreinfusion controlAcute hyperammonemiaIntravenous infusionCerebral glutamateControl infusionGlutamate levelsInfusion protocolArterial PCO2Lactate levelsPreinfusion valuesBrain glutamineBlood ammoniaMagnetic resonanceInfusionGlutamate concentration