1999
In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate--glutamine neurotransmitter cycle and functional neuroenergetics
Rothman D, Sibson N, Hyder F, Shen J, Behar K, Shulman R. In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate--glutamine neurotransmitter cycle and functional neuroenergetics. Philosophical Transactions Of The Royal Society B Biological Sciences 1999, 354: 1165-1177. PMID: 10466144, PMCID: PMC1692640, DOI: 10.1098/rstb.1999.0472.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGlutamate-glutamine cycleNerve terminalsNeurotransmitter cycleGlucose metabolismBlood oxygenation level-dependent magnetic resonance imagingLevel-dependent magnetic resonance imagingBrain glucose oxidationCortical glucose metabolismMagnetic resonance spectroscopy studyCortex of ratsMagnetic resonance imagingFunctional imaging studiesSpecific neuronal activityOxidative glucose metabolismGlial cellsNeuronal activityResonance imagingImaging studiesHuman cortexBrain functionBrain activityRatsCortexGlucose oxidationGlutamateHexokinase in Astrocytes: Kinetic and Regulatory Properties
Lai J, Behar K, Liang B, Hertz L. Hexokinase in Astrocytes: Kinetic and Regulatory Properties. Metabolic Brain Disease 1999, 14: 125-133. PMID: 10488914, DOI: 10.1023/a:1020761831295.Peer-Reviewed Original Research
1998
Functional Energy Metabolism:In vivo 13C-NMR Spectroscopy Evidence for Coupling of Cerebral Glucose Consumption and Gl utamatergic Neuronal Activity
Sibson N, Shen J, Mason G, Rothman D, Behar K, Shulman R. Functional Energy Metabolism:In vivo 13C-NMR Spectroscopy Evidence for Coupling of Cerebral Glucose Consumption and Gl utamatergic Neuronal Activity. Developmental Neuroscience 1998, 20: 321-330. PMID: 9778568, DOI: 10.1159/000017327.Peer-Reviewed Original ResearchConceptsRat brain cortexGlucose metabolismBrain cortexNeurotransmitter cyclingTotal glucose oxidationGlutamatergic synaptic activityCerebral glucose consumptionCerebral glucose metabolismFunctional activityFunctional imaging methodsGlucose oxidationOxidative glucose metabolismGlutamate neurotransmitter cyclingSynaptic activityNeuronal activityMild anesthesiaGlutamine synthesisMammalian brainNeurotransmitter releaseGlutamate cyclingEEG activityAmmonia metabolismNeurophysiological basisDetoxification componentsVivo resultsMapping Glutamatergic Activity: Stoichiometric Coupling of Brain Glucose Metabolism and Neurotransmitter Glutamate Cycling
Sibson N, Mason G, Behar K, Rothman D, Shulman R. Mapping Glutamatergic Activity: Stoichiometric Coupling of Brain Glucose Metabolism and Neurotransmitter Glutamate Cycling. NeuroImage 1998, 7: s287. DOI: 10.1016/s1053-8119(18)31120-0.Peer-Reviewed Original Research
1993
Rat Brain Glucose Concentration and Transport Kinetics Determined with 13C Nuclear Magnetic Resonance Spectroscopy
Mason G, Behar K, Martin M, Shulman R. Rat Brain Glucose Concentration and Transport Kinetics Determined with 13C Nuclear Magnetic Resonance Spectroscopy. Advances In Experimental Medicine And Biology 1993, 331: 29-34. PMID: 8333345, DOI: 10.1007/978-1-4615-2920-0_6.Peer-Reviewed Original Research
1992
NMR Determination of the TCA Cycle Rate and α-Ketoglutarate/Glutamate Exchange Rate in Rat Brain
Mason G, Rothman D, Behar K, Shulman R. NMR Determination of the TCA Cycle Rate and α-Ketoglutarate/Glutamate Exchange Rate in Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 434-447. PMID: 1349022, DOI: 10.1038/jcbfm.1992.61.Peer-Reviewed Original Research