Effects of Acute Hyperammonemia on Cerebral Amino Acid Metabolism and pHi In Vivo, Measured by 1H and 31P Nuclear Magnetic Resonance
Fitzpatrick S, Hetherington H, Behar K, Shulman R. Effects of Acute Hyperammonemia on Cerebral Amino Acid Metabolism and pHi In Vivo, Measured by 1H and 31P Nuclear Magnetic Resonance. Journal Of Neurochemistry 1989, 52: 741-749. PMID: 2563756, DOI: 10.1111/j.1471-4159.1989.tb02517.x.Peer-Reviewed Original ResearchConceptsAmmonia infusionCerebral amino acid metabolismCerebral glutamate levelsAcute intravenous infusionBrain glutamate concentrationsBrain lactate levelsMin of infusionContent of phosphocreatineBrain lactate contentGlutamine concentrationPreinfusion controlAcute hyperammonemiaIntravenous infusionCerebral glutamateControl infusionGlutamate levelsInfusion protocolArterial PCO2Lactate levelsPreinfusion valuesBrain glutamineBlood ammoniaMagnetic resonanceInfusionGlutamate concentration