Effects of Acute Hyperammonemia on Cerebral Amino Acid Metabolism and pHi In Vivo, Measured by 1H and 31P Nuclear Magnetic Resonance
Fitzpatrick S, Hetherington H, Behar K, Shulman R. Effects of Acute Hyperammonemia on Cerebral Amino Acid Metabolism and pHi In Vivo, Measured by 1H and 31P Nuclear Magnetic Resonance. Journal Of Neurochemistry 1989, 52: 741-749. PMID: 2563756, DOI: 10.1111/j.1471-4159.1989.tb02517.x.Peer-Reviewed Original ResearchConceptsAmmonia infusionCerebral amino acid metabolismCerebral glutamate levelsAcute intravenous infusionBrain glutamate concentrationsBrain lactate levelsMin of infusionContent of phosphocreatineBrain lactate contentGlutamine concentrationPreinfusion controlAcute hyperammonemiaIntravenous infusionCerebral glutamateControl infusionGlutamate levelsInfusion protocolArterial PCO2Lactate levelsPreinfusion valuesBrain glutamineBlood ammoniaMagnetic resonanceInfusionGlutamate concentrationEffects of Hypercarbia and Porta-Caval Shunting on Amino Acids and High Energy Phosphates of the Rat Brain: a 1H and 31P NMR Study
Behar K, Fitzpatrick S. Effects of Hypercarbia and Porta-Caval Shunting on Amino Acids and High Energy Phosphates of the Rat Brain: a 1H and 31P NMR Study. Experimental Biology And Medicine 1989, 189-200. DOI: 10.1007/978-1-4612-4506-3_13.Peer-Reviewed Original ResearchRat brainCerebral amino acidsEffects of hypercarbiaConcentration of glutamateHigh-energy phosphatesPorta-cavalCerebral hypoxiaMetabolic encephalopathiesHypercarbic acidosisAcute hyperammonemiaCerebral glutamateIntracellular acidosisEnergy phosphatesIncrease of glutamineHypercarbiaEncephalopathyAcidosisHyperammonemiaGlutamateBrainAmino acidsIntracellularIschemiaSeizuresShunting