2024
Late Cardiac Toxic Effects Associated With Treatment Protocols for Hodgkin Lymphoma in Children
Lo A, Liu A, Liu Q, Yasui Y, Castellino S, Kelly K, Hererra A, Friedberg J, Friedman D, Schwartz C, Pei Q, Kessel S, Bergeron-Gravel S, Dama H, Roberts K, Constine L, Hodgson D. Late Cardiac Toxic Effects Associated With Treatment Protocols for Hodgkin Lymphoma in Children. JAMA Network Open 2024, 7: e2351062. PMID: 38241048, PMCID: PMC10799264, DOI: 10.1001/jamanetworkopen.2023.51062.Peer-Reviewed Original ResearchConceptsCardiac toxic effectsMediastinal RTHodgkin lymphomaRadiation therapyCumulative incidenceCardiac diseaseDoxorubicin doseCohort studyClinical trialsMedian mean heart doseChildren's Oncology Group clinical trialStudy populationHigh-risk HLMean heart dosePlanned cumulative doseRadiation therapy useIncidence of cardiac diseaseCumulative doxorubicin doseRisks associated with treatmentNorth American trialsGroup clinical trialFollow-up guidelinesStandard treatment groupToxic effectsMaintained long term
2023
Risk of Subsequent Neoplasms in Childhood Cancer Survivors After Radiation Therapy: A PENTEC Comprehensive Review
Casey D, Vogelius I, Brodin N, Roberts K, Avanzo M, Moni J, Owens C, Ronckers C, Constine L, Bentzen S, Olch A. Risk of Subsequent Neoplasms in Childhood Cancer Survivors After Radiation Therapy: A PENTEC Comprehensive Review. International Journal Of Radiation Oncology • Biology • Physics 2023, 119: 640-654. PMID: 37777927, DOI: 10.1016/j.ijrobp.2023.07.025.Peer-Reviewed Original ResearchChildhood cancer survivorsCancer survivorsRadiation therapySubsequent meningiomaLung cancerCNS neoplasmsSubsequent neoplasmsSubsequent sarcomaRT dosePrimary diagnosisHigh riskPediatric Normal Tissue EffectsRadiation dose-response relationshipSubsequent lung cancerPrior radiation therapyTreatment-related factorsExcess absolute riskPrimary cancer diagnosisERR/GyNormal tissue effectsSpecific chemotherapeutic agentsDose-response relationshipHigh-dose volumeSignificant contributory roleERR/Importance of Central Imaging Review in a Pediatric Hodgkin Lymphoma Trial Using Positron Emission Tomography Response Adapted Radiation Therapy
Hoppe B, McCarten K, Pei Q, Kessel S, Alazraki A, Mhlanga J, Lai H, Eutsler E, Hodgson D, Roberts K, Charpentier A, Keller F, Voss S, Wu Y, Cho S, Kelly K, Castellino S. Importance of Central Imaging Review in a Pediatric Hodgkin Lymphoma Trial Using Positron Emission Tomography Response Adapted Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2023, 116: 1025-1030. PMID: 36868525, PMCID: PMC10363760, DOI: 10.1016/j.ijrobp.2023.02.020.Peer-Reviewed Original ResearchConceptsCentral reviewDeauville scoreCentral imaging reviewRadiation therapyResponse assessmentHodgkin's lymphomaImaging reviewInstitutional reviewFluorodeoxyglucose positron emission tomography/High-risk Hodgkin lymphomaPositron emission tomography responseConcordance rateEmission tomography/Real-time central reviewCohen κ statisticAreas of diseaseSystemic therapyTreating institutionPediatric patientsLymphoma trialsTomography responseTomography/Treatment allocationClinical trialsPatients
2022
Risk of Subsequent Central Nervous System Neoplasms in Childhood Cancer Survivors after Radiation Therapy: Results from the Pediatric Normal Tissue Effects in the Clinic (PENTEC) Collaboration
Casey D, Brodin P, Roberts K, Vogelius I, Avanzo M, Moni J, Owens C, Ronckers C, Constine L, Bentzen S, Olch A. Risk of Subsequent Central Nervous System Neoplasms in Childhood Cancer Survivors after Radiation Therapy: Results from the Pediatric Normal Tissue Effects in the Clinic (PENTEC) Collaboration. International Journal Of Radiation Oncology • Biology • Physics 2022, 114: s122-s123. DOI: 10.1016/j.ijrobp.2022.07.568.Peer-Reviewed Original ResearchSubsequent malignant tumorChildhood cancer survivorsMalignant CNS tumorsSubsequent meningiomaExcess odds ratioMalignant tumorsRadiation therapyCancer survivorsRT doseCNS tumorsOdds ratioHigh riskPediatric Normal Tissue EffectsPrior cranial radiation therapyCentral nervous system neoplasmsRadiation dose-response relationshipMalignant CNS tumorPrimary cancer diagnosisCranial radiation therapyNervous system neoplasmsIndependent patient cohortsDifferent dose intervalsNormal tissue effectsDose-response relationshipMATERIAL/METHODS
2021
Pediatric Hodgkin Lymphoma, Version 3.2021.
Flerlage J, Hiniker S, Armenian S, Benya E, Bobbey A, Chang V, Cooper S, Coulter D, Cuglievan B, Hoppe B, Isenalumhe L, Kelly K, Kersun L, Lamble A, Larrier N, Magee J, Oduro K, Pacheco M, Price A, Roberts K, Smith C, Sohani A, Trovillion E, Walling E, Xavier A, Burns J, Campbell M. Pediatric Hodgkin Lymphoma, Version 3.2021. Journal Of The National Comprehensive Cancer Network 2021, 19: 733-754. PMID: 34214968, DOI: 10.6004/jnccn.2021.0027.Peer-Reviewed Original ResearchConceptsPediatric Hodgkin lymphomaClassic Hodgkin lymphomaHodgkin's lymphomaNCCN Clinical Practice GuidelinesClinical practice guidelinesCurrent treatment regimensNCCN guidelinesRefractory settingSystemic therapyCurable formTreatment regimensPrinciples of pathologyDiagnostic evaluationLate effectsPractice guidelinesRadiation therapyTreatment efficacyLymphomaTherapyTreatmentGuidelinesRegimensWorkupCancerStagingPediatric classical Hodgkin lymphoma
Lo AC, Dieckmann K, Pelz T, Gallop‐Evans E, Engenhart‐Cabillic R, Vordermark D, Kelly KM, Schwartz CL, Constine LS, Roberts K, Hodgson D. Pediatric classical Hodgkin lymphoma. Pediatric Blood & Cancer 2021, 68: e28562. PMID: 33818890, DOI: 10.1002/pbc.28562.Peer-Reviewed Original ResearchConceptsClassical Hodgkin lymphomaChildren's Oncology GroupPediatric classical Hodgkin lymphomaHodgkin's lymphomaRadiation therapyOncology GroupUtilization of RTHigh-risk patientsBulk of diseaseHigh cure ratesUniformly fatal diseaseLong-term toxicityIntensity of treatmentEuroNet-PHLB symptomsRisk patientsCurable cancerLymphoma trialsRT volumeCure rateTumor stageImmunoregulatory drugsTrial groupChemotherapy agentsHL managementPrimary Mediastinal B Cell Lymphoma in the Positron-Emission Tomography Era Executive Summary of the American Radium Society Appropriate Use Criteria
Hoppe BS, Advani R, Milgrom SA, Bakst RL, Ballas LK, Dabaja BS, Flowers CR, Ha CS, Mansur DB, Metzger ML, Pinnix CC, Plastaras JP, Roberts KB, Smith SM, Terezakis SA, Kirwan JM, Constine LS. Primary Mediastinal B Cell Lymphoma in the Positron-Emission Tomography Era Executive Summary of the American Radium Society Appropriate Use Criteria. International Journal Of Radiation Oncology • Biology • Physics 2021, 111: 36-44. PMID: 33774076, DOI: 10.1016/j.ijrobp.2021.03.035.Peer-Reviewed Original ResearchConceptsPrimary mediastinal B-cell lymphomaMediastinal B-cell lymphomaB-cell lymphomaPET/CT responsePositron emission tomographyCell lymphomaDeauville scaleRadiation therapyCT responseAmerican Radium Society Appropriate Use CriteriaLong-term treatment-related morbiditySystematic reviewTreatment-related morbidityConsolidative radiation therapyAppropriate use criteriaEvidence-based guidelinesNon-Hodgkin lymphomaMeta-Analyses (PRISMA) guidelinesPreferred Reporting ItemsChemoimmunotherapy strategiesCurable subtypeAdditional therapyChemoimmunotherapy regimensRefractory diseasePediatric oncologists
2020
Tumor-targeted pH-low insertion peptide delivery of theranostic gadolinium nanoparticles for image-guided nanoparticle-enhanced radiation therapy
Liu W, Deacon J, Yan H, Sun B, Liu Y, Hegan D, Li Q, Coman D, Parent M, Hyder F, Roberts K, Nath R, Tillement O, Engelman D, Glazer P. Tumor-targeted pH-low insertion peptide delivery of theranostic gadolinium nanoparticles for image-guided nanoparticle-enhanced radiation therapy. Translational Oncology 2020, 13: 100839. PMID: 32763504, PMCID: PMC7408331, DOI: 10.1016/j.tranon.2020.100839.Peer-Reviewed Original ResearchHuman lung cancer cellsA549 human lung cancer cellsMolecular MRI techniqueTumor-bearing miceLung cancer cellsClonogenic survival assaysVivo radiosensitizationRadiation therapySolid tumorsTumor cell metabolismTumorsEnhanced radiosensitivityTumor cellsMR imagingSurvival assaysMRI techniquesCancer cellsTreatment planningRadiotherapyTumor coreGeneral hallmarkRadiotherapy treatment planningRadiosensitivityPeptide deliveryDelivery
2016
ACR Appropriateness Criteria® Hodgkin Lymphoma-Favorable Prognosis Stage I and II
Dhakal S, Advani R, Ballas LK, Dabaja BS, Flowers CR, Ha CS, Hoppe BS, Mendenhall NP, Metzger ML, Plastaras JP, Roberts KB, Shapiro R, Smith SM, Terezakis SA, Winkfield KM, Younes A, Constine LS. ACR Appropriateness Criteria® Hodgkin Lymphoma-Favorable Prognosis Stage I and II. American Journal Of Clinical Oncology 2016, 39: 535-544. PMID: 27643717, PMCID: PMC7433865, DOI: 10.1097/coc.0000000000000331.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntineoplastic Combined Chemotherapy ProtocolsChemoradiotherapyDisease-Free SurvivalDose-Response Relationship, DrugFemaleHodgkin DiseaseHumansMaleNeoplasm InvasivenessNeoplasm StagingOutcome Assessment, Health CarePractice Guidelines as TopicRadiotherapy DosageRandomized Controlled Trials as TopicRisk AssessmentSocieties, MedicalSurvival AnalysisUnited StatesConceptsStage IModality therapyHodgkin's lymphomaAppropriateness CriteriaMedical literatureAppropriateness of imagingACR Appropriateness CriteriaRadiology Appropriateness CriteriaEvidence-based guidelinesMultidisciplinary expert panelSpecific clinical conditionsSpecific clinical scenariosCurrent medical literatureRecent medical literatureLess chemotherapyPeer-reviewed journalsLate effectsClinical conditionsRadiation therapyAmerican CollegeExpert opinionClinical scenariosExcellent efficacyGuideline developmentAvailable evidenceAddition of Chemotherapy to Adjuvant Radiation Therapy is Associated With Improved Overall Survival in Adult Medulloblastoma
Kann B, Lester-Coll N, Park H, Yeboa D, Bindra R, Becker K, Baehring J, Roberts K. Addition of Chemotherapy to Adjuvant Radiation Therapy is Associated With Improved Overall Survival in Adult Medulloblastoma. International Journal Of Radiation Oncology • Biology • Physics 2016, 96: s27-s28. DOI: 10.1016/j.ijrobp.2016.06.080.Peer-Reviewed Original Research
2015
Pediatric Brainstem Glioma Survival After Definitive Radiation Therapy With or Without Concurrent Chemotherapy: A Nationwide Comparison
Park H, Yeboa D, Lester-Coll N, Corso C, Mancini B, Bindra R, Roberts K, Yu J, Rutter C. Pediatric Brainstem Glioma Survival After Definitive Radiation Therapy With or Without Concurrent Chemotherapy: A Nationwide Comparison. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: e504-e505. DOI: 10.1016/j.ijrobp.2015.07.1836.Peer-Reviewed Original ResearchThe Effect of Margin Status and Radiation Therapy on Survival in Adult Retroperitoneal Soft Tissue Sarcomas
Stahl J, Corso C, An Y, Aneja S, Rutter C, Park H, Mancini B, Yeboa D, Lester-Coll N, Han D, Roberts K. The Effect of Margin Status and Radiation Therapy on Survival in Adult Retroperitoneal Soft Tissue Sarcomas. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: e638. DOI: 10.1016/j.ijrobp.2015.07.2175.Peer-Reviewed Original ResearchA report of metachronous orbital involvement by IgG4 disease treated successfully with low-dose radiation therapy
Rutter CE, Mancini BR, Roberts KB. A report of metachronous orbital involvement by IgG4 disease treated successfully with low-dose radiation therapy. Practical Radiation Oncology 2015, 6: 74-77. PMID: 26577005, DOI: 10.1016/j.prro.2015.09.007.Peer-Reviewed Original ResearchThe Role of Patient Factors, Cancer Characteristics, and Treatment Patterns in the Cost of Care for Medicare Beneficiaries with Breast Cancer
Xu X, Herrin J, Soulos PR, Saraf A, Roberts KB, Killelea BK, Wang SY, Long JB, Wang R, Ma X, Gross CP. The Role of Patient Factors, Cancer Characteristics, and Treatment Patterns in the Cost of Care for Medicare Beneficiaries with Breast Cancer. Health Services Research 2015, 51: 167-186. PMID: 26119176, PMCID: PMC4722219, DOI: 10.1111/1475-6773.12328.Peer-Reviewed Original ResearchConceptsBreast cancer careHospital referral regionsCancer careMedicare expendituresBreast cancerRadiation therapyTreatment factorsMean Medicare expendituresEnd Results-MedicareSpecific treatment modalitiesContribution of patientCost of careHighest spending quintilePatient factorsTreatment patternsTumor characteristicsCancer characteristicsTreatment modalitiesReferral regionsMedicare beneficiariesQuintilePatientsCancerCareTherapyHistorical trends of radiotherapy use in prevalent malignancies over 38 years in SEER
Yeboa D, Aneja S, Montana G, Roberts K, Yu J. Historical trends of radiotherapy use in prevalent malignancies over 38 years in SEER. Journal Of Radiation Oncology 2015, 4: 11-17. DOI: 10.1007/s13566-015-0182-y.Peer-Reviewed Original ResearchIntensity-modulated radiation therapyProstate cancerRadiation therapyEnd Results (SEER) databaseAmerican Joint CommitteeBreast cancer treatmentUse of RTInitial therapyMethodsThe SurveillanceRT receiptNonmetastatic patientsResults databaseCommon malignancyTherapy utilizationColorectal cancerLung cancerPrevalent malignancyCancer sitesRadiotherapy useHigh incidenceMedical treatmentJoint CommitteeDisease sitesPersistent decreaseTherapy
2014
Examining the Cost-Effectiveness of Radiation Therapy Among Older Women With Favorable-Risk Breast Cancer
Sen S, Wang SY, Soulos PR, Frick KD, Long JB, Roberts KB, Yu JB, Evans SB, Chagpar AB, Gross CP. Examining the Cost-Effectiveness of Radiation Therapy Among Older Women With Favorable-Risk Breast Cancer. Journal Of The National Cancer Institute 2014, 106: dju008. PMID: 24598714, PMCID: PMC3982782, DOI: 10.1093/jnci/dju008.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrachytherapyBreast NeoplasmsComorbidityCost-Benefit AnalysisFemaleHealth ExpendituresHumansLife ExpectancyMedicareNeoplasm Recurrence, LocalNeoplasm StagingQuality of LifeQuality-Adjusted Life YearsRadiotherapy, Intensity-ModulatedRisk AssessmentRisk FactorsSampling StudiesSEER ProgramUnited StatesConceptsExternal beam radiation therapyIncremental cost-effectiveness ratioQuality-adjusted life yearsBreast cancerOlder womenRadiation therapyEnd Results-Medicare databaseRisk breast cancerBeam radiation therapyCost-effectiveness ratioNewer radiation therapy modalitiesQuality of lifeRadiation therapy modalitiesLocal recurrenceTrial criteriaRT modalityTherapy modalitiesLife yearsCancerIncremental costTherapyWomenBaseline stateNew modalityDelayed Cerebral Vasculopathy Following Cranial Radiation Therapy for Pediatric Tumors
Wang C, Roberts KB, Bindra RS, Chiang VL, Yu JB. Delayed Cerebral Vasculopathy Following Cranial Radiation Therapy for Pediatric Tumors. Pediatric Neurology 2014, 50: 549-556. PMID: 24739378, DOI: 10.1016/j.pediatrneurol.2013.09.018.Peer-Reviewed Original ResearchConceptsMedian interval periodIntracerebral hemorrhageMoyamoya syndromeInterval periodCranial radiation therapyRadiation doseIntracerebral hemorrhage casesMoyamoya casesCerebral vasculopathyCerebrovascular injuryMedian agePatient agePediatric patientsDoses of radiationDisease presentationPediatric tumorsRadiation therapyHemorrhage casesHemorrhagePatientsCerebrovasculopathySignificant associationMoyamoyaSyndromeTime of radiation
2013
For-profit hospital ownership status and use of brachytherapy after breast-conserving surgery
Sen S, Soulos PR, Herrin J, Roberts KB, Yu JB, Lesnikoski BA, Ross JS, Krumholz HM, Gross CP. For-profit hospital ownership status and use of brachytherapy after breast-conserving surgery. Surgery 2013, 155: 776-788. PMID: 24787104, PMCID: PMC4008843, DOI: 10.1016/j.surg.2013.12.009.Peer-Reviewed Original ResearchConceptsHospital ownership statusBreast-conserving operationsBreast-conserving surgeryUse of brachytherapyRadiation therapyOperative careBreast cancerMedicare beneficiariesOverall useReceipt of brachytherapyAdjuvant radiation therapyInvasive breast cancerFemale Medicare beneficiariesGreater overall useYears of ageShort life expectancyRetrospective studyRT modalityProfit hospitalsExpensive modalityOlder womenBrachytherapy useBreast brachytherapyHospitalBrachytherapyVariation in Receipt of Radiation Therapy After Breast-conserving Surgery
Feinstein AJ, Soulos PR, Long JB, Herrin J, Roberts KB, Yu JB, Gross CP. Variation in Receipt of Radiation Therapy After Breast-conserving Surgery. Medical Care 2013, 51: 330-338. PMID: 23151590, PMCID: PMC3596448, DOI: 10.1097/mlr.0b013e31827631b0.Peer-Reviewed Original ResearchConceptsUse of RTShort life expectancyRadiation therapyBreast cancerLife expectancyPrimary surgeonStage I breast cancerEarly-stage breast cancerRadiation oncologist densityAdjuvant radiation therapyI breast cancerReceipt of radiationBreast-conserving surgeryImpact of physiciansHierarchical logistic regression modelsLogistic regression modelsLonger life expectancyLE patientsRetrospective cohortLE groupOlder womenPatientsTreatment ratesWomenCancer
2012
Historical Trends in the Use of Radiation Therapy for Pediatric Cancers: 1973-2008
Jairam V, Roberts KB, Yu JB. Historical Trends in the Use of Radiation Therapy for Pediatric Cancers: 1973-2008. International Journal Of Radiation Oncology • Biology • Physics 2012, 85: e151-e155. PMID: 23273995, PMCID: PMC3636568, DOI: 10.1016/j.ijrobp.2012.10.007.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBone NeoplasmsChildChild, PreschoolFemaleHodgkin DiseaseHumansInfantInfant, NewbornLeukemia, Myeloid, AcuteLymphoma, Non-HodgkinMaleNeoplasmsNeuroblastomaOsteosarcomaPrecursor Cell Lymphoblastic Leukemia-LymphomaRadiotherapyRetinoblastomaSEER ProgramSoft Tissue NeoplasmsTime FactorsUnited StatesWilms TumorYoung AdultConceptsUse of RTSoft tissue cancerNon-Hodgkin lymphomaRT useAcute lymphoblastic leukemiaAcute myeloid leukemiaRadiation therapyHodgkin's lymphomaLymphoblastic leukemiaMyeloid leukemiaWilms tumorBrain cancerNational Cancer Institute's SurveillanceExternal beam radiation therapyEnd Results (SEER) databasePercentage of patientsSEER 9 databaseBeam radiation therapyTumor RegistryInitial treatmentResults databaseCombination therapyDiagnosis groupsPediatric cancerJoint cancer