2024
75. Executive Working Memory Intervention Reduces Motor Activity in Adolescents With Attention-Deficit Hyperactivity Disorder
Beatty M, Sullivan A, Anderson J, Choi J, Pearlson G, Hawkins K, Bond D, Stevens M. 75. Executive Working Memory Intervention Reduces Motor Activity in Adolescents With Attention-Deficit Hyperactivity Disorder. Biological Psychiatry 2024, 95: s130. DOI: 10.1016/j.biopsych.2024.02.310.Peer-Reviewed Original Research
2023
Age-related, multivariate associations between white matter microstructure and behavioral performance in three executive function domains
Anderson J, Calhoun V, Pearlson G, Hawkins K, Stevens M. Age-related, multivariate associations between white matter microstructure and behavioral performance in three executive function domains. Developmental Cognitive Neuroscience 2023, 64: 101318. PMID: 37875033, PMCID: PMC10618425, DOI: 10.1016/j.dcn.2023.101318.Peer-Reviewed Original ResearchConceptsExecutive function domainsResponse inhibitionWhite matter microstructureLower response inhibitionStructure-cognition relationshipsEF abilitiesBehavioral performanceCognitive imbalanceNeurocognitive testsFunction domainTest performanceYoung adulthoodFractional anisotropyBrain changesAge 12Young adultsSS performanceWhite matter FA valuesGreater relianceWhite matter changesWhite matter microstructural differencesSubjects ages 12White matter skeletonIndependent componentsMultivariate associations
2022
P436. Multivariate Associations Between White Matter Microstructure Development and Normative Gains in Three Executive Function Domains
Anderson J, Hawkins K, Pearlson G, Stevens M. P436. Multivariate Associations Between White Matter Microstructure Development and Normative Gains in Three Executive Function Domains. Biological Psychiatry 2022, 91: s264. DOI: 10.1016/j.biopsych.2022.02.672.Peer-Reviewed Original Research
2020
Depression predicts cognitive and functional decline one month after coronary artery bypass graft surgery (Neuropsychiatric Outcomes After Heart Surgery study)
Oldham MA, Lin I, Hawkins KA, Li F, Yuh DD, Lee HB. Depression predicts cognitive and functional decline one month after coronary artery bypass graft surgery (Neuropsychiatric Outcomes After Heart Surgery study). International Journal Of Geriatric Psychiatry 2020, 36: 452-460. PMID: 33022808, PMCID: PMC9326959, DOI: 10.1002/gps.5443.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryArtery bypass graft surgeryBypass graft surgeryCABG surgeryGraft surgeryCDR-SBProspective observational cohort studyOlder ageOne monthHamilton Depression Rating ScaleClinical Dementia Rating SumHeart Surgery studyObservational cohort studyDepression Rating ScaleSemi-structured clinical interviewTotal study sampleHopkins Verbal Learning TestPostoperative deliriumPreoperative depressionWord Fluency TestCohort studyVerbal Learning TestNeuropsychiatric outcomesTertiary careFunctional outcomeNeuropsychiatric symptoms and cognitive abilities over the initial quinquennium of Parkinson disease
Weintraub D, Caspell‐Garcia C, Simuni T, Cho HR, Coffey CS, Aarsland D, Alcalay RN, Barrett MJ, Chahine LM, Eberling J, Espay AJ, Hamilton J, Hawkins KA, Leverenz J, Litvan I, Richard I, Rosenthal LS, Siderowf A, York M, Initiative P. Neuropsychiatric symptoms and cognitive abilities over the initial quinquennium of Parkinson disease. Annals Of Clinical And Translational Neurology 2020, 7: 449-461. PMID: 32285645, PMCID: PMC7187707, DOI: 10.1002/acn3.51022.Peer-Reviewed Original ResearchConceptsParkinson's disease participantsNeuropsychiatric symptomsParkinson's diseaseHealthy controlsCognitive impairmentMedication useYear 5Anticholinergic medication useCross-sectional prevalenceParkinson's disease patientsHypnotic useDisease patientsNeuropsychiatric featuresDisease onsetAnnual visitsSymptomsDisorder subtypesAbsolute prevalenceDiseaseTime pointsPrevalenceBaselineImpairmentParticipantsOnset
2019
DEPRESSION PREDICTS DELIRIUM AFTER CORONARY ARTERY BYPASS GRAFT SURGERY INDEPENDENT OF COGNITIVE IMPAIRMENT AND CEREBROVASCULAR DISEASE: AN ANALYSIS OF THE NOAHS STUDY
Lin I, Oldham M, Hawkins K, Scoutt L, Yuh D, Lee H. DEPRESSION PREDICTS DELIRIUM AFTER CORONARY ARTERY BYPASS GRAFT SURGERY INDEPENDENT OF COGNITIVE IMPAIRMENT AND CEREBROVASCULAR DISEASE: AN ANALYSIS OF THE NOAHS STUDY. American Journal Of Geriatric Psychiatry 2019, 27: s160-s161. DOI: 10.1016/j.jagp.2019.01.113.Peer-Reviewed Original ResearchMiddle cerebral arteryMild cognitive impairmentCerebrovascular diseaseCognitive impairmentRisk factorsCoronary artery bypass graft surgeryStenosis severityArtery bypass graft surgeryBilateral middle cerebral arteriesPreoperative cognitive assessmentBypass graft surgeryConfusion Assessment MethodCoronary artery bypassRisk of deliriumDelirium risk factorsObservational cohort studyPostoperative day 2Clinical Dementia RatingPutative risk factorsResults Average ageCI 1.3Preoperative depressionStructured HamiltonStudy psychiatristArtery bypass
2018
Depression Predicts Delirium After Coronary Artery Bypass Graft Surgery Independent of Cognitive Impairment and Cerebrovascular Disease: An Analysis of the Neuropsychiatric Outcomes After Heart Surgery Study
Oldham MA, Hawkins KA, Lin IH, Deng Y, Hao Q, Scoutt LM, Yuh DD, Lee HB. Depression Predicts Delirium After Coronary Artery Bypass Graft Surgery Independent of Cognitive Impairment and Cerebrovascular Disease: An Analysis of the Neuropsychiatric Outcomes After Heart Surgery Study. American Journal Of Geriatric Psychiatry 2018, 27: 476-486. PMID: 30709616, PMCID: PMC6443412, DOI: 10.1016/j.jagp.2018.12.025.Peer-Reviewed Original ResearchConceptsMiddle cerebral arteryMild cognitive impairmentCerebrovascular diseaseCognitive impairmentRisk factorsCoronary artery bypass graft surgeryStenosis severityProspective observational cohort studyArtery bypass graft surgeryBilateral middle cerebral arteriesTertiary care academic hospitalHeart Surgery studyPreoperative cognitive assessmentUndergoing CABG surgeryBypass graft surgeryConfusion Assessment MethodRisk of deliriumDelirium risk factorsObservational cohort studyPostoperative day 2Clinical Dementia RatingDepression InterviewPreoperative depressionStructured HamiltonStudy psychiatristThe effect of age and smoking on the hippocampus and memory in late middle age
Hawkins KA, Emadi N, Pearlson GD, Taylor B, Khadka S, King D, Blank K. The effect of age and smoking on the hippocampus and memory in late middle age. Hippocampus 2018, 28: 846-849. PMID: 30070068, DOI: 10.1002/hipo.23014.Peer-Reviewed Original ResearchConceptsSmoking historyHippocampal volumeHeavy smoking historyVascular risk factorsMiddle-aged subjectsMRI brain scanningAPOE e4 genotypeEffect of ageHeavy smokingHippocampal atrophyAlcohol historyRisk factorsE4 genotypeBrain scanningAPOE e4Neuropsychological assessment batteryHippocampus atrophyFemale subjectsGlobal cognitionMemory disordersData extractionMemory declineAssessment BatteryAgeSmokingCognition among individuals along a spectrum of increased risk for Parkinson’s disease
Chahine LM, Urbe L, Caspell-Garcia C, Aarsland D, Alcalay R, Barone P, Burn D, Espay AJ, Hamilton JL, Hawkins KA, Lasch S, Leverenz JB, Litvan I, Richard I, Siderowf A, Coffey CS, Simuni T, Weintraub D, Initiative T. Cognition among individuals along a spectrum of increased risk for Parkinson’s disease. PLOS ONE 2018, 13: e0201964. PMID: 30125297, PMCID: PMC6101368, DOI: 10.1371/journal.pone.0201964.Peer-Reviewed Original ResearchConceptsParkinson's diseaseIdiopathic REM sleep behavior disorderParkinson's Progression Markers Initiative (PPMI) studyDe novo Parkinson's diseaseREM sleep behavior disorderDopamine transporterNon-motor symptomsNovo Parkinson's diseaseSleep behavior disorderNon-motor featuresSymbol Digit Modalities TestBaseline neuropsychological performanceMontreal Cognitive AssessmentFuture neurodegenerationLewy bodiesInclusion criteriaSpectrum of riskMutation carriersInitiative studyCohortBehavior disorderCognitive functionCognitive test scoresModalities TestNeuropsychological performanceGuanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial
Barcelos NM, Van Ness PH, Wagner AF, MacAvoy MG, Mecca AP, Anderson GM, Trentalange M, Hawkins KA, Sano M, Arnsten AFT, van Dyck CH. Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial. Neurobiology Of Aging 2018, 70: 117-124. PMID: 30007160, PMCID: PMC6503670, DOI: 10.1016/j.neurobiolaging.2018.05.033.Peer-Reviewed Original ResearchConceptsDose of guanfacineQuality of lifeZ-scoreCognitive functionPrefrontal cognitive dysfunctionCommon adverse eventsPrimary outcome measureRandomized clinical trialsGlobal functionOlder participantsHealthy older participantsPrefrontal cognitive functionDry mouthAdverse eventsAgonist guanfacineClinical trialsGuanfacine treatmentCognitive dysfunctionMean changeOutcome measuresPlaceboGuanfacineOlder individualsWeeksDoseRelationship between fMRI response during a nonverbal memory task and marijuana use in college students
Dager AD, Tice MR, Book GA, Tennen H, Raskin SA, Austad CS, Wood RM, Fallahi CR, Hawkins KA, Pearlson GD. Relationship between fMRI response during a nonverbal memory task and marijuana use in college students. Drug And Alcohol Dependence 2018, 188: 71-78. PMID: 29754029, PMCID: PMC6756147, DOI: 10.1016/j.drugalcdep.2018.03.025.Peer-Reviewed Original ResearchConceptsInferior frontal gyrusMJ usersFMRI responsesCollege studentsMemory taskMJ useFunctional magnetic resonance imaging (fMRI) responsesNonverbal memory tasksLower fMRI responseRecognition memoryNeural correlatesMagnetic resonance imaging responseFrontal gyrusVisual encodingRecognition taskOccupational functioningAge 18Memory dysfunctionMarijuana useAcademic performanceLeft hippocampusHippocampal dysfunctionGroup differencesRight hippocampusTaskA New Measure for Neural Compensation Is Positively Correlated With Working Memory and Gait Speed
Ji L, Pearlson GD, Hawkins KA, Steffens DC, Guo H, Wang L. A New Measure for Neural Compensation Is Positively Correlated With Working Memory and Gait Speed. Frontiers In Aging Neuroscience 2018, 10: 71. PMID: 29615893, PMCID: PMC5868123, DOI: 10.3389/fnagi.2018.00071.Peer-Reviewed Original ResearchHigher cognitive reserveCognitive reserveNeural compensationOlder adultsFace-name memory taskHigh cognitive demand tasksCompensatory abilityMemory task performanceTask-activated networksLow cognitive reserveHealthy older adultsSpatial independent component analysisStructural magnetic resonance imaging (MRI) scansNeural resourcesWorking memoryMemory taskCognitive tasksMemory performanceCognitive engagementIndependent component analysisTask performanceNeural activationCognitive functionBrain functionPrior researchLongitudinal Effects of Alcohol Consumption on the Hippocampus and Parahippocampus in College Students
Meda SA, Hawkins KA, Dager AD, Tennen H, Khadka S, Austad CS, Wood RM, Raskin S, Fallahi CR, Pearlson GD. Longitudinal Effects of Alcohol Consumption on the Hippocampus and Parahippocampus in College Students. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 3: 610-617. PMID: 29680476, PMCID: PMC6062479, DOI: 10.1016/j.bpsc.2018.02.006.Peer-Reviewed Original ResearchConceptsAlcohol consumptionAlcohol use indicesHippocampal volume declineBrain magnetic resonanceLongitudinal effectsMemory scoresCalifornia Verbal Learning Test-IIAlcohol-induced memory blackoutsPara-hippocampusHippocampal volumeMemory blackoutsLongitudinal brainVolume declineDrinking indicesLongitudinal pipelinePoorer memory performancePoorer memory scoresHippocampusTest IICross-sectional literatureDrinking-related measuresBrainAlcohol researchMagnetic resonanceScores
2017
Cognition and the course of prodromal Parkinson's disease
Weintraub D, Chahine LM, Hawkins KA, Siderowf A, Eberly S, Oakes D, Seibyl J, Stern MB, Marek K, Jennings D, Investigators T. Cognition and the course of prodromal Parkinson's disease. Movement Disorders 2017, 32: 1640-1645. PMID: 29063713, PMCID: PMC5722226, DOI: 10.1002/mds.27189.Peer-Reviewed Original ResearchConceptsSpeed/attentionCognitive declineProdromal participantsBaseline neuropsychological test performanceExecutive function/Role of cognitionNeuropsychological test performanceFuture cognitive declineBaseline cognitive scoresCognitive domainsGlobal cognitionBaseline cognitionCognitive scoresCognitionTest performanceFuture declinePD-convertersDopamine systemHyposmic individualsProdromal PDLongitudinal changesFunction/ParticipantsDopamine transporter bindingIndividualsHeavy Drinking in College Students Is Associated with Accelerated Gray Matter Volumetric Decline over a 2 Year Period
Meda SA, Dager AD, Hawkins KA, Tennen H, Raskin S, Wood RM, Austad CS, Fallahi CR, Pearlson GD. Heavy Drinking in College Students Is Associated with Accelerated Gray Matter Volumetric Decline over a 2 Year Period. Frontiers In Behavioral Neuroscience 2017, 11: 176. PMID: 29033801, PMCID: PMC5627037, DOI: 10.3389/fnbeh.2017.00176.Peer-Reviewed Original ResearchAbstainers/light drinkersHeavy drinking groupBrain regionsLight drinkersDrinking groupHeavy drinkingSignificant public health issueSignificant GMV decreaseGray matter changesYear followup periodHarmful alcohol usePublic health issueMedial frontal gyrusLongitudinal effectsFollowup periodGMV decreaseMean agePoints 24 monthsBrain MRIMatter changesNeurodevelopmental periodAlcohol consumptionAnterior cingulateTissue lossHeavy drinkersMultiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease
Caspell-Garcia C, Simuni T, Tosun-Turgut D, Wu IW, Zhang Y, Nalls M, Singleton A, Shaw LA, Kang JH, Trojanowski JQ, Siderowf A, Coffey C, Lasch S, Aarsland D, Burn D, Chahine LM, Espay AJ, Foster ED, Hawkins KA, Litvan I, Richard I, Weintraub D, Initiative T. Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease. PLOS ONE 2017, 12: e0175674. PMID: 28520803, PMCID: PMC5435130, DOI: 10.1371/journal.pone.0175674.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersBrain-Derived Neurotrophic FactorCatechol O-MethyltransferaseCognitive DysfunctionDiffusion Tensor ImagingDopamine Plasma Membrane Transport ProteinsFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedParkinson DiseasePolymorphism, Single NucleotideTau ProteinsTomography, Emission-Computed, Single-PhotonConceptsParkinson's diseaseCognitive impairmentDe novo Parkinson's diseaseDopamine transporter single-photon emissionLongitudinal mixed-effects modelsNovo Parkinson's diseaseYears of diseaseIdiopathic Parkinson's diseaseMovement Disorders CenterSingle nucleotide polymorphismsStructural magnetic resonance imagingClinical trial designLongitudinal structural MRIMagnetic resonance imagingSingle photon emissionDevelopment of treatmentsDiffusion tensor imagingBiomarker predictorsPlaque pathologyAmyloid pathologyDopamine deficiencyDopaminergic deficitUnivariate analysisBiomarker changesDisorders CenterLongitudinal influence of alcohol and marijuana use on academic performance in college students
Meda SA, Gueorguieva RV, Pittman B, Rosen RR, Aslanzadeh F, Tennen H, Leen S, Hawkins K, Raskin S, Wood RM, Austad CS, Dager A, Fallahi C, Pearlson GD. Longitudinal influence of alcohol and marijuana use on academic performance in college students. PLOS ONE 2017, 12: e0172213. PMID: 28273162, PMCID: PMC5342177, DOI: 10.1371/journal.pone.0172213.Peer-Reviewed Original ResearchHyperinsulinemia and elevated systolic blood pressure independently predict white matter hyperintensities with associated cognitive decrement in the middle-aged offspring of dementia patients
Hawkins KA, Emadi N, Pearlson GD, Winkler AM, Taylor B, Dulipsingh L, King D, Pittman B, Blank K. Hyperinsulinemia and elevated systolic blood pressure independently predict white matter hyperintensities with associated cognitive decrement in the middle-aged offspring of dementia patients. Metabolic Brain Disease 2017, 32: 849-857. PMID: 28255864, DOI: 10.1007/s11011-017-9980-9.Peer-Reviewed Original ResearchConceptsSystolic blood pressureWMH volumeVascular riskBlood pressurePlasma insulinDementia patientsMRI white matter hyperintensity volumeCognitive declineElevated systolic blood pressureSmall dense LDL-cholesterolWhite matter hyperintensity volumeH systolic BPIndependent risk factorDense LDL cholesterolCognitive decrementsBody mass indexWhite matter damageWhite matter hyperintensitiesApoE ε4 effectMiddle-aged offspringCerebral infarctsLifestyle modificationAggressive treatmentCerebrovascular damageLDL cholesterolComposite impulsivity-related domains in college students
Khadka S, Stevens MC, Aslanzadeh F, Narayanan B, Hawkins KA, Austad CS, Raskin SA, Tennen H, Wood RM, Fallahi C, Potenza MN, Pearlson GD. Composite impulsivity-related domains in college students. Journal Of Psychiatric Research 2017, 90: 118-125. PMID: 28273441, DOI: 10.1016/j.jpsychires.2017.02.016.Peer-Reviewed Original ResearchConceptsConfirmatory factor analysisAttention deficit hyperactivity disorderCollege studentsImpulsivity-related constructsImpulsivity/compulsivityComputerized behavioral measuresDeficit hyperactivity disorderImpulsivity-related behaviorsSelf-report assessmentsSubsequent psychometric analysesHyperactivity disorderBehavioral measuresDistinct constructsImpulsive actionAppetite motivationMultidimensional constructMultiple regression analysisDisorder riskNaturalistic frameworkSimilar analytical approachPsychometric analysisFactor analysisFuture researchIndependent samplesCurrent study
2016
Probing implicit learning in obsessive-compulsive disorder: Moderating role of medication on the weather prediction task
Kelmendi B, Adams T, Jakubovski E, Hawkins KA, Coric V, Pittenger C. Probing implicit learning in obsessive-compulsive disorder: Moderating role of medication on the weather prediction task. Journal Of Obsessive-Compulsive And Related Disorders 2016, 9: 90-95. PMID: 27134820, PMCID: PMC4845758, DOI: 10.1016/j.jocrd.2016.03.003.Peer-Reviewed Original Research