2024
Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions
Knoedler L, Dean J, Diatta F, Thompson N, Knoedler S, Rhys R, Sherwani K, Ettl T, Mayer S, Falkner F, Kilian K, Panayi A, Iske J, Safi A, Tullius S, Haykal S, Pomahac B, Kauke-Navarro M. Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions. Frontiers In Immunology 2024, 15: 1372862. PMID: 38650942, PMCID: PMC11033354, DOI: 10.3389/fimmu.2024.1372862.Peer-Reviewed Original ResearchConceptsRegulatory myeloid cellsSolid organ transplantationVascularized composite allotransplantationMesenchymal stromal cellsT cellsTransplant patientsCellular therapyChimeric antigen receptor T cellsTransplant surgerySide effectsIncreased risk of malignancyProgression to chronic rejectionAcute rejection ratesPerioperative treatment strategiesRegulatory T cellsPromote immune toleranceRisk of malignancySystemic side effectsRelated side effectsCell typesImprove transplant survivalCAR-TCell therapy applicationsImmunosuppressive regimensChronic rejection
2023
Tolerance Induction in Vascularized Composite Allotransplantation—A Brief Review of Preclinical Models
Huelsboemer L, Kauke-Navarro M, Reuter S, Stoegner V, Feldmann J, Hirsch T, Kueckelhaus M, Dermietzel A. Tolerance Induction in Vascularized Composite Allotransplantation—A Brief Review of Preclinical Models. Transplant International 2023, 36: 10955. PMID: 36846605, PMCID: PMC9946984, DOI: 10.3389/ti.2023.10955.Peer-Reviewed Original ResearchConceptsTolerance inductionLong-term effectsAnimal modelsImmune systemDonor-specific toleranceLong-term outcomesRecipient's immune systemPreclinical animal modelsNovel therapeutic strategiesPre-clinical studiesVascularized Composite AllotransplantationChronic rejectionImmunosuppressive protocolsTransplant recipientsAllograft rejectionOrgan dysfunctionPreclinical modelsComposite allograftsTherapeutic strategiesComposite allotransplantationClinical practiceIS protocolClinical translationInductionReview article
2021
A systematic review of immunomodulatory strategies used in skin-containing preclinical vascularized composite allotransplant models
Kauke M, Safi AF, Panayi AC, Palmer WJ, Haug V, Kollar B, Nelms L, Tchiloemba B, Pomahac B. A systematic review of immunomodulatory strategies used in skin-containing preclinical vascularized composite allotransplant models. Journal Of Plastic Reconstructive & Aesthetic Surgery 2021, 75: 586-604. PMID: 34895853, DOI: 10.1016/j.bjps.2021.11.003.Peer-Reviewed Original ResearchConceptsSystematic reviewImmunomodulatory strategiesPreclinical researchAvailable immunosuppressive regimensCurrent standard regimenSystemic side effectsDrug-based approachesMeta-Analyses (PRISMA) guidelinesVCA modelPreferred Reporting ItemsHind limb modelNovel immunomodulatoryRejection episodesAcute rejectionImmunosuppressive regimensStandard regimenAllograft acceptanceAlloimmune responseSuppression therapyImmunomodulation strategiesLimb transplantsPreclinical modelsRat modelHuman trialsTherapeutic approaches
2020
Comparison of Acellular Solutions for Ex-situ Perfusion of Amputated Limbs
Haug V, Kollar B, Endo Y, Kadakia N, Veeramani A, Kauke M, Tchiloemba B, Klasek R, Pomahac B. Comparison of Acellular Solutions for Ex-situ Perfusion of Amputated Limbs. Military Medicine 2020, 185: e2004-e2012. PMID: 33377496, DOI: 10.1093/milmed/usaa160.Peer-Reviewed Original ResearchLocal immunosuppression in vascularized composite allotransplantation (VCA): A systematic review
Safi AF, Kauke M, Nelms L, Palmer WJ, Tchiloemba B, Kollar B, Haug V, Pomahač B. Local immunosuppression in vascularized composite allotransplantation (VCA): A systematic review. Journal Of Plastic Reconstructive & Aesthetic Surgery 2020, 74: 327-335. PMID: 33229219, DOI: 10.1016/j.bjps.2020.10.003.Peer-Reviewed Original ResearchConceptsLocal immunosuppressionSystematic reviewAllograft survivalComposite allotransplantationAllograft survival dataCell-based therapy strategiesImproved allograft survivalMain immunosuppressive agentMeta-Analyses (PRISMA) guidelinesPreclinical animal studiesPreferred Reporting ItemsMalignant side effectsImmunosuppressive agentsPreclinical dataSignificant prolongationRat modelHuman trialsExclusion criteriaImmunosuppressionSide effectsAnimal studiesReporting ItemsPubMed databaseSystemic toxicityTherapy strategies
2019
Vein Graft Interposition: A Training Model Using Gradually Thawed Cryopreserved Vessels.
Safi AF, Safi S, Tayeh M, Gojowy D, Timmer M, Goldbrunner R, Kauke M. Vein Graft Interposition: A Training Model Using Gradually Thawed Cryopreserved Vessels. Journal Of Craniofacial Surgery 2019, 30: e213-e216. PMID: 30845093, DOI: 10.1097/scs.0000000000005197.Peer-Reviewed Original Research
2018
Epineurial Nerve Coaptation
Safi AF, Safi S, Timmer M, Goldbrunner R, Kauke M. Epineurial Nerve Coaptation. Journal Of Craniofacial Surgery 2018, 29: e708-e712. PMID: 30192297, DOI: 10.1097/scs.0000000000004998.Peer-Reviewed Original ResearchA novel microsurgical anastomosis training model using gradually thawed cryopreserved microvessels of rat cadavers
Safi AF, Safi S, Tayeh M, Timmer M, Goldbrunner R, Kauke M. A novel microsurgical anastomosis training model using gradually thawed cryopreserved microvessels of rat cadavers. Journal Of Cranio-Maxillofacial Surgery 2018, 46: 1126-1131. PMID: 29802058, DOI: 10.1016/j.jcms.2018.05.018.Peer-Reviewed Original ResearchConceptsCommon carotid arteryExternal jugular veinFemoral vesselsVenous anastomosisLocal ethics committeePatency failurePatency ratesFemoral arteryVein anastomosisCarotid arteryJugular veinMicrovessel anastomosesNeck anatomyCadaveric studyAnastomosisPrior microsurgical experienceSurgical anatomyMicrosurgical experienceAnatomical dissectionEthics CommitteeOperation timeNovel training modelAverage timeArteryCadaveric vessels