Featured Publications
Cytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study
Kauke-Navarro M, Panayi AC, Formica R, Marty F, Parikh N, Foroutanjazi S, Safi AF, Mardini S, Razonable RR, Morelon E, Gelb B, Rodriguez E, Lassus P, Pomahac B. Cytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study. Transplantation 2022, 106: 2031-2043. PMID: 35389381, DOI: 10.1097/tp.0000000000004132.Peer-Reviewed Original ResearchMeSH KeywordsAntiviral AgentsCytomegalovirusCytomegalovirus InfectionsHumansRetrospective StudiesValganciclovirVascularized Composite AllotransplantationViremiaConceptsRetrospective cohort studyAntiviral prophylaxisCohort studyComposite allotransplantationInternational multicenter retrospective cohort studyMulticenter retrospective cohort studyCMV-related complicationsFirst year posttransplantHigh-risk transplantsMore rejection episodesHigh-risk groupFacial Vascularized Composite AllotransplantationAllograft-related complicationsVascularized Composite AllotransplantationPaucity of dataAllograft lossCMV diseaseCMV viremiaCytomegalovirus serostatusR serostatusRejection episodesCMV infectionPrompt treatmentActive surveillancePatients
2024
Risk of Postoperative Complications After Total Hip and Total Knee Arthroplasty in Behcet Syndrome Patients
Ratnasamy P, Diatta F, Allam O, Kauke-Navarro M, Grauer J. Risk of Postoperative Complications After Total Hip and Total Knee Arthroplasty in Behcet Syndrome Patients. JAAOS Global Research And Reviews 2024, 8: e24.00040. PMID: 39392934, PMCID: PMC11469891, DOI: 10.5435/jaaosglobal-d-24-00040.Peer-Reviewed Original ResearchConceptsBehcet's syndromeAdverse eventsTotal knee arthroplastyMultivariate analysisRevision surgeryRisk of postoperative complicationsRisk of perioperative adverse eventsTotal hip arthroplastyLog-rank testElixhauser Comorbidity Index scoreRetrospective cohort studyMultisystem autoimmune disorderPostoperative adverse eventsPerioperative adverse eventsComorbidity Index scoreNational administrative databaseKnee arthroplastyTotal knee arthroplasty patientsPostoperative complicationsNo significant differencePatient ageAutoimmune disordersPerioperative managementSyndrome patientsCohort studyIncreased Risk of 90-Day Complications in Patients With Fibromyalgia Undergoing Total Shoulder Arthroplasty
Sanchez J, Rancu A, Diatta F, Jonnalagadda A, Dhodapkar M, Knoedler L, Kauke-Navarro M, Grauer J. Increased Risk of 90-Day Complications in Patients With Fibromyalgia Undergoing Total Shoulder Arthroplasty. JAAOS Global Research And Reviews 2024, 8: e24.00102. PMID: 38722914, PMCID: PMC11081627, DOI: 10.5435/jaaosglobal-d-24-00102.Peer-Reviewed Original ResearchMeSH KeywordsAgedArthroplasty, Replacement, ShoulderFemaleFibromyalgiaHumansMaleMiddle AgedOsteoarthritisPostoperative ComplicationsRetrospective StudiesRisk FactorsConceptsRevision-free survivalDay of surgeryAdverse eventsTSA patientsIncreased riskMultivariate analysisOdds ratioIncreased risk of adverse eventsUrinary tract infectionLog-rank testRisk of adverse eventsSurgical site infectionSevere adverse eventsEffective treatment optionAcute kidney injuryDeep vein thrombosisMinor adverse eventsNon-fibromyalgia patientsEnd-stage glenohumeral osteoarthritisAssociation of fibromyalgiaIncreased odds ratioTotal shoulder arthroplastyShoulder infectionPulmonary embolismTract infections
2023
Surgical management of breast fat necrosis: Multi-institutional data analysis of early outcomes and risk factors for complications
Knoedler S, Knoedler L, Patel H, Diatta F, Camacho J, Sofo G, Perozzo F, Evans B, Mookerjee V, Ayyala H, Pomahac B, Kauke-Navarro M. Surgical management of breast fat necrosis: Multi-institutional data analysis of early outcomes and risk factors for complications. Journal Of Plastic Reconstructive & Aesthetic Surgery 2023, 88: 292-295. PMID: 38029475, DOI: 10.1016/j.bjps.2023.11.015.Peer-Reviewed Original ResearchConceptsBreast fat necrosisChronic heart failureRisk factorsAdverse eventsHeart failureFemale patientsSurgical managementFat necrosisNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramHigher wound classPostoperative adverse eventsNon-cancerous conditionsOutcomes of interestQuality Improvement ProgramMajority of casesPerioperative algorithmWound classComplication occurrenceComplication ratePostoperative outcomesSurgical complicationsMedical complicationsSurgical treatmentMultivariable analysisCorrelation between facial vascularized composite allotransplantation rejection and laboratory markers: Insights from a retrospective study of eight patients
Kauke-Navarro M, Knoedler S, Panayi A, Knoedler L, Haller B, Parikh N, Huelsboemer L, Stoegner V, Kiefer J, Eisenhardt S, Azzi J, Pomahac B. Correlation between facial vascularized composite allotransplantation rejection and laboratory markers: Insights from a retrospective study of eight patients. Journal Of Plastic Reconstructive & Aesthetic Surgery 2023, 83: 155-164. PMID: 37276734, DOI: 10.1016/j.bjps.2023.04.050.Peer-Reviewed Original Research
2022
Perioperative Outcomes and Risk Profile of 4730 Cosmetic Breast Surgery Cases in Academic Institutions: An ACS-NSQIP Analysis
Knoedler S, Kauke-Navarro M, Haug V, Broer P, Pomahac B, Knoedler L, Panayi A. Perioperative Outcomes and Risk Profile of 4730 Cosmetic Breast Surgery Cases in Academic Institutions: An ACS-NSQIP Analysis. Aesthetic Surgery Journal 2022, 43: 433-451. PMID: 36472232, DOI: 10.1093/asj/sjac320.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseCosmetic breast surgeryObstructive pulmonary diseaseRisk factorsSurgical complicationsPulmonary diseaseSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseMulti-institutional national databaseMultiple proceduresQuality Improvement Program databaseImprovement Program databaseIndependent risk factorCongestive heart failurePositive safety profileObesity class 1ACS-NSQIP AnalysisAnesthesiology scoreBreast surgery casesPerioperative outcomesPerioperative protocolPostoperative outcomesClinical patternHeart failureFemale patientsThe modified 5-item frailty index is a predictor of perioperative risk in breast reconstruction: An analysis of 40,415 cases
Panayi AC, Foroutanjazi S, Parikh N, Haug V, Kauke-Navarro M, Diehm YF, Pomahac B. The modified 5-item frailty index is a predictor of perioperative risk in breast reconstruction: An analysis of 40,415 cases. Journal Of Plastic Reconstructive & Aesthetic Surgery 2022, 75: 2941-2954. PMID: 35599223, DOI: 10.1016/j.bjps.2022.04.035.Peer-Reviewed Original ResearchMeSH KeywordsAgedFrailtyHumansMammaplastyPatient ReadmissionPostoperative ComplicationsRetrospective StudiesRisk AssessmentRisk FactorsConceptsImplant-based reconstructionBreast reconstructionMFI-5Unplanned readmissionPostoperative outcomesSurgical complicationsMedical complicationsMFI scoreRisk predictorsSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseBreast reconstruction patientsFrailty index-5Powerful risk predictorImprovement Program databasePreoperative risk stratificationStrong risk predictorAutologous breast reconstructionAdverse surgical outcomesType of reconstructionHigh rateFrail patientsHospital stayPerioperative riskRacial disparities in short-term outcomes after breast reduction surgery–A National Surgical Quality Improvement Project Analysis with 23,268 patients using Propensity Score Matching
Haug V, Kadakia N, Wang AT, Dorante MI, Panayi AC, Kauke-Navarro M, Hundeshagen G, Diehm YF, Fischer S, Hirche C, Kneser U, Pomahac B. Racial disparities in short-term outcomes after breast reduction surgery–A National Surgical Quality Improvement Project Analysis with 23,268 patients using Propensity Score Matching. Journal Of Plastic Reconstructive & Aesthetic Surgery 2022, 75: 1849-1857. PMID: 35131191, DOI: 10.1016/j.bjps.2022.01.001.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesEthnicityHumansMammaplastyPostoperative ComplicationsPropensity ScoreQuality ImprovementRetrospective StudiesConceptsBreast reduction surgeryPropensity scoreSurgical complicationsPreoperative variablesReduction surgerySurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseMajor surgical complicationsImprovement Program databaseMinor surgical complicationsShort-term outcomesNon-white patientsNumber of patientsEthnic health inequalitiesNon-white cohortsPostoperative outcomesDiabetes mellitusMajor complicationsMedical complicationsSurgical outcomesPatient ethnicityProgram databaseInclusion criteriaSurgical care
2021
The Impact of Metabolic Syndrome on Microvascular Head and Neck Reconstruction: An ACS-NSQIP data analysis
Panayi AC, Haug V, Kauke-Navarro M, Diehm YF, Pomahac B. The Impact of Metabolic Syndrome on Microvascular Head and Neck Reconstruction: An ACS-NSQIP data analysis. Journal Of Plastic Reconstructive & Aesthetic Surgery 2021, 75: 1360-1371. PMID: 34955390, DOI: 10.1016/j.bjps.2021.11.074.Peer-Reviewed Original ResearchConceptsSuperficial incisional infectionSeptic shockMedical complicationsNeck microvascular reconstructionMetS patientsMicrovascular reconstructionIncisional infectionPostoperative outcomesMetS groupMetabolic syndromeSurgical outcomesHigh rateOrgan space infectionPostoperative medical complicationsOccurrence of sepsisAverage operative timeImpact of MetSMicrovascular flap reconstructionPoor surgical outcomesSkilled care facilitySite of surgeryFree skin flapsType of flapTerms of demographicsHospital stayDonor and Recipient Matching in Facial Vascularized Composite Allotransplantation: A Closer Look at the Donor Pool
Kauke M, Haug V, Obed D, Diehm Y, Tchiloemba B, Safi AF, Pomahac B. Donor and Recipient Matching in Facial Vascularized Composite Allotransplantation: A Closer Look at the Donor Pool. Plastic & Reconstructive Surgery 2021, 148: 194-202. PMID: 34181616, DOI: 10.1097/prs.0000000000008094.Peer-Reviewed Original ResearchConceptsDonor poolHepatitis CUnited NetworkPotential donorsEpstein-Barr virus seropositivityCytomegalovirus-seropositive donorsUnderrepresented patient groupsOrgan Sharing databaseFacial Vascularized Composite AllotransplantationHigh-risk characteristicsVascularized Composite AllotransplantationActual wait timesAllotransplant patientsSeronegative patientsSeropositive donorsMost patientsAllotransplant recipientsPatient characteristicsRecipient matchingSharing databasePositive donorsPatient groupVirus seropositivityOrgan SharingOrgan donorsThree-Dimensional Osteosynthesis Plates for the Surgical Treatment of Mandibular Fractures
Khalil S, Khamis H, Kauke M, Iizuka T, Safi AF. Three-Dimensional Osteosynthesis Plates for the Surgical Treatment of Mandibular Fractures. Journal Of Craniofacial Surgery 2021, 32: e728-e735. PMID: 34172684, DOI: 10.1097/scs.0000000000007709.Peer-Reviewed Original ResearchMeSH KeywordsBone PlatesFracture Fixation, InternalHumansMandibular FracturesProspective StudiesRetrospective StudiesTreatment OutcomeConceptsAdditional surgical interventionMandibular fracturesPostoperative complicationsMajor complicationsRetrospective studySurgical interventionSystematic reviewPlate fractureAge of patientsEffective treatment modalityNumber of patientsRisk of biasComprehensive electronic searchCochrane HandbookSurgical treatmentClinical outcomesStability of osteosynthesisProspective studyWound dehiscenceOutcome parametersTreatment modalitiesMandible fracturesLower incidenceHigh riskFracture classificationDynamic Maxillary Sinus Changes of Facial Vascularized Composite Allotransplants.
Kauke M, Safi AF, Palmer WJ, Kollar B, Nelms L, Tchiloemba B, Haug V, Pomahac B. Dynamic Maxillary Sinus Changes of Facial Vascularized Composite Allotransplants. Plastic & Reconstructive Surgery 2021, 147: 722-727. PMID: 33620943, DOI: 10.1097/prs.0000000000007673.Peer-Reviewed Original ResearchConceptsMaxillary sinusFace transplant recipientsTransplant recipientsAllograft rejectionTissue changesBiopsy-proven allograft rejectionDiagnosis of rejectionMedication side effectsMaxillary sinus mucosaIndividualized treatment strategiesTissue allograft rejectionVascularized composite allotransplantsFace transplant patientsDynamic tissue changesRadiologic biomarkersRejection gradeTransplant patientsMucosal swellingSinonasal tractSinus changesSinus mucosaClinical managementTomographic scanPathologic changesTreatment strategies
2020
Pathologies of oral and sinonasal mucosa following facial vascularized composite allotransplantation
Kauke-Navarro M, Tchiloemba B, Haug V, Kollar B, Diehm Y, Safi AF, Treister NS, Annino DJ, Marty FM, Lian CG, Murphy GF, Pomahac B. Pathologies of oral and sinonasal mucosa following facial vascularized composite allotransplantation. Journal Of Plastic Reconstructive & Aesthetic Surgery 2020, 74: 1562-1571. PMID: 33376080, DOI: 10.1016/j.bjps.2020.11.028.Peer-Reviewed Original ResearchConceptsNasal mucous membraneMucous membranesMucosal inflammationMucosal lesionsBanff gradeInflammatory mucosal lesionsUlceration/erosionRetrospective cohort studyClinico-pathologic variablesMucosal rejectionCohort studyCutaneous changesIndependent predictorsMucosal assessmentOral lesionsSkin rejectionSinonasal mucosaCommon lesionsMedical recordsUnivariate analysisCutaneous pathologyBuccal mucosaNasal vestibuleOral cavityComposite allotransplantation
2019
MMP3 Is a Non-invasive Biomarker of Rejection in Skin-Bearing Vascularized Composite Allotransplantation: A Multicenter Validation Study
Kollar B, Uffing A, Borges TJ, Shubin AV, Aoyama BT, Dagot C, Haug V, Kauke M, Safi AF, Talbot SG, Morelon E, Dakpe S, Pomahac B, Riella LV. MMP3 Is a Non-invasive Biomarker of Rejection in Skin-Bearing Vascularized Composite Allotransplantation: A Multicenter Validation Study. Frontiers In Immunology 2019, 10: 2771. PMID: 31849957, PMCID: PMC6897344, DOI: 10.3389/fimmu.2019.02771.Peer-Reviewed Original ResearchConceptsMatrix metalloproteinase-3MMP3 levelsNon-invasive biomarkersTransplant recipientsAcute rejectionHealthy controlsComposite allotransplantationRejection stateCandidate non-invasive biomarkersUpper extremity transplant recipientsSerum samplesAntibody-mediated rejectionKidney transplant recipientsSeverity of rejectionPre-transplant levelsAutoimmune skin diseaseLongitudinal serum samplesSkin disease patientsVascularized Composite AllotransplantationMulticenter validation studyFace transplant recipientsLarger validation studiesClinical VCARejection episodesVCA patientsDoes Meningioma Volume Correlate With Clinical Disease Manifestation Irrespective of Histopathologic Tumor Grade?
Kauke M, Safi AF, Stavrinou P, Krischek B, Goldbrunner R, Timmer M. Does Meningioma Volume Correlate With Clinical Disease Manifestation Irrespective of Histopathologic Tumor Grade? Journal Of Craniofacial Surgery 2019, 30: e799-e802. PMID: 31633669, DOI: 10.1097/scs.0000000000005845.Peer-Reviewed Original ResearchConceptsHigher tumor volumeTumor gradeTumor volumeClinical disease manifestationsHistopathological tumor gradeHistopathologic tumor gradeRadiological biomarkersClinical symptomsCystic degenerationTumor locationDisease manifestationsPeritumoral edemaTumor aggressivenessMeningioma volumeVolume correlateVolumetric analysisMass effectSemiautomatic image segmentationITK-SNAPThe Importance of Serological Procalcitonin Levels After Autologous Microsurgical Transplantation
Safi AF, Schröder K, Kauke M, Safi S, Zöller JE, Zinser M. The Importance of Serological Procalcitonin Levels After Autologous Microsurgical Transplantation. Journal Of Craniofacial Surgery 2019, Publish Ahead of Print: &na;. PMID: 30817542, DOI: 10.1097/scs.0000000000005431.Peer-Reviewed Original ResearchMeSH KeywordsHumansMicrosurgeryPlastic Surgery ProceduresPostoperative ComplicationsProcalcitoninRetrospective StudiesTransplantation, AutologousVascular GraftingConceptsSoft tissue defectsPCT levelsProcalcitonin levelsSystemic inflammationMicrosurgical interventionTissue defectsPCT cutoff levelPerioperative systemic inflammationHigh mortality rateMicrovascular transplantsMicrovascular transplantationSevere complicationsSevere morbidityRetrospective studySurgical interventionTransplant lossMicrosurgical transplantationTreatment strategiesInclusion criteriaCutoff levelMortality ratePatientsReconstructive surgeonPathological levelsDetectable increase
2018
Image segmentation-based volume approximation—volume as a factor in the clinical management of osteolytic jaw lesions
Kauke M, Safi AF, Grandoch A, Nickenig HJ, Zöller J, Kreppel M. Image segmentation-based volume approximation—volume as a factor in the clinical management of osteolytic jaw lesions. Dentomaxillofacial Radiology 2018, 48: 20180113. PMID: 30216090, PMCID: PMC6398913, DOI: 10.1259/dmfr.20180113.Peer-Reviewed Original ResearchEvaluation of Fronto-Orbital Advancement Using Titanium-Based Internal Fixation for Corrective Pediatric Craniofacial Surgery
Kreppel M, Kauke M, Grandoch A, Safi AF, Nickenig HJ, Zöller J. Evaluation of Fronto-Orbital Advancement Using Titanium-Based Internal Fixation for Corrective Pediatric Craniofacial Surgery. Journal Of Craniofacial Surgery 2018, 29: 1542-1545. PMID: 29916974, DOI: 10.1097/scs.0000000000004689.Peer-Reviewed Original ResearchConceptsFronto-orbital advancementPediatric craniofacial surgerySecondary surgeryEsthetic outcomeFixation systemRigid fixation systemsRate of complicationsCraniofacial surgeryInternal rigid fixationPlate fixation systemComplication rateSurgical drainsInternal fixationMean durationSecond HospitalSecondary interventionsMedical recordsInternal fixation systemWhitaker scoreRigid fixationSurgeryPatientsBone fragmentsComplicationsCranial vaultClinical evaluation of non-syndromic scaphocephaly surgically corrected with the procedure of total vertex craniectomy
Kreppel M, Kauke M, Safi AF, Grandoch A, Pocek-Behn N, Nickenig HJ, Zöller J. Clinical evaluation of non-syndromic scaphocephaly surgically corrected with the procedure of total vertex craniectomy. Journal Of Cranio-Maxillofacial Surgery 2018, 46: 1465-1469. PMID: 29960814, DOI: 10.1016/j.jcms.2018.05.057.Peer-Reviewed Original ResearchConceptsTime of surgeryStandardized operative techniqueSingle-surgeon approachMonths of ageReoperation rateMajor complicationsCorrective surgeryMean durationClinical evaluationSurgical correctionSurgical methodsOperative techniqueWhitaker scoreRetrospective evaluationSurgeon's approachCraniectomyAesthetic outcomeYoung individualsMonthsPatientsSurgeryScaphocephalyCategory IVCategory IOutcomesDoes volumetric measurement of cervical lymph nodes serve as an imaging biomarker for locoregional recurrence of oral squamous cell carcinoma?
Safi AF, Kauke M, Jung H, Timmer M, Borggrefe J, Persigehl T, Nickenig HJ, Zinser M, Maintz D, Kreppel M, Zöller J. Does volumetric measurement of cervical lymph nodes serve as an imaging biomarker for locoregional recurrence of oral squamous cell carcinoma? Journal Of Cranio-Maxillofacial Surgery 2018, 46: 1013-1018. PMID: 29709330, DOI: 10.1016/j.jcms.2018.04.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkersCarcinoma, Squamous CellChemoradiotherapyFemaleHumansLymph NodesLymphatic MetastasisMaleMicrosurgeryMiddle AgedMouth NeoplasmsMultivariate AnalysisNeckNeck DissectionNeoadjuvant TherapyNeoplasm Recurrence, LocalPrognosisRetrospective StudiesRisk FactorsTomography, X-Ray ComputedConceptsOral squamous cell carcinomaLymph node volumeSquamous cell carcinomaLocoregional recurrenceN classificationCell carcinomaNode volumeInclusion criteriaComputed tomographyTreatment-naive oral squamous cell carcinomaIpsilateral lymph node metastasisBetter risk stratification toolsComprehensive neck dissectionPathological N classificationCervical lymph nodesNegative resection marginsRetrospective chart reviewRisk stratification toolLymph node metastasisPreoperative computed tomographyVolumetric measurementsT4b classificationUnresectable diseaseLocoregional failureNeoadjuvant chemoradiotherapy