2024
Cellular therapeutics and immunotherapies in wound healing – on the pulse of time?
Huelsboemer L, Knoedler L, Kochen A, Yu C, Hosseini H, Hollmann K, Choi A, Stögner V, Knoedler S, Hsia H, Pomahac B, Kauke-Navarro M. Cellular therapeutics and immunotherapies in wound healing – on the pulse of time? Military Medical Research 2024, 11: 23. PMID: 38637905, PMCID: PMC11025282, DOI: 10.1186/s40779-024-00528-5.Peer-Reviewed Original ResearchConceptsStandard of careChronic wound healing disordersLocal wound irrigationWound healingChronic inflammatory microenvironmentFree flap techniqueWound healing disordersChronic woundsGenetic risk profilesPhysiological wound healingAdequate blood supplySurgical debridementFlap techniqueCellular therapyCurrent therapiesHealing disordersInflammatory microenvironmentWound irrigationNon-healing woundsCellular therapeuticsGeneral anesthesiaFormation of biofilmsWound debridementSkin graftsImmunotherapy
2023
Regulatory T cells in skin regeneration and wound healing
Knoedler S, Knoedler L, Kauke-Navarro M, Rinkevich Y, Hundeshagen G, Harhaus L, Kneser U, Pomahac B, Orgill D, Panayi A. Regulatory T cells in skin regeneration and wound healing. Military Medical Research 2023, 10: 49. PMID: 37867188, PMCID: PMC10591349, DOI: 10.1186/s40779-023-00484-6.Peer-Reviewed Original ResearchConceptsRegulatory T cellsT cellsRole of TregsIntegumentary systemNew treatment modalitiesTissue-resident cellsSubsequent wound healing processCutaneous wound healingExcessive inflammationImmune homeostasisTreatment modalitiesImmune cellsSkin adnexaWound healing processImmune responseTregsHealing processWound repairWound healingHealingEpidermal integrityCellsCollateral damageAdnexaInflammationFibroblasts – the cellular choreographers of wound healing
Knoedler S, Broichhausen S, Guo R, Dai R, Knoedler L, Kauke-Navarro M, Diatta F, Pomahac B, Machens H, Jiang D, Rinkevich Y. Fibroblasts – the cellular choreographers of wound healing. Frontiers In Immunology 2023, 14: 1233800. PMID: 37646029, PMCID: PMC10461395, DOI: 10.3389/fimmu.2023.1233800.Peer-Reviewed Original ResearchConceptsFibroblast diversityInnate immune cellsNovel treatment modalitiesWound healing functionsFascial connective tissueRole of fibroblastsTreatment modalitiesImmune cellsWound repairScar tissueDiversityFibroblastsConnective tissueHealing processWound healingComprehensive understandingMachineryTissueHealing functionCascade