2023
Cellular activation pathways and interaction networks in vascularized composite allotransplantation
Knoedler L, Knoedler S, Panayi A, Lee C, Sadigh S, Huelsboemer L, Stoegner V, Schroeter A, Kern B, Mookerjee V, Lian C, Tullius S, Murphy G, Pomahac B, Kauke-Navarro M. Cellular activation pathways and interaction networks in vascularized composite allotransplantation. Frontiers In Immunology 2023, 14: 1179355. PMID: 37266446, PMCID: PMC10230044, DOI: 10.3389/fimmu.2023.1179355.Peer-Reviewed Original ResearchConceptsVascularized Composite AllotransplantationComposite allotransplantationRecipient-derived lymphocytesTreatment of patientsCellular activation pathwaysMultidrug immunosuppressionVCA graftsVCA patientsVCA rejectionGraft rejectionDevastating injuriesClinical managementNovel therapiesReconstructive surgeryLimb lossRejection responseFacial disfigurementAllotransplantationPatientsGraftActivation pathwayTissue cellsDifferent cell typesTissue typesCell types
2019
MMP3 Is a Non-invasive Biomarker of Rejection in Skin-Bearing Vascularized Composite Allotransplantation: A Multicenter Validation Study
Kollar B, Uffing A, Borges TJ, Shubin AV, Aoyama BT, Dagot C, Haug V, Kauke M, Safi AF, Talbot SG, Morelon E, Dakpe S, Pomahac B, Riella LV. MMP3 Is a Non-invasive Biomarker of Rejection in Skin-Bearing Vascularized Composite Allotransplantation: A Multicenter Validation Study. Frontiers In Immunology 2019, 10: 2771. PMID: 31849957, PMCID: PMC6897344, DOI: 10.3389/fimmu.2019.02771.Peer-Reviewed Original ResearchConceptsMatrix metalloproteinase-3MMP3 levelsNon-invasive biomarkersTransplant recipientsAcute rejectionHealthy controlsComposite allotransplantationRejection stateCandidate non-invasive biomarkersUpper extremity transplant recipientsSerum samplesAntibody-mediated rejectionKidney transplant recipientsSeverity of rejectionPre-transplant levelsAutoimmune skin diseaseLongitudinal serum samplesSkin disease patientsVascularized Composite AllotransplantationMulticenter validation studyFace transplant recipientsLarger validation studiesClinical VCARejection episodesVCA patients