Featured Publications
Cytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study
Kauke-Navarro M, Panayi AC, Formica R, Marty F, Parikh N, Foroutanjazi S, Safi AF, Mardini S, Razonable RR, Morelon E, Gelb B, Rodriguez E, Lassus P, Pomahac B. Cytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study. Transplantation 2022, 106: 2031-2043. PMID: 35389381, DOI: 10.1097/tp.0000000000004132.Peer-Reviewed Original ResearchConceptsRetrospective cohort studyAntiviral prophylaxisCohort studyComposite allotransplantationInternational multicenter retrospective cohort studyMulticenter retrospective cohort studyCMV-related complicationsFirst year posttransplantHigh-risk transplantsMore rejection episodesHigh-risk groupFacial Vascularized Composite AllotransplantationAllograft-related complicationsVascularized Composite AllotransplantationPaucity of dataAllograft lossCMV diseaseCMV viremiaCytomegalovirus serostatusR serostatusRejection episodesCMV infectionPrompt treatmentActive surveillancePatients
2024
From Novel Facial Measurements to Facial Implantology – A systematic review
Baecher H, Scheiflinger A, Remy K, Straub N, Maheta B, Sherwani K, Deniz C, Knoedler S, Safi A, Kauke-Navarro M, Heiland M, Knoedler L. From Novel Facial Measurements to Facial Implantology – A systematic review. JPRAS Open 2024 DOI: 10.1016/j.jpra.2024.10.005.Peer-Reviewed Original ResearchFacial implantsFacial measurementsOptimal implant planningSurgical site infectionStandard facial measurementsImplant planningSite infectionAesthetic outcomesBone augmentationPotential complicationsWeb of ScienceNasal regionPatient satisfactionPorous polyethyleneComprehensive searchSystematic reviewComplicationsPatientsImplantationOutcomesCentral databaseFacial analysisReviewImplantologyMandibularThe impact of age on outcomes after breast reduction surgery – A multi-institutional data analysis of 40,958 cases
Knoedler S, Perozzo F, Jiang J, Kosyk M, Alfertshofer M, Schenck T, Kern B, Sofo G, Knoedler L, Panayi A, Pomahac B, Kauke-Navarro M, Kim B. The impact of age on outcomes after breast reduction surgery – A multi-institutional data analysis of 40,958 cases. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024, 98: 318-330. PMID: 39321535, DOI: 10.1016/j.bjps.2024.09.027.Peer-Reviewed Original ResearchReduction mammoplastyFemale patientsMedical complicationsImpact of ageAmerican College of Surgeons National Surgical Quality Improvement ProgramSurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramPatients aged <Patients aged >Breast reduction surgeryAdult female patientsQuality Improvement ProgramPostoperative morbiditySurgical complicationsPostoperative outcomesPatient ageReduction surgeryDeterminants of riskMultivariate analysisAmerican CollegeComplicationsLow riskPatientsMammoplastyAdvancements in facial implantology: a review of hydroxyapatite applications and outcomes
Kauke-Navarro M, Knoedler L, Knoedler S, Safi A. Advancements in facial implantology: a review of hydroxyapatite applications and outcomes. Frontiers In Surgery 2024, 11: 1409733. PMID: 39092153, PMCID: PMC11291363, DOI: 10.3389/fsurg.2024.1409733.Peer-Reviewed Original ResearchFacial skeletal reconstructionLong-term safetySkeletal reconstructionFacial balanceTumor resectionCraniofacial surgeryAesthetic resultsFacial implantsReconstructive surgeryWeb of Science databasesInclusion criteriaPatient outcomesPatient satisfactionPatientsImplant integrationSystematic reviewSurgeryFacial reconstructionHAP implantsOutcomesGoogle ScholarScience databasesEfficacyHydroxyapatite applicationImplantationEarly outcomes and risk factors for complications after facial alloplastic implant surgery: An ACS-NSQIP study
Kauke-Navarro M, Knoedler L, Deniz C, Knoedler S, Safi A. Early outcomes and risk factors for complications after facial alloplastic implant surgery: An ACS-NSQIP study. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024, 90: 209-214. PMID: 38387417, DOI: 10.1016/j.bjps.2024.02.021.Peer-Reviewed Original ResearchACS-NSQIPAlloplastic augmentationACS-NSQIP databaseAlloplastic facial implantsHigher complication ratesComplex craniofacial disordersComplication rateImplant surgeryMandibular regionCraniofacial disordersEarly outcomesFacial implantsActive smokersMandibular augmentationSurgeryFacial surgeryComplicationsRisk factorsPatientsStudy populationCPT codesMalarInpatient stayComorbidity ratesZygoma
2023
The significance of timing in breast reconstruction after mastectomy: An ACS-NSQIP analysis
Knoedler S, Kauke-Navarro M, Knoedler L, Friedrich S, Ayyala H, Haug V, Didzun O, Hundeshagen G, Bigdeli A, Kneser U, Machens H, Pomahac B, Orgill D, Broer P, Panayi A. The significance of timing in breast reconstruction after mastectomy: An ACS-NSQIP analysis. Journal Of Plastic Reconstructive & Aesthetic Surgery 2023, 89: 40-50. PMID: 38134626, DOI: 10.1016/j.bjps.2023.11.049.Peer-Reviewed Original ResearchImmediate BRTime pointsACS-NSQIP databaseLow complication rateACS-NSQIP AnalysisBreast cancer patientsBreast reconstruction optionsAutologous cohortsComplication rateSignificance of timingFemale patientsMedical complicationsMultivariable analysisMore complicationsPatient eligibilityCancer patientsBreast reconstructionOncological purposesPatientsComplicationsReconstruction optionsPropensity scoreCase workupMastectomyEligibilityApplication possibilities of artificial intelligence in facial vascularized composite allotransplantation—a narrative review
Knoedler L, Knoedler S, Allam O, Remy K, Miragall M, Safi A, Alfertshofer M, Pomahac B, Kauke-Navarro M. Application possibilities of artificial intelligence in facial vascularized composite allotransplantation—a narrative review. Frontiers In Surgery 2023, 10: 1266399. PMID: 38026484, PMCID: PMC10646214, DOI: 10.3389/fsurg.2023.1266399.Peer-Reviewed Original ResearchComposite allotransplantationLong-term outcomesFacial trauma patientsSevere facial disfigurementRejection episodesSurgical treatmentTrauma patientsMalignancy screeningReconstructive surgeryClinical challengeFacial traumaPaucity of studiesReconstructive strategiesNarrative reviewPatientsFacial disfigurementAllotransplantationFuture studiesSurgeryDiagnosisTraumaDisfigurementUnderstanding the Drivers of Cost and Length of Stay in a Cohort of 21,875 Patients with Severe Burn
Hauc S, Stögner V, Ihnat J, Hosseini H, Huelsboemer L, Kauke-Navarro M, Rivera J, Williams M, Glahn J, Savetamal A, Pomahac B. Understanding the Drivers of Cost and Length of Stay in a Cohort of 21,875 Patients with Severe Burn. Journal Of Burn Care & Research 2023, 45: 425-431. PMID: 37882472, DOI: 10.1093/jbcr/irad168.Peer-Reviewed Original ResearchLength of stayNational Inpatient SampleThird-degree burnsSkin graftsSevere burnsMajor operating room proceduresLonger LOSPost-operative complicationsBurn-related deathsCost of hospitalizationICD-9 codesImproved mortality ratesOperating room proceduresDrivers of costSecond-degree burnsOnly patientsPatient characteristicsSurgery patientsElectrolyte imbalanceInpatient SampleIndividual patientsInpatient dataComplex careRepresentative cohortPatientsVascularized Composite Allograft Versus Prosthetic for Reconstruction After Facial and Hand Trauma
Noel O, Dumbrava M, Daoud D, Kammien A, Kauke-Navarro M, Pomahac B, Colen D. Vascularized Composite Allograft Versus Prosthetic for Reconstruction After Facial and Hand Trauma. Annals Of Plastic Surgery 2023, 92: 100-105. PMID: 37962243, DOI: 10.1097/sap.0000000000003731.Peer-Reviewed Original ResearchConceptsHand traumaHand/upper extremityLong-term outcomesUpper extremity traumaDifferent reconstructive optionsUse of prosthesesExtremity traumaBenefit profileUpper extremityReconstructive optionsComposite allotransplantationFace traumaHand reconstructionTraumaClinical realityPrimary optionProsthesisPatientsVCAAdvancing Face Transplantation: A Critical Analysis of Revisions and Long-Term Surgical Outcomes in 10 Cases
Mookerjee V, Kauke-Navarro M, Hauc S, Huelsboemer L, Formica R, Pomahac B. Advancing Face Transplantation: A Critical Analysis of Revisions and Long-Term Surgical Outcomes in 10 Cases. Plastic & Reconstructive Surgery 2023, 154: 577e-584e. PMID: 37699110, DOI: 10.1097/prs.0000000000011058.Peer-Reviewed Original ResearchMedical recordsLong-term surgical outcomesFace transplantationChronic allograft rejectionMedian time intervalLong-term outcomesComplex facial injuriesPatients' medical recordsFace transplantFace transplant recipientsAllograft rejectionTransplant recipientsSurgical revisionSurgical outcomesMajority of revisionsOperative reportsRevision surgeryProvider teamRetrospective analysisTEN casesFacial injuriesPeriorbital tissuesPatientsTransplantationMost interventionsThe surgical patient of yesterday, today, and tomorrow—a time-trend analysis based on a cohort of 8.7 million surgical patients
Knoedler S, Matar D, Friedrich S, Knoedler L, Haug V, Hundeshagen G, Kauke-Navarro M, Kneser U, Pomahac B, Orgill D, Panayi A. The surgical patient of yesterday, today, and tomorrow—a time-trend analysis based on a cohort of 8.7 million surgical patients. International Journal Of Surgery 2023, 109: 2631-2640. PMID: 37788019, PMCID: PMC10498871, DOI: 10.1097/js9.0000000000000511.Peer-Reviewed Original ResearchConceptsSurgical patientsMedian ageMedian BMISurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseACS-NSQIP databaseImprovement Program databaseObesity class IProportion of patientsCohort of patientsPrevalence of diabetesType 2 diabetesGlobal healthcare deliveryFuture surgical careField of surgeryTime trend analysisPatient ageSurgical cohortDiabetes prevalenceProgram databaseSurgical careAmerican CollegeGeneral populationPatientsCellular activation pathways and interaction networks in vascularized composite allotransplantation
Knoedler L, Knoedler S, Panayi A, Lee C, Sadigh S, Huelsboemer L, Stoegner V, Schroeter A, Kern B, Mookerjee V, Lian C, Tullius S, Murphy G, Pomahac B, Kauke-Navarro M. Cellular activation pathways and interaction networks in vascularized composite allotransplantation. Frontiers In Immunology 2023, 14: 1179355. PMID: 37266446, PMCID: PMC10230044, DOI: 10.3389/fimmu.2023.1179355.Peer-Reviewed Original ResearchConceptsVascularized Composite AllotransplantationComposite allotransplantationRecipient-derived lymphocytesTreatment of patientsCellular activation pathwaysMultidrug immunosuppressionVCA graftsVCA patientsVCA rejectionGraft rejectionDevastating injuriesClinical managementNovel therapiesReconstructive surgeryLimb lossRejection responseFacial disfigurementAllotransplantationPatientsGraftActivation pathwayTissue cellsDifferent cell typesTissue typesCell typesPostoperative free flap monitoring in reconstructive surgery—man or machine?
Knoedler S, Hoch C, Huelsboemer L, Knoedler L, Stögner V, Pomahac B, Kauke-Navarro M, Colen D. Postoperative free flap monitoring in reconstructive surgery—man or machine? Frontiers In Surgery 2023, 10: 1130566. PMID: 36911625, PMCID: PMC9992807, DOI: 10.3389/fsurg.2023.1130566.Peer-Reviewed Original ResearchFree flap monitoringElderly patientsClinical examinationFlap monitoringAge-related morphologic changesFlap survival rateFree flap reconstructionFree tissue transferComplex tissue defectsPerioperative algorithmOlder patientsCancer resectionFlap appearancePrompt interventionClinical signsFlap reconstructionFree flapFlap compromiseSurvival rateMicrovascular anastomosisTissue transferTissue defectsMorphologic changesPostoperative free flap monitoringPatients
2021
The Modified 5-item Frailty Index Is a Risk Predictor in Breast Reconstruction: An Analysis of 40,415 Patients
Panayi A, Foroutanjazi S, Parikh B, Haug V, Kauke-Navarro M, Diehm Y, Pomahac B. The Modified 5-item Frailty Index Is a Risk Predictor in Breast Reconstruction: An Analysis of 40,415 Patients. Journal Of The American College Of Surgeons 2021, 233: s30. DOI: 10.1016/j.jamcollsurg.2021.07.037.Peer-Reviewed Original Research
2019
The Importance of Serological Procalcitonin Levels After Autologous Microsurgical Transplantation
Safi AF, Schröder K, Kauke M, Safi S, Zöller JE, Zinser M. The Importance of Serological Procalcitonin Levels After Autologous Microsurgical Transplantation. Journal Of Craniofacial Surgery 2019, Publish Ahead of Print: &na;. PMID: 30817542, DOI: 10.1097/scs.0000000000005431.Peer-Reviewed Original ResearchConceptsSoft tissue defectsPCT levelsProcalcitonin levelsSystemic inflammationMicrosurgical interventionTissue defectsPCT cutoff levelPerioperative systemic inflammationHigh mortality rateMicrovascular transplantsMicrovascular transplantationSevere complicationsSevere morbidityRetrospective studySurgical interventionTransplant lossMicrosurgical transplantationTreatment strategiesInclusion criteriaCutoff levelMortality ratePatientsReconstructive surgeonPathological levelsDetectable increase
2018
Evaluation of Fronto-Orbital Advancement Using Titanium-Based Internal Fixation for Corrective Pediatric Craniofacial Surgery
Kreppel M, Kauke M, Grandoch A, Safi AF, Nickenig HJ, Zöller J. Evaluation of Fronto-Orbital Advancement Using Titanium-Based Internal Fixation for Corrective Pediatric Craniofacial Surgery. Journal Of Craniofacial Surgery 2018, 29: 1542-1545. PMID: 29916974, DOI: 10.1097/scs.0000000000004689.Peer-Reviewed Original ResearchConceptsFronto-orbital advancementPediatric craniofacial surgerySecondary surgeryEsthetic outcomeFixation systemRigid fixation systemsRate of complicationsCraniofacial surgeryInternal rigid fixationPlate fixation systemComplication rateSurgical drainsInternal fixationMean durationSecond HospitalSecondary interventionsMedical recordsInternal fixation systemWhitaker scoreRigid fixationSurgeryPatientsBone fragmentsComplicationsCranial vaultClinical evaluation of non-syndromic scaphocephaly surgically corrected with the procedure of total vertex craniectomy
Kreppel M, Kauke M, Safi AF, Grandoch A, Pocek-Behn N, Nickenig HJ, Zöller J. Clinical evaluation of non-syndromic scaphocephaly surgically corrected with the procedure of total vertex craniectomy. Journal Of Cranio-Maxillofacial Surgery 2018, 46: 1465-1469. PMID: 29960814, DOI: 10.1016/j.jcms.2018.05.057.Peer-Reviewed Original ResearchConceptsTime of surgeryStandardized operative techniqueSingle-surgeon approachMonths of ageReoperation rateMajor complicationsCorrective surgeryMean durationClinical evaluationSurgical correctionSurgical methodsOperative techniqueWhitaker scoreRetrospective evaluationSurgeon's approachCraniectomyAesthetic outcomeYoung individualsMonthsPatientsSurgeryScaphocephalyCategory IVCategory IOutcomesSarcomas of the sinonasal tract
Kauke M, Safi A, Grandoch A, Nickenig H, Zöller J, Kreppel M. Sarcomas of the sinonasal tract. Head & Neck 2018, 40: 1279-1286. PMID: 29443431, DOI: 10.1002/hed.25108.Peer-Reviewed Original ResearchConceptsDisease-free survivalSinonasal sarcomaSingle-institution retrospective cohort studyMultimodal therapeutic regimensRetrospective cohort studyOverall survival rateDFS ratesCohort studySinonasal tractTherapeutic regimensMultimodal therapyPrimary tumorDestructive neoplasmSurvival rateSarcomaTherapeutic assessmentSurgeryPrognosisAgeDisease recognitionRegimensPatientsNeoplasmsTherapyNodalClinical Evaluation of Standardized Fronto-Orbital Advancement for Correction of Isolated Trigonocephaly
Safi AF, Kreppel M, Grandoch A, Kauke M, Nickenig HJ, Zöller J. Clinical Evaluation of Standardized Fronto-Orbital Advancement for Correction of Isolated Trigonocephaly. Journal Of Craniofacial Surgery 2018, 29: 72-75. PMID: 29040150, DOI: 10.1097/scs.0000000000004058.Peer-Reviewed Original ResearchConceptsFronto-orbital advancementClinical outcomesPatient cohortWhitaker scoreLow complication rateMean operation timeTreatment-naive childrenPostoperative complicationsComplication rateMajor complicationsCorrective surgeryDural tearRetrospective studySubdural hematomaMean ageClinical evaluationInclusion criteriaFronto-orbital advancement proceduresClinical successFrontoorbital advancementPatientsMorphological outcomesTrigonocephalyOperation timeAdvancement procedureRigid External Distractor-Aided Advancement After Simultaneously Performed LeFort-III Osteotomy and Fronto-Orbital Advancement
Safi AF, Kreppel M, Kauke M, Grandoch A, Nickenig HJ, Zöller J. Rigid External Distractor-Aided Advancement After Simultaneously Performed LeFort-III Osteotomy and Fronto-Orbital Advancement. Journal Of Craniofacial Surgery 2018, 29: 170-174. PMID: 29068973, DOI: 10.1097/scs.0000000000004061.Peer-Reviewed Original ResearchConceptsFronto-orbital advancementLeFort III osteotomyStandardized treatment protocolTreatment protocolEsthetic outcomeDistraction osteogenesisPerioperative hemoglobin concentrationRigid external distractor deviceConventional surgical techniquesDuration of operationLow infection rateLeft temporal siteRigid external distractorPostoperative complicationsCorrective surgeryRetrospective studySkeletal advancementSurgical outcomesFunctional outcomeFunctional resultsSurgical methodsSurgical techniquePatientsHemoglobin concentrationInfection rate