2024
Criteria for PAVM Reintervention
Fish A, Knight E, Henderson K, Pollak J, Schlachter T. Criteria for PAVM Reintervention. Journal Of Clinical Medicine 2024, 13: 6104. PMID: 39458055, PMCID: PMC11508501, DOI: 10.3390/jcm13206104.Peer-Reviewed Original ResearchParadoxical embolismRetrospective review of patientsReview of patientsModern embolization techniquesRetrospective reviewEmbolization techniquesReinterventionScreening intervalEmbolizationLifetime prevalence ratesPatientsRecurrencePAVMsHemoptysisSpontaneous eventsPrevalence ratesCenters of excellenceReperfusionCriteria
2021
Incidence of Spontaneous Pulmonary AVM Rupture in HHT Patients
Fish A, Henderson K, Moushey A, Pollak J, Schlachter T. Incidence of Spontaneous Pulmonary AVM Rupture in HHT Patients. Journal Of Clinical Medicine 2021, 10: 4714. PMID: 34682838, PMCID: PMC8540859, DOI: 10.3390/jcm10204714.Peer-Reviewed Original ResearchAVM ruptureHHT patientsPulmonary hemorrhagePulmonary AVMsLife-threatening complicationsInitial presentationTrue incidenceEmbolization techniquesSpontaneous ruptureSingle lifetime episodeSubsequent embolizationLifetime prevalenceLifetime episodesPatientsIncidenceComplicationsHemorrhageAVMRuptureHemothoraxEmbolizationHydrothoraxLesionsPrevalenceCases
2020
Subaortic Membranes in Patients With Hereditary Hemorrhagic Telangiectasia and Liver Vascular Malformations
Kim AS, Henderson KJ, Pawar S, Kim MJ, Punjani S, Pollak JS, Fahey JT, Garcia‐Tsao G, Sugeng L, Young LH. Subaortic Membranes in Patients With Hereditary Hemorrhagic Telangiectasia and Liver Vascular Malformations. Journal Of The American Heart Association 2020, 9: e016197. PMID: 33054561, PMCID: PMC7763373, DOI: 10.1161/jaha.120.016197.Peer-Reviewed Original ResearchMeSH KeywordsActivin Receptors, Type IICardiac Output, HighDiscrete Subaortic StenosisEchocardiographyFemaleHeart Defects, CongenitalHeart FailureHumansLiverMaleMiddle AgedMutationPrognosisRetrospective StudiesSurvival AnalysisTelangiectasia, Hereditary HemorrhagicUnited StatesVascular MalformationsConceptsHigh-output cardiac failureHereditary hemorrhagic telangiectasiaLeft ventricular outflow tractVentricular outflow tractHemorrhagic telangiectasiaMild obstructionSubaortic membraneVascular malformationsOutflow tractActivin receptor-like kinase 1 mutationsHereditary hemorrhagic telangiectasia patientsLiver vascular malformationsMild aortic insufficiencyPulmonary artery pressureRight heart catheterizationCohort of patientsRetrospective observational analysisHigh cardiac outputKinase 1 mutationsArtery pressureHeart catheterizationPulmonary hypertensionAortic insufficiencyBackground PatientsTricuspid regurgitationGenotype–Phenotype Correlations in Children with HHT
Kilian A, Latino GA, White AJ, Clark D, Chakinala MM, Ratjen F, McDonald J, Whitehead K, Gossage JR, Lin D, Henderson K, Pollak J, McWilliams JP, Kim H, Lawton MT, Faughnan ME, . Genotype–Phenotype Correlations in Children with HHT. Journal Of Clinical Medicine 2020, 9: 2714. PMID: 32842615, PMCID: PMC7565052, DOI: 10.3390/jcm9092714.Peer-Reviewed Original ResearchBrain vascular malformationsHereditary hemorrhagic telangiectasiaPulmonary arteriovenous malformationsGenotype-phenotype correlationVascular malformationsArteriovenous malformationsHHT patientsCentral nervous systemRare autosomal dominant diseaseChi-square testAutosomal dominant diseaseGastrointestinal bleedingPediatric patientsMucocutaneous telangiectasiaHemorrhagic telangiectasiaGreater prevalenceNervous systemPatientsPhenotypic presentationDominant diseaseMalformationsAdultsChildrenTelangiectasiaMutations
2018
Applicability of the Curaçao Criteria for the Diagnosis of Hereditary Hemorrhagic Telangiectasia in the Pediatric Population
Pahl KS, Choudhury A, Wusik K, Hammill A, White A, Henderson K, Pollak J, Kasthuri RS. Applicability of the Curaçao Criteria for the Diagnosis of Hereditary Hemorrhagic Telangiectasia in the Pediatric Population. The Journal Of Pediatrics 2018, 197: 207-213. PMID: 29655863, DOI: 10.1016/j.jpeds.2018.01.079.Peer-Reviewed Original ResearchTHREE TYPES OF INTRAHEPATIC SHUNTS PRESENTING IN A SINGLE PATIENT WITH HEREDITARY HEMORRHAGIC TELANGIECTASIA
Brandt E, Haghighat L, Garcia-Tsao G, Henderson K, Pollak J, Proctor D, Young L. THREE TYPES OF INTRAHEPATIC SHUNTS PRESENTING IN A SINGLE PATIENT WITH HEREDITARY HEMORRHAGIC TELANGIECTASIA. Journal Of The American College Of Cardiology 2018, 71: a2393. DOI: 10.1016/s0735-1097(18)32934-6.Peer-Reviewed Case Reports and Technical Notes6 A Novel Association Between High Red Blood Cell Alloimmunization Rates and Hereditary Hemorrhagic Telangiectasia (HHT)
Zheng Y, Pollak J, Henderson K, Hendrickson J, Tormey C. 6 A Novel Association Between High Red Blood Cell Alloimmunization Rates and Hereditary Hemorrhagic Telangiectasia (HHT). American Journal Of Clinical Pathology 2018, 149: s166-s166. DOI: 10.1093/ajcp/aqx149.375.Peer-Reviewed Original ResearchHereditary hemorrhagic telangiectasiaAlloimmunization rateRBC transfusionHHT patientsHemorrhagic telangiectasiaRed blood cell transfusionFirst RBC transfusionMore RBC transfusionsNon-ABO alloantibodiesProphylactic antigen matchingRBC alloimmunization rateBlood cell transfusionMultiple arteriovenous malformationsStudent's t-testAutosomal dominant disorderCommon alloantibodiesHHT subjectsCell transfusionReferral centerControl patientsMale patientsAntigen matchingRetrospective studyAntibody screenPatient population
2017
Clinical Significance of Pulmonary Arteriovenous Malformation Reperfusion
Kaufman C, Henderson K, Pollak J. Clinical Significance of Pulmonary Arteriovenous Malformation Reperfusion. Journal Of Clinical Interventional Radiology ISVIR 2017, 01: 156-160. DOI: 10.1055/s-0037-1604096.Peer-Reviewed Original ResearchSymptomatic patientsClinical significancePulmonary arteriovenous malformation (PAVM) embolizationTime of diagnosisPulmonary arteriovenous malformationsTime of embolizationTime of presentationArteriovenous malformation embolizationHHT CenterInitial embolizationMedical comorbiditiesRetrospective reviewClinical historySevere manifestationsPAVM embolizationArteriovenous malformationsInitial procedureEmbolization proceduresTreatment periodEmbolizationPatientsMild manifestationsReperfusionSymptomsPAVMsPulmonary Hypertension Prevalence and Prognosis in a Cohort of Patients with Hereditary Hemorrhagic Telangiectasia Undergoing Embolization of Pulmonary Arteriovenous Malformations
Chizinga M, Rudkovskaia AA, Henderson K, Pollak J, Garcia-Tsao G, Young LH, Fares WH. Pulmonary Hypertension Prevalence and Prognosis in a Cohort of Patients with Hereditary Hemorrhagic Telangiectasia Undergoing Embolization of Pulmonary Arteriovenous Malformations. American Journal Of Respiratory And Critical Care Medicine 2017, 196: 1353-1356. PMID: 28375020, DOI: 10.1164/rccm.201702-0267le.Peer-Reviewed Original Research
2015
Hemorrhage Rates From Brain Arteriovenous Malformation in Patients With Hereditary Hemorrhagic Telangiectasia
Kim H, Nelson J, Krings T, terBrugge K, McCulloch C, Lawton M, Young W, Faughnan M, Chakinala M, Gossage J, Henderson K, Iyer V, Kasthuri R, Lin D, Mager J, McWilliams J, McDonald J, Pawlikowska L, Pollak J, Ratjen F, Swanson K, Vethanayagam D, White A, White R, Wilcox P. Hemorrhage Rates From Brain Arteriovenous Malformation in Patients With Hereditary Hemorrhagic Telangiectasia. Stroke 2015, 46: 1362-1364. PMID: 25858236, PMCID: PMC4415515, DOI: 10.1161/strokeaha.114.007367.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAneurysm, RupturedChildChild, PreschoolCohort StudiesFemaleHumansInfantInfant, NewbornIntracranial Arteriovenous MalformationsIntracranial HemorrhagesMaleMiddle AgedRecurrenceRetrospective StudiesSocioeconomic FactorsSurvival AnalysisTelangiectasia, Hereditary HemorrhagicYoung AdultConceptsHereditary hemorrhagic telangiectasiaBrain arteriovenous malformationsICH rateArteriovenous malformationsHemorrhage rateHemorrhagic telangiectasiaHigher ICH ratesIntracranial hemorrhage rateMajority of patientsICH presentationSymptomatic casesSystemic diseaseICH eventsMean ageAsymptomatic screeningMucocutaneous telangiectasiaHHT patientsHigh riskUnruptured casesPatientsMalformationsDiagnosisTelangiectasiaRehemorrhageEpistaxis
2013
Bevacizumab: Finding its niche in the treatment of heart failure secondary to liver vascular malformations in hereditary hemorrhagic telangiectasia
Young LH, Henderson KJ, White RI, Garcia‐Tsao G. Bevacizumab: Finding its niche in the treatment of heart failure secondary to liver vascular malformations in hereditary hemorrhagic telangiectasia. Hepatology 2013, 58: 442-445. PMID: 23686865, DOI: 10.1002/hep.26472.Commentaries, Editorials and Letters
2012
Brain arteriovenous malformations associated with hereditary hemorrhagic telangiectasia: Gene–phenotype correlations
Nishida T, Faughnan ME, Krings T, Chakinala M, Gossage JR, Young WL, Kim H, Pourmohamad T, Henderson KJ, Schrum SD, James M, Quinnine N, Bharatha A, terBrugge KG, White RI. Brain arteriovenous malformations associated with hereditary hemorrhagic telangiectasia: Gene–phenotype correlations. American Journal Of Medical Genetics Part A 2012, 158A: 2829-2834. PMID: 22991266, PMCID: PMC3610331, DOI: 10.1002/ajmg.a.35622.Peer-Reviewed Original ResearchMeSH KeywordsActivin Receptors, Type IIAdolescentAdultAgedAntigens, CDArteriovenous FistulaChildChild, PreschoolEndoglinFemaleGenetic Association StudiesHumansInfantInfant, NewbornIntracellular Signaling Peptides and ProteinsIntracranial Arteriovenous MalformationsMaleMiddle AgedMutationReceptors, Cell SurfaceSmad4 ProteinTelangiectasia, Hereditary HemorrhagicYoung AdultConceptsBrain arteriovenous malformationsHereditary hemorrhagic telangiectasiaHistory of ICHIntracranial hemorrhageArteriovenous malformationsMean ageVascular malformationsHemorrhagic telangiectasiaMultiple brain arteriovenous malformationsAutosomal dominant genetic diseaseDominant genetic diseaseGenetic test resultsAVM characteristicsClinical manifestationsAVM diagnosisPatientsInitial examinationMultiple organsLarger studyACVRL1 mutationsENG mutationsMalformationsAgeSignificant differencesManifestationsThe Young's Procedure for Severe Epistaxis from Hereditary Hemorrhagic Telangiectasia
Richer SL, Geisthoff UW, Livada N, Ward PD, Johnson L, Mainka A, Henderson KJ, Maune S, White RI, Ross DA. The Young's Procedure for Severe Epistaxis from Hereditary Hemorrhagic Telangiectasia. American Journal Of Rhinology And Allergy 2012, 26: 401-404. PMID: 23168156, DOI: 10.2500/ajra.2012.26.3809.Peer-Reviewed Original ResearchConceptsHereditary hemorrhagic telangiectasiaSevere epistaxisYoung's procedureHemorrhagic telangiectasiaGlasgow Benefit Inventory scoreTransfusion-dependent patientsComplete cessationHHT CenterMost patientsSurgical treatmentPostoperative epistaxisSurgical closurePatient outcomesEfficacious procedureSubjective outcomesEpistaxisPatientsMean increaseSevere ironInventory scoresLaser proceduresCessationOutcomesTreatmentTelangiectasia
2011
Reproducibility of Oxygen Saturation Monitoring During Six-Minute Walk Test and Exercise Stress Test in Patients with Pulmonary Arteriovenous Malformations Associated With Hereditary Hemorrhagic Telangiectasia
Li W, Niu B, Henderson K, Northrup V, Pollak JS, Trow T, Fahey J, White RI. Reproducibility of Oxygen Saturation Monitoring During Six-Minute Walk Test and Exercise Stress Test in Patients with Pulmonary Arteriovenous Malformations Associated With Hereditary Hemorrhagic Telangiectasia. Pediatric Cardiology 2011, 32: 590-594. PMID: 21336824, DOI: 10.1007/s00246-011-9917-8.Peer-Reviewed Original ResearchConceptsPulmonary arteriovenous malformationsHereditary hemorrhagic telangiectasiaOxygen saturationHeart rateWalk testArteriovenous malformationsHemorrhagic telangiectasiaSix-minute walk testOxygen saturation monitoringLowest oxygen saturationYears of ageHuman Investigation CommitteeStress testIntraclass correlation coefficientAnatomic subtypesExercise capacityMultiple complicationsPatientsAdjunct testSaturation monitoringAdequate restReproducible measureMalformationsTelangiectasiaBroad spectrum
2010
Overlapping spectra of SMAD4 mutations in juvenile polyposis (JP) and JP-HHT syndrome.
Gallione C, Aylsworth AS, Beis J, Berk T, Bernhardt B, Clark RD, Clericuzio C, Danesino C, Drautz J, Fahl J, Fan Z, Faughnan ME, Ganguly A, Garvie J, Henderson K, Kini U, Leedom T, Ludman M, Lux A, Maisenbacher M, Mazzucco S, Olivieri C, Ploos van Amstel JK, Prigoda-Lee N, Pyeritz RE, Reardon W, Vandezande K, Waldman JD, White RI, Williams CA, Marchuk DA. Overlapping spectra of SMAD4 mutations in juvenile polyposis (JP) and JP-HHT syndrome. American Journal Of Medical Genetics. Part A 2010, 152A: 333-9. PMID: 20101697, DOI: 10.1002/ajmg.a.33206.Peer-Reviewed Original Research
2009
Results of Exercise Stress Testing in Patients with Diffuse Pulmonary Arteriovenous Malformations
Murphy J, Pierucci P, Chyun D, Henderson KJ, Pollak J, White RI, Fahey J. Results of Exercise Stress Testing in Patients with Diffuse Pulmonary Arteriovenous Malformations. Pediatric Cardiology 2009, 30: 978-984. PMID: 19636485, DOI: 10.1007/s00246-009-9491-5.Peer-Reviewed Original ResearchConceptsDiffuse pulmonary arteriovenous malformationsExercise stress testingPulmonary arteriovenous malformationsOxygen saturationMaximum exerciseArteriovenous malformationsRoom air oxygen saturationMean oxygen saturationStress testingCycle ergometer testNoncontrast chestBilateral involvementFrequent complicationComplete embolizationSerial studiesPatientsErgometer testOwn controlYoung adultsNoninvasive methodLimited experienceSignificant differencesMalformationsBaselineAge
2008
Hormonal Therapy for the Treatment of Gastrointestinal Bleeding in Hereditary Hemorrhagic Telangiectasia
Proctor DD, Henderson KJ, Dziura JD, White RI. Hormonal Therapy for the Treatment of Gastrointestinal Bleeding in Hereditary Hemorrhagic Telangiectasia. Journal Of Clinical Gastroenterology 2008, 42: 756-757. PMID: 18496387, DOI: 10.1097/mcg.0b013e318032391f.Peer-Reviewed Original ResearchLong‐term complications of septal dermoplasty in patients with hereditary hemorrhagic telangiectasia
Levine CG, Ross DA, Henderson KJ, Leder SB, White RI. Long‐term complications of septal dermoplasty in patients with hereditary hemorrhagic telangiectasia. Otolaryngology 2008, 138: 721-724. PMID: 18503842, DOI: 10.1016/j.otohns.2008.01.005.Peer-Reviewed Original ResearchConceptsHereditary hemorrhagic telangiectasiaSeptal dermoplastyQuality of lifeHemorrhagic telangiectasiaConsecutive retrospective studyLong-term complicationsLife-threatening epistaxisTreatment of choiceNasal odorConsecutive patientsSinus infectionRetrospective studySense of smellDermoplastyPatientsEpistaxisPotential patientsComplicationsPhone interviewsImproved qualityTelangiectasiaInfectionInitial Experience with 3% Sodium Tetradecyl Sulfate Foam and Fibered Coils for Management of Adolescent Varicocele
Reiner E, Pollak JS, Henderson KJ, Weiss RM, White RI. Initial Experience with 3% Sodium Tetradecyl Sulfate Foam and Fibered Coils for Management of Adolescent Varicocele. Journal Of Vascular And Interventional Radiology 2008, 19: 207-210. PMID: 18341950, DOI: 10.1016/j.jvir.2007.08.013.Peer-Reviewed Original ResearchConceptsInternal spermatic veinSodium tetradecyl sulfate foamSTS foamAdolescent patientsPampiniform plexusSI jointLeft internal spermatic veinRight femoral veinResults of treatmentSurgical recurrenceScrotal discomfortTesticular atrophyCollateral vesselsPhysical examinationFemoral veinSpermatic veinSacroiliac jointAdolescent varicoceleFibered coilsPatientsInitial experienceVaricoceleAdolescent subjectsDeliberate passagePlexusNew Definition and Natural History of Patients With Diffuse Pulmonary Arteriovenous Malformations Twenty-Seven–Year Experience
Pierucci P, Murphy J, Henderson KJ, Chyun DA, White RI. New Definition and Natural History of Patients With Diffuse Pulmonary Arteriovenous Malformations Twenty-Seven–Year Experience. CHEST Journal 2008, 133: 653-661. PMID: 18198252, DOI: 10.1378/chest.07-1949.Peer-Reviewed Original ResearchConceptsDiffuse pulmonary arteriovenous malformationsPulmonary arteriovenous malformationsBilateral involvementArteriovenous malformationsOxygen saturationInitial oxygen saturationSegmental pulmonary arteriesHigh-risk groupOperative deathsLung transplantConsecutive patientsDuodenal ulcerPulmonary arterySignificant morbidityArtery originLiver necrosisFemale genderBrain hemorrhagePatientsMortality rateNatural historyYears' experienceHemoptysisHemorrhageDeath