2024
Procedure Volume and Outcomes With WATCHMAN Left Atrial Appendage Occlusion
Friedman D, Du C, Zimmerman S, Tan Z, Lin Z, Vemulapalli S, Kosinski A, Piccini J, Pereira L, Minges K, Faridi K, Masoudi F, Curtis J, Freeman J. Procedure Volume and Outcomes With WATCHMAN Left Atrial Appendage Occlusion. Circulation Cardiovascular Interventions 2024, 17: e013466. PMID: 38889251, PMCID: PMC11189610, DOI: 10.1161/circinterventions.123.013466.Peer-Reviewed Original ResearchConceptsVolume-outcome relationshipLikelihood of procedural successLeft atrial appendage occlusionProcedural successProcedure volumeAppendage occlusionNational Cardiovascular Data Registry LAAO RegistryVolume quartilesLeft atrial appendage occlusion devicesThree-level hierarchical generalized linear modelsMinimum volume thresholdsWatchman FLX deviceProcedural success rateHierarchical generalized linear modelsAssociated with outcomePhysician volumeWATCHMAN procedureFLX deviceOcclusion deviceVolume thresholdCardiovascular proceduresPhysiciansHospitalNational analysisSuccess rateMedicare Coverage and Patient Out-of-Pocket Costs for Cardiovascular-Kidney-Metabolic Medications
Young G, Bansal K, Riello R, Clark K, Dhruva S, Faridi K, Desai N. Medicare Coverage and Patient Out-of-Pocket Costs for Cardiovascular-Kidney-Metabolic Medications. JAMA Network Open 2024, 7: e2412437. PMID: 38771578, PMCID: PMC11109768, DOI: 10.1001/jamanetworkopen.2024.12437.Peer-Reviewed Original ResearchFactors associated with reporting left ventricular ejection fraction with 3D echocardiography in real‐world practice
Faridi K, Zhu Z, Shah N, Crandall I, McNamara R, Flueckiger P, Bachand K, Lombo B, Hur D, Agarwal V, Reinhardt S, Velazquez E, Sugeng L. Factors associated with reporting left ventricular ejection fraction with 3D echocardiography in real‐world practice. Echocardiography 2024, 41: e15774. PMID: 38329886, DOI: 10.1111/echo.15774.Peer-Reviewed Original ResearchConceptsTransthoracic echocardiogramVentricular ejection fractionOutpatient transthoracic echocardiogramsReal-world practiceEjection fractionLeft ventricular ejection fractionAssess left ventricular ejection fractionInpatient transthoracic echocardiogramsMultivariate logistic regressionLVEFHospitalized patientsMedical CenterSonographersClinical settingLogistic regressionUltrasound machineChemotherapyContrast enhancement agentsPortable studiesNegative association
2023
Atrial fibrillation/atrial flutter related mortality trends in the US population 2010–2020: Regional, racial, sex variations
Ghajar A, Essa M, DeLago A, Parvez A, Aryan Z, Shalhoub J, Hammond‐Haley M, Hartley A, Sargsyan V, Salciccioli J, Faridi K, Nazarian S, Philips B. Atrial fibrillation/atrial flutter related mortality trends in the US population 2010–2020: Regional, racial, sex variations. Pacing And Clinical Electrophysiology 2023, 46: 519-525. PMID: 36527193, DOI: 10.1111/pace.14643.Peer-Reviewed Original ResearchConceptsAF/AFLCause of deathAnnual percentage changeMortality rateAtrial fibrillation/atrial flutterMortality trendsUnderlying causeNon-Hispanic White peopleEpidemiologic Research databaseNon-Hispanic black malesNon-Hispanic black peopleHigh mortality rateJoinpoint regression analysisTotal US populationPrevention WideBlack mortality ratesAtrial flutterObservational studyUrbanization statusResearch DatabaseUS populationDisease controlPercentage changeContributing causeMortality
2022
Rationale and design of a pragmatic trial aimed at improving treatment of hyperlipidemia in outpatients with very high risk atherosclerotic cardiovascular disease: A pragmatic trial of messaging to providers about treatment of hyperlipidemia (PROMPT-LIPID)
Shah NN, Ghazi L, Yamamoto Y, Martin M, Simonov M, Riello RJ, Faridi KF, Ahmad T, Wilson FP, Desai NR. Rationale and design of a pragmatic trial aimed at improving treatment of hyperlipidemia in outpatients with very high risk atherosclerotic cardiovascular disease: A pragmatic trial of messaging to providers about treatment of hyperlipidemia (PROMPT-LIPID). American Heart Journal 2022, 253: 76-85. PMID: 35841944, PMCID: PMC9936562, DOI: 10.1016/j.ahj.2022.07.002.Peer-Reviewed Original ResearchConceptsLipid-lowering therapyAtherosclerotic cardiovascular diseaseTreatment of hyperlipidemiaProportion of patientsElectronic health recordsPragmatic trialHigh riskCardiovascular diseaseProprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitorsHigh-risk atherosclerotic cardiovascular diseaseSubtilisin/kexin type 9 inhibitorsLow-density lipoprotein cholesterol reductionImportant public health implicationsEnrollment of patientsPublic health implicationsUsual careSecondary outcomesPrimary outcomeGuideline recommendationsCholesterol reductionPatientsLDLHyperlipidemiaScalable interventionsOutpatientsDemographic and State-Level Trends in Mortality Due to Ischemic Heart Disease in the United States from 1999 to 2019
Essa M, Ghajar A, Delago A, Hammond-Haley M, Shalhoub J, Marshall D, Salciccioli JD, Sugeng L, Philips B, Faridi KF. Demographic and State-Level Trends in Mortality Due to Ischemic Heart Disease in the United States from 1999 to 2019. The American Journal Of Cardiology 2022, 172: 1-6. PMID: 35317929, DOI: 10.1016/j.amjcard.2022.02.016.Peer-Reviewed Original ResearchConceptsAge-adjusted mortality ratesHigher age-adjusted mortality ratesMortality rateEpidemiologic Research databaseIschemic heart diseaseCrude mortality ratePublic health measuresBlack populationDisease careHeart diseaseHispanic ethnicityHispanic womenResearch DatabaseGreater relative decreaseHispanic menIHDMortality trendsSignificant geographic variationAge groupsHealth measuresDisease controlWhite womenWhite menMortalityMortality decreaseDays at Home After Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients
Chung M, Faridi KF, Kazi DS, Almarzooq ZI, Song Y, Baron SJ, Yeh RW. Days at Home After Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients. JAMA Cardiology 2022, 7: 110-112. PMID: 34668923, PMCID: PMC8529525, DOI: 10.1001/jamacardio.2021.4036.Peer-Reviewed Original Research
2021
Estimation of DAPT Study Treatment Effects in Contemporary Clinical Practice: Findings From the EXTEND-DAPT Study
Butala NM, Faridi KF, Tamez H, Strom JB, Song Y, Shen C, Secemsky EA, Mauri L, Kereiakes DJ, Curtis JP, Gibson CM, Yeh RW. Estimation of DAPT Study Treatment Effects in Contemporary Clinical Practice: Findings From the EXTEND-DAPT Study. Circulation 2021, 145: 97-106. PMID: 34743530, PMCID: PMC8748407, DOI: 10.1161/circulationaha.121.056878.Peer-Reviewed Original ResearchConceptsContemporary clinical practiceStent-treated patientsPercutaneous coronary interventionDAPT studyProlonged DAPTClinical practiceCoronary interventionMyocardial infarctionNational Cardiovascular Data Registry CathPCI RegistryTreatment effectsTrial resultsAttenuation of benefitLonger-duration DAPTMonths of DAPTProlonged DAPT durationDrug-eluting stentsCoronary stent proceduresModern clinical practiceGreater bleedingMore comorbiditiesRegistry patientsAntiplatelet therapyCerebrovascular eventsDAPT durationMore contemporary cohortsNew Heart Failure After Myocardial Infarction (From the National Cardiovascular Data Registries [NCDR] Linked With All-Payer Claims)
Faridi KF, Bhalla N, Atreja N, Venditto J, Khan ND, Wilson T, Fonseca E, Shen C, Yeh RW, Secemsky EA. New Heart Failure After Myocardial Infarction (From the National Cardiovascular Data Registries [NCDR] Linked With All-Payer Claims). The American Journal Of Cardiology 2021, 151: 70-77. PMID: 34053629, DOI: 10.1016/j.amjcard.2021.04.019.Peer-Reviewed Original ResearchConceptsIncident heart failureChronic kidney diseaseAcute myocardial infarctionAdvanced chronic kidney diseaseConcurrent heart failureRecurrent myocardial infarctionHeart failureMyocardial infarctionRisk scoreNational Cardiovascular Data Registry CathPCIChest Pain-MI RegistryHistory of HFNew-onset heart failureTime of MINew heart failureSimplified risk scoreOnset heart failureIndex myocardial infarctionFuture heart failureAfrican American raceSpecific risk factorsCumulative incidenceIndependent predictorsKidney diseaseRisk factorsPrognosis of Claims‐ Versus Trial‐Based Ischemic and Bleeding Events Beyond 1 Year After Coronary Stenting
Butala NM, Faridi KF, Secemsky EA, Song Y, Curtis J, Gibson CM, Kazi D, Shen C, Yeh RW. Prognosis of Claims‐ Versus Trial‐Based Ischemic and Bleeding Events Beyond 1 Year After Coronary Stenting. Journal Of The American Heart Association 2021, 10: e018744. PMID: 33682431, PMCID: PMC8174225, DOI: 10.1161/jaha.120.018744.Peer-Reviewed Original ResearchConceptsUnadjusted mortality ratesIschemic eventsDAPT studyMortality rateEnd pointCox proportional hazards modelPercutaneous coronary interventionProportional hazards modelCardiovascular clinical trialsTrial adjudicationBleeding eventsCathPCI RegistryCoronary interventionCoronary stentingSimilar prognosisPrognostic significanceClinical eventsClinical trialsMedicare claimsAdministrative claimsMortality riskHazards modelPatientsPrognosisDeathLack of Guideline-Directed Medical Therapy in Patients Undergoing Endovascular Procedures for Critical Limb Ischemia
Llanos-Chea F, Jelani QU, Trejo-Paredes C, Curtis JP, Parzynski CS, Huang J, Faridi KF, Turner J, Smolderen KG, Mena-Hurtado C. Lack of Guideline-Directed Medical Therapy in Patients Undergoing Endovascular Procedures for Critical Limb Ischemia. Journal Of The American College Of Cardiology 2021, 77: 1374-1375. PMID: 33706882, DOI: 10.1016/j.jacc.2020.12.063.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsCohort StudiesEndovascular ProceduresFemaleGuideline AdherenceHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIschemiaMaleMiddle AgedPeripheral Arterial DiseasePlatelet Aggregation InhibitorsComparability of Event Adjudication Versus Administrative Billing Claims for Outcome Ascertainment in the DAPT Study
Faridi KF, Tamez H, Butala NM, Song Y, Shen C, Secemsky EA, Mauri L, Curtis JP, Strom JB, Yeh RW. Comparability of Event Adjudication Versus Administrative Billing Claims for Outcome Ascertainment in the DAPT Study. Circulation Cardiovascular Quality And Outcomes 2021, 14: e006589. PMID: 33435731, PMCID: PMC7855905, DOI: 10.1161/circoutcomes.120.006589.Peer-Reviewed Original ResearchConceptsNegative predictive valuePositive predictive valueMyocardial infarctionPredictive valueDAPT studyClinical trialsAdjudicated eventsClaims dataNational Cardiovascular Data Registry CathPCI RegistryClinical events committeeTrial of patientsPercutaneous coronary interventionTrial end pointsKappa statisticsAdjudicated deathCathPCI RegistryCerebrovascular eventsCoronary interventionCumulative incidenceEvents committeeOutcome ascertainmentBilling claimsInpatient hospitalizationBleeding rateCardiovascular disease
2020
Left Ventricular Systolic Function and Inpatient Mortality in Patients Hospitalized with Coronavirus Disease 2019 (COVID-19)
Faridi KF, Hennessey KC, Shah N, Soufer A, Wang Y, Sugeng L, Agarwal V, Sharma R, Sewanan LR, Hur DJ, Velazquez EJ, McNamara RL. Left Ventricular Systolic Function and Inpatient Mortality in Patients Hospitalized with Coronavirus Disease 2019 (COVID-19). Journal Of The American Society Of Echocardiography 2020, 33: 1414-1415. PMID: 32951969, PMCID: PMC7442910, DOI: 10.1016/j.echo.2020.08.016.Peer-Reviewed Original ResearchInpatient Transthoracic Echocardiography during the COVID-19 Pandemic: Evaluating a New Triage Process
Hennessey KC, Shah N, Soufer A, Wang Y, Agarwal V, McNamara RL, Crandall I, Balan S, Pereira J, Kim Y, Hur DJ, Velazquez EJ, Sugeng L, Faridi KF. Inpatient Transthoracic Echocardiography during the COVID-19 Pandemic: Evaluating a New Triage Process. Journal Of The American Society Of Echocardiography 2020, 33: 1418-1419. PMID: 32888760, PMCID: PMC7392041, DOI: 10.1016/j.echo.2020.07.018.Peer-Reviewed Original ResearchValidation of Administrative Claims to Ascertain Outcomes in Pivotal Trials of Transcatheter Aortic Valve Replacement
Butala NM, Strom JB, Faridi KF, Kazi DS, Zhao Y, Brennan JM, Popma JJ, Shen C, Yeh RW. Validation of Administrative Claims to Ascertain Outcomes in Pivotal Trials of Transcatheter Aortic Valve Replacement. JACC Cardiovascular Interventions 2020, 13: 1777-1785. PMID: 32682677, PMCID: PMC7444647, DOI: 10.1016/j.jcin.2020.03.049.Peer-Reviewed Original ResearchMeSH KeywordsAdministrative Claims, HealthcareAgedAged, 80 and overAortic Valve StenosisBioprosthesisClinical Trials as TopicData AccuracyData MiningDatabases, FactualFemaleHealth Services ResearchHeart Valve ProsthesisHumansInternational Classification of DiseasesMaleMedicarePostoperative ComplicationsReproducibility of ResultsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsTranscatheter aortic valve replacementAortic valve replacementNegative predictive valuePositive predictive valueValve replacementPivotal trialsAdministrative claimsPredictive valueAortic valve reinterventionProcedural billing codesAcute kidney injuryPermanent pacemaker implantationKappa agreement statisticsBleeding eventsValve reinterventionKidney injuryTrial patientsPacemaker implantationProcedural complicationsOutcome ascertainmentTrial endpointsClinical endpointsMyocardial infarctionInpatient claimsClinical trialsUse of Administrative Claims to Assess Outcomes and Treatment Effect in Randomized Clinical Trials for Transcatheter Aortic Valve Replacement
Strom JB, Faridi KF, Butala NM, Zhao Y, Tamez H, Valsdottir LR, Brennan JM, Shen C, Popma JJ, Kazi DS, Yeh RW. Use of Administrative Claims to Assess Outcomes and Treatment Effect in Randomized Clinical Trials for Transcatheter Aortic Valve Replacement. Circulation 2020, 142: 203-213. PMID: 32436390, PMCID: PMC7672506, DOI: 10.1161/circulationaha.120.046159.Peer-Reviewed Original ResearchConceptsTrial primary end pointPrimary end pointEnd pointSURTAVI trialCause mortalitySecondary outcomesAdjudicated outcomesClinical trialsTrial dataSecondary trial end pointsTranscatheter aortic valve replacementTreatment effectsClaims-based outcomesAortic valve replacementTrial end pointsRandomized clinical trialsMedicare inpatient claimsCardiovascular clinical trialsYears of ageSAVR patientsValve replacementTreatment armsInpatient claimsProcedural outcomesAdministrative claimsPhysician and Hospital Utilization of P2Y12 Inhibitors in ST-Segment–Elevation Myocardial Infarction in the United States
Faridi KF, Garratt KN, Kennedy KF, Maddox TM, Secemsky EA, Butala NM, Yeh RW. Physician and Hospital Utilization of P2Y12 Inhibitors in ST-Segment–Elevation Myocardial Infarction in the United States. Circulation Cardiovascular Quality And Outcomes 2020, 13: e006275. PMID: 32156164, DOI: 10.1161/circoutcomes.119.006275.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiologistsCardiology Service, HospitalClopidogrelDrug UtilizationFemaleHemorrhageHumansMaleMiddle AgedPatient DischargePercutaneous Coronary InterventionPlatelet Aggregation InhibitorsPractice Patterns, Physicians'Prasugrel HydrochloridePurinergic P2Y Receptor AntagonistsReceptors, Purinergic P2Y12RegistriesRetrospective StudiesRisk AssessmentRisk FactorsST Elevation Myocardial InfarctionTicagrelorTime FactorsTreatment OutcomeUnited StatesConceptsST-segment elevation myocardial infarctionP2Y12 inhibitor usePotent P2Y12 inhibitorsP2Y12 inhibitorsSTEMI patientsMyocardial infarctionInhibitor useClopidogrel usePrior percutaneous coronary interventionNew P2Y12 inhibitorsSubstantial hospital variationUse of ticagrelorElevation myocardial infarctionPercutaneous coronary interventionRisk of deathStrongest clinical predictorsNational utilization ratesBackground TicagrelorHospital quartilesCoronary interventionPatient characteristicsClinical predictorsTicagrelor useHospital variationRetrospective study
2019
Comparison of Clinical Trials and Administrative Claims to Identify Stroke Among Patients Undergoing Aortic Valve Replacement
Strom JB, Zhao Y, Faridi KF, Tamez H, Butala NM, Valsdottir LR, Curtis J, Brennan JM, Shen C, Boulware M, Popma JJ, Yeh RW. Comparison of Clinical Trials and Administrative Claims to Identify Stroke Among Patients Undergoing Aortic Valve Replacement. Circulation Cardiovascular Interventions 2019, 12: e008231. PMID: 31694411, PMCID: PMC7212938, DOI: 10.1161/circinterventions.119.008231.Peer-Reviewed Original ResearchMeSH KeywordsAdministrative Claims, HealthcareAgedAged, 80 and overAortic ValveAortic Valve StenosisBrain IschemiaClinical Trials as TopicDatabases, FactualFemaleHeart Valve Prosthesis ImplantationHumansIschemic Attack, TransientMaleMedicareRisk AssessmentRisk FactorsStrokeTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsNegative predictive valueAortic valve replacementCerebrovascular eventsInternational ClassificationPositive predictive valuePredictive valueValve replacementNinth RevisionClinical trialsTenth RevisionBilling codesKaplan-Meier estimatesMedicare inpatient claimsSURTAVI trialClinical event adjudicationDevastating complicationIschemic strokeNeurological eventsCerebrovascular diseaseBilling claimsInpatient claimsEvent adjudicationAdministrative claimsHigh riskTrial participantsGeographic Patterns of Growth for Transcatheter Aortic Valve Replacement in the United States
Kundi H, Faridi KF, Wang Y, Wadhera RK, Valsdottir LR, Popma JJ, Kramer DB, Yeh RW. Geographic Patterns of Growth for Transcatheter Aortic Valve Replacement in the United States. Circulation 2019, 140: 969-971. PMID: 31498696, PMCID: PMC6736630, DOI: 10.1161/circulationaha.119.040788.Peer-Reviewed Original ResearchAd hoc percutaneous coronary intervention in patients with stable coronary artery disease: A report from the National Cardiovascular Data Registry CathPCI Registry
Faridi KF, Rymer JA, Rao SV, Dai D, Wojdyla D, Yeh RW, Wang TY. Ad hoc percutaneous coronary intervention in patients with stable coronary artery disease: A report from the National Cardiovascular Data Registry CathPCI Registry. American Heart Journal 2019, 216: 53-61. PMID: 31401443, DOI: 10.1016/j.ahj.2019.07.004.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedCoronary AngiographyCoronary Artery BypassCoronary Artery DiseaseFemaleHeart FailureHumansLogistic ModelsMaleOdds RatioPercutaneous Coronary InterventionPeripheral Vascular DiseasesPostoperative ComplicationsPostoperative HemorrhageRegistriesRenal Insufficiency, ChronicTreatment OutcomeConceptsStable coronary artery diseaseRisk of AKIPercutaneous coronary interventionAcute kidney injuryCoronary artery diseaseNational Cardiovascular Data Registry CathPCI RegistryCathPCI RegistryCoronary interventionArtery diseaseMultivessel percutaneous coronary interventionCoronary artery bypass graftDiagnostic coronary angiographyArtery bypass graftChronic kidney diseasePeripheral vascular diseaseGlomerular filtration rateChronic total occlusionAKI riskHospital bleedingPCI useKidney injuryCoronary angiographyHeart failureBypass graftUS patients