Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE
Nguyen HB, Jaehne AK, Jayaprakash N, Semler MW, Hegab S, Yataco AC, Tatem G, Salem D, Moore S, Boka K, Gill JK, Gardner-Gray J, Pflaum J, Domecq JP, Hurst G, Belsky JB, Fowkes R, Elkin RB, Simpson SQ, Falk JL, Singer DJ, Rivers EP. Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE. Critical Care 2016, 20: 160. PMID: 27364620, PMCID: PMC4929762, DOI: 10.1186/s13054-016-1288-3.Peer-Reviewed Original ResearchConceptsEarly goal-directed therapyGoal-directed therapySeptic shockSevere sepsisSepsis mortalitySepsis managementSignificant mortality reductionSurviving Sepsis CampaignAcute myocardial infarctionStandard of careEarly sepsis managementHemodynamic pathogenesisUsual careSepsis CampaignStandard careEmergency departmentMyocardial infarctionEarly managementOutcome benefitsClinical trialsMortality reductionTherapyMortalityTrialsCare