2009
microRNA Expression during Trophectoderm Specification
Viswanathan SR, Mermel CH, Lu J, Lu CW, Golub TR, Daley GQ. microRNA Expression during Trophectoderm Specification. PLOS ONE 2009, 4: e6143. PMID: 19582159, PMCID: PMC2702083, DOI: 10.1371/journal.pone.0006143.Peer-Reviewed Original ResearchConceptsEmbryonic stem cellsTrophectoderm specificationPreimplantation developmentMurine embryosFirst cell fate decisionCell fate decisionsTight developmental regulationStem cellsInner cell massCandidate miRNAsNumber of miRNAsStages of embryogenesisRole of microRNAsMiRNA expression changesMammalian developmentTranscription factorsDevelopmental regulationEctopic expressionTarget genesExpression changesTrophectodermal cellsTrophectodermMiRNA expressionFunctional roleMiRNAs
2008
Dicer-dependent pathways regulate chondrocyte proliferation and differentiation
Kobayashi T, Lu J, Cobb BS, Rodda SJ, McMahon AP, Schipani E, Merkenschlager M, Kronenberg HM. Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 1949-1954. PMID: 18238902, PMCID: PMC2538863, DOI: 10.1073/pnas.0707900105.Peer-Reviewed Original ResearchConceptsDicer-dependent pathwaysSkeletal developmentBiogenesis of miRNAsMiRNA target genesMammalian skeletal developmentSmall noncoding RNAsSkeletal growth defectsChondrocyte proliferationSuppress gene expressionNormal skeletal developmentDiverse organismsCritical roleGrowth defectNoncoding RNAsRNA abundanceGene expressionExpression changesMicroarray analysisBiological processesSignaling systemMiRNAsBase pairingDistinct mechanismsIhh-PTHrPHypertrophic chondrocytes