2021
Thermal ablation alone vs thermal ablation combined with transarterial chemoembolization for patients with small (<3 cm) hepatocellular carcinoma
Chai NX, Chapiro J, Petukhova A, Gross M, Kucukkaya A, Raju R, Zeevi T, Elbanan M, Lin M, Perez-Lozada JC, Schlachter T, Strazzabosco M, Pollak JS, Madoff DC. Thermal ablation alone vs thermal ablation combined with transarterial chemoembolization for patients with small (<3 cm) hepatocellular carcinoma. Clinical Imaging 2021, 76: 123-129. PMID: 33592550, PMCID: PMC8217099, DOI: 10.1016/j.clinimag.2021.01.043.Peer-Reviewed Original ResearchConceptsOverall survivalTransarterial chemoembolizationHepatocellular carcinomaThermal ablationTA groupEarly-stage hepatocellular carcinomaMedian overall survivalTherapy-naïve patientsKaplan-Meier analysisMaximum tumor diameterStage hepatocellular carcinomaLog-rank testDrug-eluting beadsSmall hepatocellular carcinomaTerms of TTPHIPAA-compliant IRBSignificant differencesLipiodol-TACELocoregional therapyBCLC stageComplication rateTreatment cohortsTumor diameterAFP levelsPatient group
2020
Therapy of Intermediate-Stage Hepatocellular Carcinoma: Current Evidence and Clinical Practice
Chai N, Chapiro J. Therapy of Intermediate-Stage Hepatocellular Carcinoma: Current Evidence and Clinical Practice. Seminars In Interventional Radiology 2020, 37: 456-465. PMID: 33328701, PMCID: PMC7732559, DOI: 10.1055/s-0040-1719186.Peer-Reviewed Original ResearchIntermediate-stage hepatocellular carcinomaConventional transarterial chemoembolizationHepatocellular carcinomaLocoregional therapyBland embolizationBarcelona Clinic Liver Cancer (BCLC) staging systemImage-guided locoregional therapiesLiver Cancer staging systemDrug-eluting beads TACEIntermediate-stage diseaseLocoregional treatment optionsImmune checkpoint inhibitorsFirst-line therapyCancer (AJCC) staging systemYttrium-90 RadioembolizationClinical evidence pointsThermal ablationNumber of lesionsCheckpoint inhibitorsDEB-TACELocoregional treatmentSelect patientsSurvival benefitTransarterial chemoembolizationClinical evidence