2022
Impact of Chemoembolic Regimen on Immune Cell Recruitment and Immune Checkpoint Marker Expression following Transcatheter Arterial Chemoembolization in a VX2 Rabbit Liver Tumor Model
Berz AM, Santana JG, Iseke S, Gross M, Pekurovsky V, Laage Gaupp F, Savic LJ, Borde T, Gottwald LA, Boustani AM, Gebauer B, Lin M, Zhang X, Schlachter T, Madoff DC, Chapiro J. Impact of Chemoembolic Regimen on Immune Cell Recruitment and Immune Checkpoint Marker Expression following Transcatheter Arterial Chemoembolization in a VX2 Rabbit Liver Tumor Model. Journal Of Vascular And Interventional Radiology 2022, 33: 764-774.e4. PMID: 35346859, PMCID: PMC9344951, DOI: 10.1016/j.jvir.2022.03.026.Peer-Reviewed Original ResearchConceptsTranscatheter arterial chemoembolizationCytotoxic T-lymphocyte-associated protein 4Rabbit liver tumor modelConventional TACEImmune checkpoint marker expressionLiver tumor modelVX2 rabbit liver tumor modelArterial chemoembolizationBicarbonate infusionImmune responseDifferentiation 3T-lymphocyte-associated protein 4Conventional transcatheter arterial chemoembolizationTumor modelCell death protein 1Marker expressionIntratumoral T cellsImmune checkpoint markersT cell infiltrationDeath protein 1Antigen-presenting cellsImmune cell recruitmentNew Zealand white rabbitsZealand white rabbitsAPC infiltration
2017
Intra-arterial embolotherapy for intrahepatic cholangiocarcinoma: update and future prospects
Savic LJ, Chapiro J, Geschwind JH. Intra-arterial embolotherapy for intrahepatic cholangiocarcinoma: update and future prospects. HepatoBiliary Surgery And Nutrition 2017, 6: 7-21. PMID: 28261591, PMCID: PMC5332218, DOI: 10.21037/hbsn.2016.11.02.Peer-Reviewed Original ResearchIntra-arterial therapyConventional transcatheter arterial chemoembolizationLoco-regional therapyIntrahepatic cholangiocarcinomaOnly curative treatment optionUnresectable intrahepatic cholangiocarcinomaCurative treatment optionIntra-arterial administrationTranscatheter arterial chemoembolizationConversion of patientsDrug-eluting beadsTreatment escalationY90-RESystemic chemotherapyDEB-TACEPalliative treatmentProspective trialSurvival benefitArterial chemoembolizationCombination regimensPalliative approachClinical evidenceLate presentationPoor prognosisTherapeutic options