2009
Leptospirosis pulmonary haemorrhage syndrome is associated with linear deposition of immunoglobulin and complement on the alveolar surface
Croda J, Neto A, Brasil R, Pagliari C, Nicodemo A, Duarte M. Leptospirosis pulmonary haemorrhage syndrome is associated with linear deposition of immunoglobulin and complement on the alveolar surface. Clinical Microbiology And Infection 2009, 16: 593-599. PMID: 19778300, DOI: 10.1111/j.1469-0691.2009.02916.x.Peer-Reviewed Original ResearchConceptsLeptospirosis pulmonary hemorrhage syndromePulmonary hemorrhage syndromeLPHS patientsPulmonary hemorrhageAlveolar surfaceLinear depositionUnique histological patternLife-threatening syndromeImmunoglobulin depositsTreatment regimensPathological featuresPresent studyHistological patternLung specimensLung tissueSevere diseaseAlveolar septaHuman leptospirosisLinear stainingSyndromeZoonotic infectionGranular stainingHemorrhageHeterogeneous stainingPatients
2007
The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis
Silva É, Medeiros MA, McBride AJ, Matsunaga J, Esteves GS, Ramos JG, Santos CS, Croda J, Homma A, Dellagostin OA, Haake DA, Reis MG, Ko AI. The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis. Vaccine 2007, 25: 6277-6286. PMID: 17629368, PMCID: PMC1994161, DOI: 10.1016/j.vaccine.2007.05.053.Peer-Reviewed Original ResearchConceptsMajor public health problemRobust antibody responseGolden Syrian hamstersPublic health problemPotential intervention strategiesLethal inoculumSurface-exposed determinantsProtective immunityAntibody responseSterilizing immunityLethal infectionHamster modelVaccine candidatesSubunit vaccineCompanion animalsHealth problemsVeterinary diseasesSyrian hamstersLeptospiral immunoglobulin-like (Lig) proteinsLeptospira interrogansLeptospirosisL. interrogansIntervention strategiesVirulence factorsImmunoglobulin-like proteinLeptospira Immunoglobulin-Like Proteins as a Serodiagnostic Marker for Acute Leptospirosis
Croda J, Ramos JG, Matsunaga J, Queiroz A, Homma A, Riley LW, Haake DA, Reis MG, Ko AI. Leptospira Immunoglobulin-Like Proteins as a Serodiagnostic Marker for Acute Leptospirosis. Journal Of Clinical Microbiology 2007, 45: 1528-1534. PMID: 17360842, PMCID: PMC1865864, DOI: 10.1128/jcm.02344-06.Peer-Reviewed Original ResearchConceptsSerodiagnostic markerDays of illnessLarge disease burdenLeptospira immunoglobulin-like proteinAcute infectionClinical presentationAcute leptospirosisIgM antibodiesAntibody responseDisease burdenPutative virulence determinantsIgM enzymeTimely diagnosisSevere formHealthy individualsMicroagglutination testPatientsUrban outbreaksHigh mortalityInfectious diseasesPathogenic serovarsLeptospirosisImmunosorbent assaySerumSpecific markers
2003
Pathogenic Leptospira species express surface‐exposed proteins belonging to the bacterial immunoglobulin superfamily
Matsunaga J, Barocchi MA, Croda J, Young TA, Sanchez Y, Siqueira I, Bolin CA, Reis MG, Riley LW, Haake DA, Ko AI. Pathogenic Leptospira species express surface‐exposed proteins belonging to the bacterial immunoglobulin superfamily. Molecular Microbiology 2003, 49: 929-946. PMID: 12890019, PMCID: PMC1237129, DOI: 10.1046/j.1365-2958.2003.03619.x.Peer-Reviewed Original ResearchConceptsLig proteinsMammalian cell invasionLambda phage clonesLipoprotein signal peptideYersinia pseudotuberculosis invasinSurface-exposed proteinsBacterial immunoglobulin-like domainImmunoglobulin-like domainsHost cell attachmentLeptospira speciesImmunocytochemical electron microscopySurface-expressed proteinsDomain proteinsSaprophytic Leptospira speciesDomain repeatsLeptospiral pathogenesisRNA transcript expressionSignal peptideLig geneLigB genesHost infectionExpression libraryPathogenic Leptospira speciesTandem repeatsBacterial immunoglobulin