2016
Limonene reduces hyperalgesia induced by gp120 and cytokines by modulation of IL-1 β and protein expression in spinal cord of mice
Piccinelli A, Morato P, dos Santos Barbosa M, Croda J, Sampson J, Kong X, Konkiewitz E, Ziff E, Amaya-Farfan J, Kassuya C. Limonene reduces hyperalgesia induced by gp120 and cytokines by modulation of IL-1 β and protein expression in spinal cord of mice. Life Sciences 2016, 174: 28-34. PMID: 27888114, DOI: 10.1016/j.lfs.2016.11.017.Peer-Reviewed Original ResearchConceptsIL-1βSpinal cordMechanical hyperalgesiaIntrathecal injectionIL-10Electronic von Frey apparatusAbility of gp120SOD expressionAnti-inflammatory actionIL-1β injectionMale Swiss miceIL-1 βIL-1β applicationGp120 administrationGp120 injectionAntihyperalgesic effectIntrathecal administrationMechanical sensitivityPrior administrationCytokine productionSwiss miceBlood samplesSterile salineHyperalgesiaPeripheral increase
2008
Targeted Mutagenesis in Pathogenic Leptospira Species: Disruption of the LigB Gene Does Not Affect Virulence in Animal Models of Leptospirosis
Croda J, Figueira CP, Wunder EA, Santos CS, Reis MG, Ko AI, Picardeau M. Targeted Mutagenesis in Pathogenic Leptospira Species: Disruption of the LigB Gene Does Not Affect Virulence in Animal Models of Leptospirosis. Infection And Immunity 2008, 76: 5826-5833. PMID: 18809657, PMCID: PMC2583567, DOI: 10.1128/iai.00989-08.Peer-Reviewed Original ResearchConceptsPathogenic Leptospira speciesLeptospira speciesAcute disease manifestationsPersistent renal colonizationInoculation of ratsDisease manifestationsHamster modelRenal colonizationPathogenic mechanismsAnimal modelsPersistent colonizationDecrease virulenceLeptospira interrogansHomologous recombinationLeptospirosisVirulence factorsBacterial adherenceImmunoblot analysisCorresponding chromosomal locusWild-type strainCultured cellsFirst evidenceSpectinomycin resistance geneRepeat proteinsTargeted Mutagenesis