2017
Antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of Psidium guineense Sw. and spathulenol
do Nascimento K, Moreira F, Santos J, Kassuya C, Croda J, Cardoso C, do Carmo Vieira M, Ruiz A, Foglio M, de Carvalho J, Formagio A. Antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of Psidium guineense Sw. and spathulenol. Journal Of Ethnopharmacology 2017, 210: 351-358. PMID: 28844678, DOI: 10.1016/j.jep.2017.08.030.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory AgentsAntineoplastic Agents, PhytogenicAntioxidantsAntitubercular AgentsCell Line, TumorCell ProliferationDisease Models, AnimalEdemaFemaleGas Chromatography-Mass SpectrometryHumansInhibitory Concentration 50MaleMiceOils, VolatilePlant ExtractsPlant LeavesPleurisyPsidiumRatsRats, WistarSesquiterpenesConceptsGas chromatography-mass spectrometryNuclear magnetic resonanceAntimycobacterial activityModerate antimycobacterial activityChromatography-mass spectrometryAnti-inflammatory effectsOvarian cancer cell linesAnti-inflammatory potentialAnti-Mycobacterium tuberculosis activityPsidium guineense SwEssential oilCancer cell linesSulforhodamine B assayChromatographic columnPG-1Pleurisy modelInflammatory diseasesOral administrationAntioxidant activityAntimycobacterial propertiesREMA methodTuberculosis activityB assaySignificant inhibitionCell proliferation
2016
Anti-inflammatory, antioxidant and anti-Mycobacterium tuberculosis activity of viridiflorol: The major constituent of Allophylus edulis (A. St.-Hil., A. Juss. & Cambess.) Radlk.
Trevizan L, do Nascimento K, Santos J, Kassuya C, Cardoso C, do Carmo Vieira M, Moreira F, Croda J, Formagio A. Anti-inflammatory, antioxidant and anti-Mycobacterium tuberculosis activity of viridiflorol: The major constituent of Allophylus edulis (A. St.-Hil., A. Juss. & Cambess.) Radlk. Journal Of Ethnopharmacology 2016, 192: 510-515. PMID: 27612433, DOI: 10.1016/j.jep.2016.08.053.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory AgentsAntioxidantsAntitubercular AgentsBenzothiazolesBiphenyl CompoundsCarrageenanChemotaxis, LeukocyteDexamethasoneDisease Models, AnimalDose-Response Relationship, DrugEdemaFemaleGas Chromatography-Mass SpectrometryMaleMiceMycobacterium tuberculosisOils, VolatilePhytotherapyPicratesPlant ExtractsPlant LeavesPlant OilsPlants, MedicinalPleurisySapindaceaeSulfonic AcidsTerpenesTime FactorsConceptsNatural anti-inflammatory agentAnti-inflammatory agentsSubcutaneous injectionOral administrationAnti-Mycobacterium tuberculosis activityAnti-mycobacterial activityAntioxidant activityTotal leucocytesEOAETuberculosis activityMycobacterium tuberculosisGas chromatography-mass spectrometrySignificant inhibitionMiceTraditional medicineEdemaPleurisyPositive controlReference standardDexamethasoneCarrageenanAdministrationModerate antioxidant activityInjectionMajor constituentsSynthesis, in vitro Antiproliferative and Anti-Mycobacterium tuberculosis Activities of Novel β-Carboline Derivatives
Moreira F, Croda J, Sarragiotto M, Foglio M, Ruiz A, Carvalho J, Formagio A. Synthesis, in vitro Antiproliferative and Anti-Mycobacterium tuberculosis Activities of Novel β-Carboline Derivatives. Journal Of The Brazilian Chemical Society 2016, 27: 1398-1405. DOI: 10.5935/0103-5053.20160062.Peer-Reviewed Original ResearchM. tuberculosisNCI/ADRNCI/ADR cellsCell linesAnti-Mycobacterium tuberculosis activityCancer cell linesHuman cancer cell linesAnti-Mycobacterium tuberculosisΒ-carbolinesTumor cell linesGrowth inhibitory activityADR cellsTuberculosis activityOral bioavailabilityHuman tumor cell linesTerminal guanidine groupTuberculosisΒ-carboline derivativesInhibitory activityAntiproliferative activitySignificant activityGreater activityNovel β-carboline derivativesSilico studiesGroup
2014
Evaluation of the anti-mycobacterium tuberculosis activity and in vivo acute toxicity of Annona sylvatic
Araujo R, Neves F, Formagio A, Kassuya C, Stefanello M, Souza V, Pavan F, Croda J. Evaluation of the anti-mycobacterium tuberculosis activity and in vivo acute toxicity of Annona sylvatic. BMC Complementary Medicine And Therapies 2014, 14: 209. PMID: 24974069, PMCID: PMC4082671, DOI: 10.1186/1472-6882-14-209.Peer-Reviewed Original ResearchConceptsVivo acute toxicityAnti-mycobacterial activityLC-MSFirst chemical characterizationAnti-Mycobacterium tuberculosis activityLiquid-liquid partitioningMinimal inhibitory concentrationEthyl acetate fractionChemical characterizationAntituberculosis activitySpectroscopic dataBody weightIsolation of quercetinAcute toxicityChemical fractionationChromatographic analysisFemale Swiss miceMultidrug-resistant Mycobacterium tuberculosis strainsControl of tuberculosisAcute toxicity evaluationToxicity evaluationMycobacterium tuberculosis strainsTuberculosis activityAlmunequinEAF fractions