2021
Risk Factors for Death Among 120,804 Hospitalized Patients with Confirmed COVID-19 in São Paulo, Brazil
da Silva P, de Oliveira S, Escalante J, Almiron M, Tsuha D, Sato H, Menezes P, de Paula R, D’Agostini T, Croda J. Risk Factors for Death Among 120,804 Hospitalized Patients with Confirmed COVID-19 in São Paulo, Brazil. American Journal Of Tropical Medicine And Hygiene 2021, 105: 88-92. PMID: 34061773, PMCID: PMC8274770, DOI: 10.4269/ajtmh.20-1598.Peer-Reviewed Original ResearchConceptsCOVID-19Confirmed COVID-19Characteristics of patientsChronic lung diseaseIntensive care unitChronic cardiovascular diseaseChronic neurological diseaseMore comorbiditiesClinical characteristicsDiabetes mellitusMedian ageCare unitLung diseaseRisk factorsCardiovascular diseaseHigh riskSevere casesElderly individualsPatientsNeurological diseasesSurvival analysisCoronavirus diseaseDiseaseSão PauloDeath
2020
Cost-effectiveness of a Pharmacogenomic Test for Stratified Isoniazid Dosing in Treatment of Active Tuberculosis
Rens N, Groot C, Goldhaber-Fiebert J, Croda J, Andrews J. Cost-effectiveness of a Pharmacogenomic Test for Stratified Isoniazid Dosing in Treatment of Active Tuberculosis. Clinical Infectious Diseases 2020, 71: 3136-3143. PMID: 31905381, PMCID: PMC7819527, DOI: 10.1093/cid/ciz1212.Peer-Reviewed Original ResearchConceptsDrug-susceptible tuberculosisIncremental cost-effectiveness ratioSlow NAT2 acetylatorsWeight-based dosingOne-way sensitivity analysesCost-effectiveness ratioN-acetyltransferase 2 geneEffectiveness of drugsProbabilistic sensitivity analysesPotential clinical impactGeneXpert testActive tuberculosisNAT2 acetylatorsTreatment failurePharmacokinetic variabilityRapid acetylatorsTuberculosis treatmentClinical impactMAIN OUTCOMEPharmacogenomic testsHealth outcomesIsoniazid toxicityInterindividual variabilityPatientsTuberculosisSpirometry results after treatment for pulmonary tuberculosis: comparison between patients with and without previous lung disease: a multicenter study
Mancuzo E, Martins E, Sulmonett N, de Souza Viana V, Croda J, Kritski A, de Queiroz Mello F, de Souza Elias Nihues S, Azevedo K, de Miranda S. Spirometry results after treatment for pulmonary tuberculosis: comparison between patients with and without previous lung disease: a multicenter study. Jornal Brasileiro De Pneumologia 2020, 46: e20180198. PMID: 32130330, PMCID: PMC7462712, DOI: 10.36416/1806-3756/e20180198.Peer-Reviewed Original ResearchConceptsPrevious lung diseasePulmonary tuberculosisLung diseaseRadiological changesMulticenter studyRisk factorsLDS groupFunctional severityFunctional changesSevere radiological changesImpaired pulmonary functionRestrictive lung diseaseObstructive lung diseaseDegree of dyspneaChest X-raySpirometric changesSevere dyspneaPulmonary functionReferral centerClinical dataPatientsSpirometryDiseaseDyspneaSmoking
2019
A fieldable electrostatic air sampler enabling tuberculosis detection in bioaerosols
de Sousa N, Sandström N, Shen L, Håkansson K, Vezozzo R, Udekwu K, Croda J, Rothfuchs A. A fieldable electrostatic air sampler enabling tuberculosis detection in bioaerosols. Tuberculosis 2019, 120: 101896. PMID: 32090857, PMCID: PMC7049907, DOI: 10.1016/j.tube.2019.101896.Peer-Reviewed Original ResearchConceptsTB hotspotsM. tuberculosisActive pulmonary diseaseAirborne M. tuberculosisElectrostatic air samplerInhalation of aerosolsViable Mycobacterium tuberculosisPulmonary diseaseTB controlTB transmissionM. bovis BCGTuberculosisInfectious diseasesMycobacterium tuberculosisBovis BCGTuberculosis detectionMore human livesMolecular signaturesDiseaseCoughPatientsWorld populationInhalationBCGImportant roleInvestigation of Preanalytical Variables Impacting Pathogen Cell-Free DNA in Blood and Urine
Murugesan K, Hogan C, Palmer Z, Reeve B, Theron G, Andama A, Somoskovi A, Steadman A, Madan D, Andrews J, Croda J, Sahoo M, Cattamanchi A, Pinsky B, Banaei N. Investigation of Preanalytical Variables Impacting Pathogen Cell-Free DNA in Blood and Urine. Journal Of Clinical Microbiology 2019, 57: 10.1128/jcm.00782-19. PMID: 31511335, PMCID: PMC6813001, DOI: 10.1128/jcm.00782-19.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusCell-free DNABlood collection tubesUrine samplesLower medianPCR cycle thresholdCollection tubesEDTA blood samplesTB patientsTuberculosis patientsUrine volumeHealthy donorsBlood samplesAttractive biomarkerEDTA tubesPatient samplesBloodWhole urineThawed plasmaUrineUrine preservativeCycle thresholdMedianPatientsPreanalytical factorsSafety and costs of blood transfusion practices in dengue cases in Brazil
Machado A, Negrão F, Croda J, de Medeiros E, dos Santos Pires M. Safety and costs of blood transfusion practices in dengue cases in Brazil. PLOS ONE 2019, 14: e0219287. PMID: 31283788, PMCID: PMC6613682, DOI: 10.1371/journal.pone.0219287.Peer-Reviewed Original ResearchConceptsHospital stayHospitalization timeHospitalisation timeWHO criteriaBlood transfusion componentsCost of hospitalisationWorld Health Organization recommendationsProspective observational studyBlood transfusion practicesPublic health problemTransfused groupBlood transfusionHospitalisation costsTransfusion practiceMedical recordsObservational studyTransfusion componentsWHO recommendationsPatientsTransfusionHealth problemsBlood componentsDengue casesStayHospitalisationDetection, survival and infectious potential of Mycobacterium tuberculosis in the environment: a review of the evidence and epidemiological implications
Martinez L, Verma R, Croda J, Horsburgh C, Walter K, Degner N, Middelkoop K, Koch A, Hermans S, Warner D, Wood R, Cobelens F, Andrews J. Detection, survival and infectious potential of Mycobacterium tuberculosis in the environment: a review of the evidence and epidemiological implications. European Respiratory Journal 2019, 53: 1802302. PMID: 31048345, PMCID: PMC6753378, DOI: 10.1183/13993003.02302-2018.Peer-Reviewed Original ResearchConceptsInfectious tuberculosis patientsTuberculosis patientsTB transmissionCongregate settingsMouse modelGuinea pigsInfectious threatsMycobacterium tuberculosisDroplet nucleiConsistent findingScientific evidenceInfectious potentialEpidemiological implicationsPrimary routeFurther investigationSeminal experimental studiesRecent studiesHuman sourcesEvidencePatientsTuberculosisFindingsStudyInfectiousnessViability
2017
High mortality rate associated with KPC-producing Enterobacter cloacae in a Brazilian hospital
da Silva K, Varella T, dos Santos Bet G, Carvalhaes C, Correa M, Vasconcelos N, Croda J, Gales A, Simionatto S. High mortality rate associated with KPC-producing Enterobacter cloacae in a Brazilian hospital. American Journal Of Infection Control 2017, 46: 108-110. PMID: 28844375, DOI: 10.1016/j.ajic.2017.07.011.Peer-Reviewed Original ResearchResistência às drogas antituberculose na fronteira do Brasil com Paraguai e Bolívia
Marques M, Cunha E, do Socorro Nantua Evangelista M, Basta P, Marques A, Croda J, de Andrade S. Resistência às drogas antituberculose na fronteira do Brasil com Paraguai e Bolívia. BULL PAN AM HEALTH ORGAN 2017, 41: 1. PMID: 28444009, PMCID: PMC6645181, DOI: 10.26633/rpsp.2017.9.Peer-Reviewed Original ResearchConceptsObserved treatmentDrug resistanceAssociated risk factorsPulmonary tuberculosis casesHistory of alcoholismCases of PTBCombination of drugsPatterns of resistanceRespiratory symptomsPTB casesTuberculosis casesDevelopment of resistanceRisk factorsEpidemiological studiesSingle drugHealth actionsSusceptibility testingMultidrug resistanceDiabetesSusceptibility testsAlcoholismPatientsDrugsTreatmentPresence/absenceSeroprevalence of Chikungunya Virus in a Rural Community in Brazil
Cunha R, Trinta K, Montalbano C, Sucupira M, de Lima M, Marques E, Romanholi I, Croda J. Seroprevalence of Chikungunya Virus in a Rural Community in Brazil. PLOS Neglected Tropical Diseases 2017, 11: e0005319. PMID: 28107342, PMCID: PMC5287455, DOI: 10.1371/journal.pntd.0005319.Peer-Reviewed Original ResearchConceptsCases of chikungunyaCHIKV infectionChikungunya virusCHIKV IgMSymptomatic CHIKV infectionIgM-specific antibodiesFeira de SantanaIgG-specific antibodiesEpidemiological surveillance systemBrazilian Epidemiological Surveillance SystemCHIKV IgGModerate seroprevalenceSeropositive patientsJoint painIgG antibodiesCHIKV transmissionFirst serosurveySeroprevalenceInfectionMagnitude of transmissionAntibodiesPatientsFirst caseSerosurveyIgMFrequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals
de Oliveira S, Trajman A, Paniago A, Motta-Castro A, Ruffino-Netto A, Maciel E, Croda J, da Gloria Bonecini-Almeida M. Frequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals. Jornal Brasileiro De Pneumologia 2017, 43: 215-218. PMID: 28746533, PMCID: PMC5687953, DOI: 10.1590/s1806-37562016000000125.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultAIDS-Related Opportunistic InfectionsBrazilCD4 Lymphocyte CountCross-Sectional StudiesFeasibility StudiesFemaleHumansInfectious Disease Incubation PeriodInterferon-gamma Release TestsLatent TuberculosisMaleMiddle AgedReproducibility of ResultsSurveys and QuestionnairesTuberculin TestConceptsInterferon-gamma releaseIndeterminate resultsHIV/AIDSIGRA resultsTuberculin skin test resultsMultivariate logistic regression modelTuberculin skin testSkin test resultsCost-effectiveness studiesLogistic regression modelsAdvanced immunosuppressionAdjusted ORsSkin testClinical variablesMedical recordsHigh prevalenceHigh riskPatientsIGRARoutine useKappa statisticsPLWHAAIDSRegression modelsKappa
2016
Factors associated with anti-TB drug-induced hepatotoxicity and genetic polymorphisms in indigenous and non-indigenous populations in Brazil
Heinrich M, Zembrzuski V, Ota M, Sacchi F, Teixeira R, Acero P, Cunha G, Souza-Santos R, Croda J, Basta P. Factors associated with anti-TB drug-induced hepatotoxicity and genetic polymorphisms in indigenous and non-indigenous populations in Brazil. Tuberculosis 2016, 101: 15-24. PMID: 27865386, DOI: 10.1016/j.tube.2016.07.006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntitubercular AgentsArylamine N-AcetyltransferaseBrazilChemical and Drug Induced Liver InjuryChildChild, PreschoolCross-Sectional StudiesCytochrome P-450 CYP2E1FemaleGenetic Predisposition to DiseaseGenotypeGlutathione TransferaseHumansIncidenceInfantLongitudinal StudiesMaleMiddle AgedPolymorphism, Single NucleotideTuberculosis, PulmonaryYoung AdultConceptsIncidence of hepatotoxicityAdverse drug reactionsIndigenous patientsAnti-TB drug-induced hepatotoxicityNon-conditional logistic regressionClinical-epidemiological factorsClinical-epidemiological variablesNon-Indigenous patientsGenetic polymorphismsRisk of hepatotoxicityDrug-induced hepatotoxicityPolymorphisms of CYP2E1Anti-tuberculosis drugsAcetylation profileTB patientsSerum levelsDrug reactionsGSTM1 polymorphismOdds ratioLiver enzymesNon-Indigenous populationsTherapeutic schemesPharmacogenetic analysisBetter outcomesPatients
2015
Risk Factors for Death from Visceral Leishmaniasis in an Urban Area of Brazil
Druzian A, de Souza A, de Campos D, Croda J, Higa M, Dorval M, Pompilio M, de Oliveira P, Paniago A. Risk Factors for Death from Visceral Leishmaniasis in an Urban Area of Brazil. PLOS Neglected Tropical Diseases 2015, 9: e0003982. PMID: 26274916, PMCID: PMC4537269, DOI: 10.1371/journal.pntd.0003982.Peer-Reviewed Original ResearchConceptsHIV/AIDSVisceral leishmaniasisRisk factorsAdult patientsMortality rateUrban endemic areaProspective cohort studySecondary bacterial infectionHigh mortality rateEndemic urban areaCohort studyEpidemiological profileMean ageUniversity HospitalEndemic areasMultivariate analysisPatientsBacterial infectionsAIDSDeathSignificant increaseHigh rateLeishmaniasisEdemaRelapseChronic symptoms and pulmonary dysfunction in post-tuberculosis Brazilian patients
de Sousa Elias Nihues S, Mancuzo E, Sulmonetti N, Sacchi F, de Souza Viana V, Netto E, Miranda S, Croda J. Chronic symptoms and pulmonary dysfunction in post-tuberculosis Brazilian patients. The Brazilian Journal Of Infectious Diseases 2015, 19: 492-497. PMID: 26254689, PMCID: PMC9427540, DOI: 10.1016/j.bjid.2015.06.005.Peer-Reviewed Original ResearchConceptsChronic respiratory symptomsPulmonary dysfunctionRespiratory symptomsChronic symptomsObstructive disordersPost-tuberculosis patientsPrevious pulmonary diseaseCross-sectional studyPulmonary diseaseRestrictive disordersPulmonary disordersBrazilian patientsHigh prevalenceReportable diseaseFurther interventionDysfunctionSymptomsPatientsPrevalenceLifestyle differencesDisordersAORNon-Indigenous individualsYears of schoolingDiseaseSocioeconomic disadvantage increasing risk for depression among recently diagnosed HIV patients in an urban area in Brazil: cross-sectional study
Nomoto S, Longhi R, de Barros B, Croda J, Ziff E, Konkiewitz E. Socioeconomic disadvantage increasing risk for depression among recently diagnosed HIV patients in an urban area in Brazil: cross-sectional study. AIDS Care 2015, 27: 979-985. PMID: 25741909, DOI: 10.1080/09540121.2015.1017442.Peer-Reviewed Original ResearchConceptsCross-sectional studyDepressive symptomsBeck Depression InventoryHIV/AIDS patientsHIV outpatient servicesHealth-related qualityRisk of depressionLow educational levelLow incomeAntiretroviral therapyHIV patientsPoor qualityHIV infectionAIDS patientsPrevalence ratesDepression InventorySymptomsSocioeconomic disadvantageCognitive-affective factorsDepressionSocioeconomic factorsPatientsDemographic factorsPossible roleEducational level
2014
Direct Costs of Dengue Hospitalization in Brazil: Public and Private Health Care Systems and Use of WHO Guidelines
Machado A, Estevan A, Sales A, da Silva Brabes K, Croda J, Negrão F. Direct Costs of Dengue Hospitalization in Brazil: Public and Private Health Care Systems and Use of WHO Guidelines. PLOS Neglected Tropical Diseases 2014, 8: e3104. PMID: 25188295, PMCID: PMC4154670, DOI: 10.1371/journal.pntd.0003104.Peer-Reviewed Original ResearchConceptsBlood productsPlatelet transfusionsDengue patientsDirect costsDengue casesHealth systemLaboratory-confirmed dengue patientsCross-sectional census studyMedian hospitalization costNumber of hospitalizationsPublic health problemWorld Health Organization guidelinesHealth Organization guidelinesPrivate health systemHealth care systemDengue guidelinesHospitalized dengue casesHospitalized dengue patientsDengue illnessHospitalization costsTransfusion criteriaPatientsDengue hospitalizationsPrivate health care systemHealth problemsHealth-service performance of TB treatment for indigenous and non-indigenous populations in Brazil: a cross-sectional study
Lemos E, Alves A, Oliveira G, Rodrigues M, Martins N, Croda J. Health-service performance of TB treatment for indigenous and non-indigenous populations in Brazil: a cross-sectional study. BMC Health Services Research 2014, 14: 237. PMID: 24885134, PMCID: PMC4049501, DOI: 10.1186/1472-6963-14-237.Peer-Reviewed Original ResearchConceptsNon-Indigenous populationsTB diagnosisPrimary Care Assessment ToolNon-Indigenous patientsCare Assessment ToolCross-sectional studyHealth service performanceTB patientsMost patientsSymptom onsetTB careTB treatmentTuberculosis controlTreatment strategiesMedical appointmentsHome visitsFirst treatmentHealth professionalsHealth servicesPatientsDiagnosisHealthcare qualityTreatmentSocial supportAssessment tool
2013
Evaluation of the traditional and revised world health organization classifications of dengue cases in Brazil
Lima F, Croda M, Muniz D, Gomes I, de Moraes Soares K, Cardoso M, Tauro R, Croda J. Evaluation of the traditional and revised world health organization classifications of dengue cases in Brazil. Clinics 2013, 68: 1299-1304. PMID: 24212835, PMCID: PMC3798712, DOI: 10.6061/clinics/2013(10)02.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionAgedAged, 80 and overBrazilChildChild, PreschoolCross-Sectional StudiesDengueFemaleHospitalizationHospitals, UniversityHumansInfantIntensive Care UnitsMaleMedical RecordsMiddle AgedSeverity of Illness IndexSex DistributionWorld Health OrganizationYoung AdultConceptsCross-sectional studySevere dengueDengue feverRevised classification systemWorld Health Organization classificationWorldwide public health problemDengue hemorrhagic shockRisk of progressionRisk of complicationsDistribution of patientsDengue hemorrhagic feverPublic health problemWarning signsClassification systemWorld Health OrganizationClinical suspicionHemorrhagic shockOrganization classificationUniversity HospitalMedical recordsSevere diseaseHemorrhagic feverSevere casesPatientsClinical practice
2012
Tuberculosis control in a highly endemic indigenous community in Brazil
Croda M, Trajber Z, da Costa Lima R, Croda J. Tuberculosis control in a highly endemic indigenous community in Brazil. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 2012, 106: 223-229. PMID: 22365154, DOI: 10.1016/j.trstmh.2012.01.005.Peer-Reviewed Original ResearchConceptsTB treatmentNon-Indigenous populationsTB patientsTB case fatality rateImplementation of DOTSRetrospective cohort studyCase fatality rateNumber of patientsHIV-positive statusTimes higher mortalityHigh rateCohort studyTB controlCase fatalityDOTS implementationHIV prevalenceTuberculosis controlFatality rateHigh mortalityMultivariate analysisPatientsYoung adultsMortalityPriority groupsIndigenous populations
2009
Leptospirosis pulmonary haemorrhage syndrome is associated with linear deposition of immunoglobulin and complement on the alveolar surface
Croda J, Neto A, Brasil R, Pagliari C, Nicodemo A, Duarte M. Leptospirosis pulmonary haemorrhage syndrome is associated with linear deposition of immunoglobulin and complement on the alveolar surface. Clinical Microbiology And Infection 2009, 16: 593-599. PMID: 19778300, DOI: 10.1111/j.1469-0691.2009.02916.x.Peer-Reviewed Original ResearchConceptsLeptospirosis pulmonary hemorrhage syndromePulmonary hemorrhage syndromeLPHS patientsPulmonary hemorrhageAlveolar surfaceLinear depositionUnique histological patternLife-threatening syndromeImmunoglobulin depositsTreatment regimensPathological featuresPresent studyHistological patternLung specimensLung tissueSevere diseaseAlveolar septaHuman leptospirosisLinear stainingSyndromeZoonotic infectionGranular stainingHemorrhageHeterogeneous stainingPatients