2021
Toxicological analysis and efficacy of 2-phenylchromone on mycobacteria viability and inflammatory response induced by Mycobacterium bovis
Moreira F, Radai J, de Souza V, Berno C, de Araújo F, Andrade-Silva M, Oliveira R, Arena A, de Oliveira Henriques M, Kassuya C, Croda J. Toxicological analysis and efficacy of 2-phenylchromone on mycobacteria viability and inflammatory response induced by Mycobacterium bovis. Phytomedicine Plus 2021, 1: 100117. DOI: 10.1016/j.phyplu.2021.100117.Peer-Reviewed Original ResearchInflammatory responseOral treatmentSplenic phagocytosisTumor necrosis factor levelsAnti-inflammatory actionNecrosis factor levelsAcute oral toxicity testAnti-inflammatory propertiesMycobacterium bovisMycobacterium tuberculosis strainsDifferential leukocyte countsOral toxicity testPleurisy inductionCytokine productionPleurisy modelLeukocyte countMinimum inhibitory concentrationMycobacteria infectionMycobacteria viabilityPleural exudatesLeukocyte migrationTuberculosis strainsVivo modelToxicity signsFactor levels
2020
Blutaparon portulacoides ethanolic extract reduced IL-1β and inflammatory parameters induced by the Mycobacterium complex and carrageenan in mice
Kassuya R, Radai J, Macorini L, Nunes V, Salvador M, Leite P, Oliveira R, Croda J, Arena A, Kassuya C. Blutaparon portulacoides ethanolic extract reduced IL-1β and inflammatory parameters induced by the Mycobacterium complex and carrageenan in mice. Inflammopharmacology 2020, 29: 439-450. PMID: 32910315, DOI: 10.1007/s10787-020-00752-0.Peer-Reviewed Original ResearchMeSH KeywordsAmaranthaceaeAnimalsAnti-Inflammatory AgentsAntitubercular AgentsCarrageenanDisease Models, AnimalDose-Response Relationship, DrugEdemaFemaleInflammationInterleukin-1betaMaleMiceMice, Inbred C57BLMicrobial Sensitivity TestsMycobacterium tuberculosisPlant ExtractsPleurisyRatsRats, WistarConceptsSwiss miceIL-1β levelsC57BL-6 miceEthanolic extractInflammation/infectionSafe new drugsM. tuberculosis growthMechanical hyperalgesiaInflammatory parametersOral treatmentIL-1βPleurisy modelMinimum inhibitory concentrationPharmacoeconomic perspectiveC57BL6 miceComplete adjuvantSubcutaneous injectionOral administrationWistar ratsMiceMycobacterium tuberculosisNew drugsHealth benefitsTuberculosis growthInhibitory concentrationAntibacterial activity of Cinnamomum cassia L. essential oil in a carbapenem- and polymyxin-resistant Klebsiella aerogenes strain
Vasconcelos N, Silva K, Croda J, Simionatto S. Antibacterial activity of Cinnamomum cassia L. essential oil in a carbapenem- and polymyxin-resistant Klebsiella aerogenes strain. Revista Da Sociedade Brasileira De Medicina Tropical 2020, 53: e20200032. PMID: 33027413, PMCID: PMC7534965, DOI: 10.1590/0037-8682-0032-2020.Peer-Reviewed Original ResearchConceptsHigh antibiotic resistanceMultidrug resistance profilesTime-kill methodsBla OXA-1Multidrug-resistant bacteriaMinimum inhibitory concentrationBla TEMBla CTXAntibacterial activityInhibitory effectBroth microdilutionInhibitory concentrationAntibiotic resistanceK. aerogenesOXA-1KPC-2CarbapenemsCinnamomum cassia essential oilL. essential oilCassia essential oilEssential oilCTXActivity
2019
Origanum vulgare L. essential oil inhibits the growth of carbapenem-resistant gram-negative bacteria
Vasconcelos N, Croda J, Silva K, Motta M, Maciel W, Limiere L, Simionatto S. Origanum vulgare L. essential oil inhibits the growth of carbapenem-resistant gram-negative bacteria. Revista Da Sociedade Brasileira De Medicina Tropical 2019, 52: e20180502. PMID: 31271619, DOI: 10.1590/0037-8682-0502-2018.Peer-Reviewed Original ResearchConceptsCarbapenem-resistant strainsAlternative therapeutic optionTime-kill assaysMultidrug-resistant bacteriaTherapeutic optionsMinimum inhibitory concentrationAcinetobacter baumanniiCell countCarbapenemase productionKill assaysOriganum vulgare L. essential oilL. essential oilKlebsiella pneumoniaeInhibitory concentrationDrug developmentResistant bacteriaH treatmentSerratia marcescensAntimicrobial effectNegative bacteria