Primary Prophylaxis to Prevent Tuberculosis Infection in Prison Inmates: A Randomized, Double-Blind, Placebo-Controlled Trial.
Dias de Oliveira R, da Silva Santos A, Reis C, de Cássia Leite A, Correia Sacchi F, de Araujo R, Dos Santos P, Rolla V, Martinez L, Andrews J, Croda J. Primary Prophylaxis to Prevent Tuberculosis Infection in Prison Inmates: A Randomized, Double-Blind, Placebo-Controlled Trial. American Journal Of Tropical Medicine And Hygiene 2020, 103: 1466-1472. PMID: 32876010, PMCID: PMC7543866, DOI: 10.4269/ajtmh.20-0110.Peer-Reviewed Original ResearchConceptsQFT conversionTB infectionSecondary outcomesPlacebo-controlled trialQuantiFERON-TB GoldFuture clinical trialsPrimary prophylaxisMiddle-income countriesPrimary outcomeTuberculosis infectionIntervention armTuberculosis incidenceControl armTrial protocolClinical trialsElevated riskInterim analysisLatent infectionCutoff pointInfectionTrialsHigher cutoffSustained conversionInternational unitsLower ratesDetection of Drug Resistant Mycobacterium Tuberculosis Strains Using Kit SIRE Nitratase®: a Multicenter Study
de Miranda S, de Almeida I, de Fátima Filardi Oliveira Mansur M, de Assis Figueredo L, da Silva Carvalho W, Hadaad J, do Carmo Guimarães Diniz J, von Groll A, da Silva P, Lopes M, dos Santos M, Brito A, de Queiroz Mello F, da Silva Santos Malaquias T, Croda J, Pinhata J, de Oliveira R, Chimara E, Rossetti M, Halon M, Lourenço M, de Melo Medeiros R, Montes F, Machado D, Viveiros M, Kritski A. Detection of Drug Resistant Mycobacterium Tuberculosis Strains Using Kit SIRE Nitratase®: a Multicenter Study. Brazilian Archives Of Biology And Technology 2020, 63: e20190179. DOI: 10.1590/1678-4324-2020190179.Peer-Reviewed Original ResearchLowenstein-Jensen mediumMulticenter studyProportion methodDrug-resistant Mycobacterium tuberculosis strainsResistant Mycobacterium tuberculosis strainsM. tuberculosis clinical isolatesJensen mediumGold standardTuberculosis clinical isolatesMycobacterium tuberculosis resistanceMycobacterium tuberculosis strainsMiddle-income countriesTreatment drugsTuberculosis strainsClinical isolatesTuberculosis resistanceSusceptibility test kitsEthambutolIncome countriesTest kitIsoniazidRifampicinPresent studyKitStreptomycin