Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection
Borba M, Val F, Sampaio V, Alexandre M, Melo G, Brito M, Mourão M, Brito-Sousa J, Baía-da-Silva D, Guerra M, Hajjar L, Pinto R, Balieiro A, Pacheco A, Santos J, Naveca F, Xavier M, Siqueira A, Schwarzbold A, Croda J, Nogueira M, Romero G, Bassat Q, Fontes C, Albuquerque B, Daniel-Ribeiro C, Monteiro W, Lacerda M. Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. JAMA Network Open 2020, 3: e208857. PMID: 32330277, DOI: 10.1001/jamanetworkopen.2020.8857.Peer-Reviewed Original ResearchConceptsHigh dosage groupSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionAcute respiratory syndrome coronavirus 2 infectionLow dosage groupSyndrome coronavirus 2 infectionCoronavirus 2 infectionChloroquine diphosphateDay 13COVID-19Phase IIb clinical trialNonsevere COVID-19Secondary end pointsSevere COVID-19High-dose groupSpecific antiviral therapyTertiary care facilityIIb clinical trialCoronavirus disease 2019More heart diseaseParticipants' clinical statusAdjunctive therapyAdult patientsIll patientsPrimary outcomeAntiviral therapyRisk factors for polymyxin-resistant carbapenemase-producing Enterobacteriaceae in critically ill patients: An epidemiological and clinical study
da Silva K, Baker S, Croda J, Nguyen T, Boinett C, Barbosa L, Tetila A, Simionatto S. Risk factors for polymyxin-resistant carbapenemase-producing Enterobacteriaceae in critically ill patients: An epidemiological and clinical study. International Journal Of Antimicrobial Agents 2020, 55: 105882. PMID: 31923570, DOI: 10.1016/j.ijantimicag.2020.105882.Peer-Reviewed Original ResearchConceptsRisk factorsPolymyxin-resistant strainsNeonatal patientsMortality rateNeonatal intensive care unitEnterobacteriaceae strainsOnly risk factorCentral venous cathetersIntensive care unitCase-control studyPotential risk factorsHigh mortality ratePolymyxin-susceptible strainsCarbapenemase-producing EnterobacteriaceaeCarbapenem exposureAdult patientsAminoglycoside useCarbapenem useRenal failureVenous cathetersIll patientsCare unitUnfavourable outcomePolymerase chain reactionUrinary catheter