2020
Cost-effectiveness of a Pharmacogenomic Test for Stratified Isoniazid Dosing in Treatment of Active Tuberculosis
Rens N, Groot C, Goldhaber-Fiebert J, Croda J, Andrews J. Cost-effectiveness of a Pharmacogenomic Test for Stratified Isoniazid Dosing in Treatment of Active Tuberculosis. Clinical Infectious Diseases 2020, 71: 3136-3143. PMID: 31905381, PMCID: PMC7819527, DOI: 10.1093/cid/ciz1212.Peer-Reviewed Original ResearchConceptsDrug-susceptible tuberculosisIncremental cost-effectiveness ratioSlow NAT2 acetylatorsWeight-based dosingOne-way sensitivity analysesCost-effectiveness ratioN-acetyltransferase 2 geneEffectiveness of drugsProbabilistic sensitivity analysesPotential clinical impactGeneXpert testActive tuberculosisNAT2 acetylatorsTreatment failurePharmacokinetic variabilityRapid acetylatorsTuberculosis treatmentClinical impactMAIN OUTCOMEPharmacogenomic testsHealth outcomesIsoniazid toxicityInterindividual variabilityPatientsTuberculosis
2018
119. Prospective Validation of a 3-Gene Signature for Tuberculosis Diagnosis, Predicting Progression and Evaluating Treatment Response
Warsinske H, Rao A, Moreira F, Dos Santos P, Liu A, Scott M, Malherbe S, Ronacher K, Walzl G, Winter J, Sweeney T, Croda J, Andrews J, Khatri P. 119. Prospective Validation of a 3-Gene Signature for Tuberculosis Diagnosis, Predicting Progression and Evaluating Treatment Response. Open Forum Infectious Diseases 2018, 5: s5-s5. PMCID: PMC6253029, DOI: 10.1093/ofid/ofy209.010.Peer-Reviewed Original ResearchNegative predictive valueTB scoreWorld Health OrganizationActive tuberculosisATB patientsCohort studyTriage testTreatment responseHigh negative predictive valueProspective cohort studyCase-control trialEnd of treatmentIndependent prospective cohortsAdolescent cohort studySputum positivityActive diseaseProspective cohortTreatment initiationSputum testDisease onsetProspective validationPET-CTPredicting ProgressionTuberculosis diagnosisPredictive valueBuilding capacity for advances in tuberculosis research; proceedings of the third RePORT international meeting
van der Heijden Y, Abdullah F, Andrade B, Andrews J, Christopher D, Croda J, Ewing H, Haas D, Hatherill M, Horsburgh C, Mave V, Nakaya H, Rolla V, Srinivasan S, Sugiyono R, Ugarte-Gil C, Hamilton C. Building capacity for advances in tuberculosis research; proceedings of the third RePORT international meeting. Tuberculosis 2018, 113: 153-162. PMID: 30514497, PMCID: PMC6349374, DOI: 10.1016/j.tube.2018.09.009.Peer-Reviewed Original ResearchConceptsType 2 diabetes mellitusTuberculosis researchActive pulmonary tuberculosisHigh-risk populationEnrollment of participantsContext of HIVUnderstanding of tuberculosisHousehold contactsActive tuberculosisObservational cohortPulmonary tuberculosisDiabetes mellitusTuberculosis transmissionClinical dataIncipient tuberculosisNovel biomarkersTB participantsHost immunityStandardized research protocolsTuberculosisResearch capacity developmentHIVResearch protocolBiomarker identificationInternational meetingsSerum vitamin D levels and risk of prevalent tuberculosis, incident tuberculosis and tuberculin skin test conversion among prisoners
Maceda EB, Gonçalves C, Andrews JR, Ko AI, Yeckel CW, Croda J. Serum vitamin D levels and risk of prevalent tuberculosis, incident tuberculosis and tuberculin skin test conversion among prisoners. Scientific Reports 2018, 8: 997. PMID: 29343733, PMCID: PMC5772514, DOI: 10.1038/s41598-018-19589-3.Peer-Reviewed Original ResearchConceptsVitamin D levelsTuberculin skin test conversionPoor vitamin D statusSkin test conversionVitamin D statusActive tuberculosisRisk of progressionCase-control studyD levelsRisk factorsTST conversionD statusCigarette smokingTest conversionSerum vitamin D levelsSubnormal vitamin D levelsMultivariable conditional logistic regressionConditional logistic regressionConsequence of diseaseIncident tuberculosisActive diseaseLatent tuberculosisPrevalent tuberculosisVitamin DBlack race
2016
Epidemiological study of hepatitis B virus among prisoners with active tuberculosis in Central Brazil.
Iglecias L, Puga M, Pompílio M, Teles S, Croda J, Lima L, Lago B, Martins R, Motta-Castro A. Epidemiological study of hepatitis B virus among prisoners with active tuberculosis in Central Brazil. The International Journal Of Tuberculosis And Lung Disease 2016, 20: 1509-1515. PMID: 27776593, DOI: 10.5588/ijtld.15.0743.Peer-Reviewed Original ResearchConceptsHepatitis B virusActive tuberculosisHBV infectionB virusRisk factorsHBV surface antigen prevalenceImportant public health concernCo-infection prevalenceHBsAg-positive samplesCross-sectional studyInfection prevalence ratePublic health concernHBV DNASerological markersOverall prevalenceAntigen prevalencePrevalence ratesEffective treatmentEpidemiological studiesGenotype distributionMultivariate analysisPrison inmatesTuberculosisHealth concernInfectionImpact of mass-screening on tuberculosis incidence in a prospective cohort of Brazilian prisoners
Paião DS, Lemos EF, Carbone AD, Sgarbi RV, Junior AL, da Silva FM, Brandão LM, dos Santos LS, Martins VS, Simionatto S, Motta-Castro AR, Pompílio MA, Urrego J, Ko AI, Andrews JR, Croda J. Impact of mass-screening on tuberculosis incidence in a prospective cohort of Brazilian prisoners. BMC Infectious Diseases 2016, 16: 533. PMID: 27716170, PMCID: PMC5048439, DOI: 10.1186/s12879-016-1868-5.Peer-Reviewed Original ResearchConceptsTuberculin skin testingActive tuberculosisRisk factorsSubsequent diseaseProspective cohort studyEarly case detectionHigh transmission settingsHigh-risk populationPotential risk factorsProportional hazards modelSubsequent disease riskMass screening interventionTST conversionCohort studyProspective cohortHIV testingTuberculosis infectionScreening interventionsSkin testingTB notificationsTuberculosis incidenceSubsequent riskCase detectionSputum samplesActive screening
2013
Impact of Latent Infection Treatment in Indigenous Populations
Yuhara L, Sacchi F, Croda J. Impact of Latent Infection Treatment in Indigenous Populations. PLOS ONE 2013, 8: e71201. PMID: 23936264, PMCID: PMC3729554, DOI: 10.1371/journal.pone.0071201.Peer-Reviewed Original ResearchConceptsSmear-positive index casesTuberculin skin testActive tuberculosisLatent infectionIndex caseInfection treatmentLatent tuberculosisActive diseaseTuberculosis contactsRetrospective studySkin testClinical recordsRisk factorsNotification databaseMultidisciplinary teamClose contactTuberculosisInfectionTreatmentAgeEstimated numberPresent studyMorbidityIndigenous BraziliansCases