2021
Interactions among Long Non-Coding RNAs and microRNAs Influence Disease Phenotype in Diabetes and Diabetic Kidney Disease
Srivastava SP, Goodwin JE, Tripathi P, Kanasaki K, Koya D. Interactions among Long Non-Coding RNAs and microRNAs Influence Disease Phenotype in Diabetes and Diabetic Kidney Disease. International Journal Of Molecular Sciences 2021, 22: 6027. PMID: 34199672, PMCID: PMC8199750, DOI: 10.3390/ijms22116027.Peer-Reviewed Original ResearchConceptsDiabetic kidney diseaseKidney diseaseLarge-scale RNA sequencingGenome-wide profiling dataLong non-coding RNAsNon-coding RNAsDisease phenotypeTherapeutic targetNoncoding RNAsRNA sequencingPathogenesis of diabetesPotential therapeutic targetCrosstalk mechanismsRegulatory microRNAsCrosstalk interactionsLncRNAsMechanism of actionProfiling dataMicroRNAsAberrant expressionDiverse targetsDisease processDiabetesRNADisease
2019
Characterization of Long Noncoding RNA and mRNA Profiles in Sepsis-Induced Myocardial Depression
Zhang TN, Goodwin JE, Liu B, Li D, Wen R, Yang N, Xia J, Zhou H, Zhang T, Song WL, Liu CF. Characterization of Long Noncoding RNA and mRNA Profiles in Sepsis-Induced Myocardial Depression. Molecular Therapy - Nucleic Acids 2019, 17: 852-866. PMID: 31472370, PMCID: PMC6722300, DOI: 10.1016/j.omtn.2019.07.020.Peer-Reviewed Original ResearchGene Ontology term enrichmentMRNA profilesCell apoptosisMyocardial depressionBasic molecular mechanismsLong noncoding RNAPVT1 geneTerm enrichmentNoncoding RNAsRNA sequencingSeptic shockNovel lncRNAMolecular mechanismsRat modelLncRNAsFunctional roleRelated pathwaysC-MycHypodynamic septic shockCaspase-3Intensive care unitExpression of MyD88Bcl-2ApoptosisLeft ventricular tissue