2002
Midtrimester nuchal thickness and the prediction of postnatal congenital heart defect
Bahado-Singh RO, Rowther M, Bailey J, Copel J, Mendilcioglu I, Choi S, Oz U. Midtrimester nuchal thickness and the prediction of postnatal congenital heart defect. American Journal Of Obstetrics And Gynecology 2002, 187: 1250-1253. PMID: 12439514, DOI: 10.1067/mob.2002.128025.Peer-Reviewed Original ResearchConceptsNuchal thickness measurementPrediction of CHDNuchal thicknessRisk factorsHeart defectsStepwise logistic regression analysisBackground population riskIndividual patient's riskEpidemiologic risk factorsSignificant risk factorsMultiple risk factorsPatient-specific riskSignificant predictorsLogistic regression analysisCongenital heart defectsOnly significant predictorMajor CHDPostnatal evaluationPatient riskMidtrimester fetusesNormal fetusesCongenital heartCHDLogistic regression
2001
Ratio of nuchal thickness to humerus length for Down syndrome detection
Bahado-Singh R, Oz U, Hsu C, Deren O, Copel J, Mahoney M. Ratio of nuchal thickness to humerus length for Down syndrome detection. American Journal Of Obstetrics And Gynecology 2001, 184: 1284-1288. PMID: 11349203, DOI: 10.1067/mob.2001.113878.Peer-Reviewed Original ResearchConceptsDown syndrome riskHigh-risk groupMaternal ageSyndrome riskNuchal thicknessDown syndromeDown syndrome detectionStudy populationIndividual Down's syndrome riskMean gestational ageOverall study populationAge-related riskHumerus lengthSyndrome detectionDown syndrome casesDown's syndrome likelihood ratiosGestational ageProspective dataHealthy groupGross anomaliesNormal fetusesSyndrome casesBiparietal diameterAmniocentesis casesFetal population
2000
Splenic artery Doppler peak systolic velocity predicts severe fetal anemia in rhesus disease
Bahado-Singh R, Oz U, Deren O, Kovanchi E, Hsu C, Copel J, Mari G. Splenic artery Doppler peak systolic velocity predicts severe fetal anemia in rhesus disease. American Journal Of Obstetrics And Gynecology 2000, 182: 1222-1226. PMID: 10819862, DOI: 10.1016/s0002-9378(00)70189-x.Peer-Reviewed Original ResearchConceptsDoppler peak systolic velocityPeak systolic velocitySevere anemiaSystolic velocityPrior transfusionsGestational ageHemoglobin deficitStudy groupSplenic artery peak systolic velocityMean peak systolic velocityPeak systolic velocity valuesMean gestational ageOverall study groupSevere fetal anemiaCord blood specimensSystolic velocity valuesNonhydropic fetusesMean hemoglobinRhesus diseaseFetal anemiaFetal hydropsStudy populationBlood specimensNormal fetusesFirst such reportNoninvasive Diagnosis by Doppler Ultrasonography of Fetal Anemia Due to Maternal Red-Cell Alloimmunization
Mari G, Deter R, Carpenter R, Rahman F, Zimmerman R, Moise K, Dorman K, Ludomirsky A, Gonzalez R, Gomez R, Oz U, Detti L, Copel J, Bahado-Singh R, Berry S, Martinez-Poyer J, Blackwell S. Noninvasive Diagnosis by Doppler Ultrasonography of Fetal Anemia Due to Maternal Red-Cell Alloimmunization. New England Journal Of Medicine 2000, 342: 9-14. PMID: 10620643, DOI: 10.1056/nejm200001063420102.Peer-Reviewed Original ResearchMeSH KeywordsBlood Flow VelocityBlood Group IncompatibilityCordocentesisErythroblastosis, FetalErythrocytesFemaleFetal BloodGestational AgeHemoglobinsHumansInfant, NewbornIsoantibodiesMiddle Cerebral ArteryPregnancyPregnancy Complications, HematologicProspective StudiesReference ValuesRh IsoimmunizationROC CurveSensitivity and SpecificityUltrasonography, Doppler, PulsedUltrasonography, PrenatalConceptsMaternal red cell alloimmunizationRed cell alloimmunizationMiddle cerebral arterySystolic blood flowCerebral arteryBlood flowSevere anemiaFetal anemiaDoppler ultrasonographyNormal fetusesHemoglobin concentrationFetal middle cerebral arteryPeak velocityFetal hemoglobin concentrationAbsence of hydropsPeak systolic velocityGestational ageModerate anemiaSystolic velocityHemoglobin valuesMild anemiaInvasive techniquesAlloimmunizationAnemiaArtery
1997
The effect of intravascular blood transfusion on the flow velocity waveform of the portal venous system of the anemic fetus
d'Ancona R, Rahman F, Ozcan T, Copel J, Mari G. The effect of intravascular blood transfusion on the flow velocity waveform of the portal venous system of the anemic fetus. Ultrasound In Obstetrics And Gynecology 1997, 10: 333-337. PMID: 9444047, DOI: 10.1046/j.1469-0705.1997.10050333.x.Peer-Reviewed Original ResearchConceptsFlow velocity waveformsPortal venous systemAnemic fetusesVelocity waveformsPortal hypertensionIntravascular transfusionPortal veinVenous systemNormal fetusesIntravascular blood transfusionNon-pulsatile flowBlood transfusionRhesus alloimmunizationGestational agePulsatile patternTransfusionFetusesPresence of pulsatilityHypertensionIncreased numberCardiac cyclePulsatileVeinAlloimmunizationUteroFirst-trimester growth restriction and fetal aneuploidy: The effect of type of aneuploidy and gestational age
Bahado-Singh R, Lynch L, Deren O, Morroti R, Copel J, Mahoney M, Williams J. First-trimester growth restriction and fetal aneuploidy: The effect of type of aneuploidy and gestational age. American Journal Of Obstetrics And Gynecology 1997, 176: 976-980. PMID: 9166154, DOI: 10.1016/s0002-9378(97)70388-0.Peer-Reviewed Original ResearchConceptsCrown-rump lengthGestational ageTrisomy 18First trimester fetal growthFirst-trimester crown-rump lengthLength shorteningFirst-trimester growth restrictionLast menstrual periodReceiver operator characteristic curveFirst-trimester fetusesPrenatal diagnosis centerWeeks' gestationRisk pregnanciesFetal growthAneuploidy riskControl fetusesGrowth restrictionMenstrual periodNormal groupNormal fetusesTrimester fetusesAneuploid fetusesTrisomy 21Trisomy 13Down syndrome
1996
Adrenal artery velocity waveforms in the appropriate and small‐for‐gestational‐age fetus
Mari G, Uerpairojkit B, Abuhamad A, Copel J. Adrenal artery velocity waveforms in the appropriate and small‐for‐gestational‐age fetus. Ultrasound In Obstetrics And Gynecology 1996, 8: 82-86. PMID: 8883308, DOI: 10.1046/j.1469-0705.1996.08020082.x.Peer-Reviewed Original ResearchConceptsGestational age fetusesArtery pulsatility indexFlow velocity waveformsPulsatility indexVelocity waveformsAdrenal arteryFetal heart rate decelerationsHeart rate decelerationsPreterm deliveryCesarean sectionGestational ageDoppler ultrasonographyAdrenal glandBlood flowHigh incidenceNormal fetusesFetusesRate decelerationConfidence intervalsSuccess rateArteryUltrasonographyGestationIncidence
1995
Abdominal venous system in the normal fetus.
Mari G, Uerpairojkit B, Copel J. Abdominal venous system in the normal fetus. Obstetrics And Gynecology 1995, 86: 729-33. PMID: 7566838, DOI: 10.1016/0029-7844(95)00264-r.Peer-Reviewed Original ResearchConceptsFlow velocity waveformsInferior vena cavaAbdominal venous systemUmbilical sinusNormal fetusesVena cavaPortal veinVenous systemVelocity waveformsDuctus venosusSplenic veinHepatic veinUmbilical veinCommon iliac veinLeft hepatic veinAdrenal veinWeeks' gestationRenal veinIliac veinAnterior divisionPosterior divisionMonophasic patternFetusesCavaBiphasic patternBlood flow velocity waveforms of the abdominal arteries in appropriate‐ and small‐for‐gestational‐age fetuses
Mari G, Abuhamad A, Uerpairojkit B, Martinez E, Copel J. Blood flow velocity waveforms of the abdominal arteries in appropriate‐ and small‐for‐gestational‐age fetuses. Ultrasound In Obstetrics And Gynecology 1995, 6: 15-18. PMID: 8528795, DOI: 10.1046/j.1469-0705.1995.06010015.x.Peer-Reviewed Original ResearchConceptsGestational age fetusesPulsatility index valuesSuperior mesenteric arteryFlow velocity waveformsPulsatility indexSplenic arteryHepatic arteryMesenteric arteryRenal arteryVelocity waveformsAbdominal arteriesLower pulsatility index valuesSuperior mesenteric artery levelColor flow Doppler ultrasonographyBlood flow velocity waveformsHigher pulsatility indexLow pulsatility indexLow vascular resistanceSuccessful insonationArtery levelVascular resistanceDoppler ultrasonographyArterial waveformBlood flowNormal fetusesDiagnosis of fetal anemia with Doppler ultrasound in the pregnancy complicated by maternal blood group immunization
Mari G, Adrignolo A, Abuhamad A, Pirhonen J, Jones D, Ludomirsky A, Copel J. Diagnosis of fetal anemia with Doppler ultrasound in the pregnancy complicated by maternal blood group immunization. Ultrasound In Obstetrics And Gynecology 1995, 5: 400-405. PMID: 7552802, DOI: 10.1046/j.1469-0705.1995.05060400.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemia, HemolyticBlood Flow VelocityBlood Group AntigensCerebral ArteriesCordocentesisErythroblastosis, FetalFemaleFetal BloodGestational AgeHumansInfant, NewbornObserver VariationPregnancyProspective StudiesRetrospective StudiesRh IsoimmunizationROC CurveTransfusion ReactionUltrasonography, Doppler, ColorUltrasonography, Doppler, PulsedUltrasonography, PrenatalConceptsMiddle cerebral artery peak systolic velocityPeak systolic velocitySystolic velocityFetal anemiaGroup AAnemic fetusesMiddle cerebral artery peak systolic velocity valuesMiddle cerebral artery peak velocityFetal middle cerebral artery peak systolic velocityPeak systolic velocity valuesSystolic velocity valuesPeak velocityNormal mean valueAnemia riskNon-invasive methodGroup B.Prospective fashionFetal hematocritGroup BDoppler ultrasoundGroup CNormal fetusesAnemiaFetusesNormal valuesFifth digit measurement in normal pregnancies: a potential sonographic sign of Down's syndrome
Goldstein I, Gomez K, Copel J. Fifth digit measurement in normal pregnancies: a potential sonographic sign of Down's syndrome. Ultrasound In Obstetrics And Gynecology 1995, 5: 34-37. PMID: 7850587, DOI: 10.1046/j.1469-0705.1995.05010034.x.Peer-Reviewed Original ResearchConceptsGestational ageFifth fingerBiparietal diameterDown syndromeFemoral lengthHumeral lengthRoutine biometric measurementsNormal pregnancyWeeks' gestationStudy groupSonographic signsNormal fetusesSyndromePrenatal detectionFurther studiesGestationAgeNormative dataFetusesBiometric measurementsFingerLinear growthDigit measurementsPregnancy
1992
Fetuses with Down syndrome have disproportionately shortened frontal lobe dimensions on ultrasonographic examination
Bahado-Singh R, Wyse L, Dorr M, Copel J, O'Connor T, Hobbins J. Fetuses with Down syndrome have disproportionately shortened frontal lobe dimensions on ultrasonographic examination. American Journal Of Obstetrics And Gynecology 1992, 167: 1009-1014. PMID: 1415385, DOI: 10.1016/s0002-9378(12)80029-9.Peer-Reviewed Original ResearchConceptsDown syndrome fetusesSyndrome fetusesFrontothalamic distanceDown syndromePositive predictive valueWeeks' gestationGestational ageNormal medianPosterior thalamusUltrasonographic examinationGroup 52Normal fetusesFrontal lobePredictive valueInner tableFetusesFrontal boneMedianGestationMean valueSyndrome
1991
Foramen ovale size in the normal and abnormal human fetal heart: an indicator of transatrial flow physiology
Feit L, Copel J, Kleinman C. Foramen ovale size in the normal and abnormal human fetal heart: an indicator of transatrial flow physiology. Ultrasound In Obstetrics And Gynecology 1991, 1: 313-319. PMID: 12797035, DOI: 10.1046/j.1469-0705.1991.01050313.x.Peer-Reviewed Original ResearchHeart obstructive lesionsLeft heart obstructive lesionsObstructive lesionsColor Doppler studyDoppler studiesForamen ovaleColor flow Doppler studiesNormal cardiac anatomyCongenital heart diseaseRight ventricular developmentNormal flow patternsHuman fetal heartWeeks' gestationVentricular sizeDoppler interrogationFetal echocardiographyHeart diseaseAtrial septumHelpful adjunctNormal fetusesHuman fetusesFetal heartLesionsFetusesCardiac anatomyCardiac growth in fetuses of diabetic mothers with good metabolic control
Weber H, Copel J, Reece E, Green J, Kleinman C. Cardiac growth in fetuses of diabetic mothers with good metabolic control. The Journal Of Pediatrics 1991, 118: 103-107. PMID: 1986073, DOI: 10.1016/s0022-3476(05)81858-x.Peer-Reviewed Original ResearchConceptsGood metabolic controlVentricular diastolic dimensionDiabetic mothersDiastolic dimensionVentricular free wallFree wall ratioMetabolic controlNormal fetusesCardiac growthFetal weightGestational periodCardiac hypertrophyFree wallLeft ventricular diastolic dimensionRight ventricular diastolic dimensionRight ventricular free wallM-mode echocardiographic measurementsSimilar gestational ageStrict metabolic controlDaily glucose profilesM-mode measurementsGestational ageEchocardiographic measurementsInterventricular septumGlucose profiles
1988
Pulsed Doppler flow-velocity waveforms before and after intrauterine intravascular transfusion for severe erythroblastosis fetalis
Copel J, Grannum P, Belanger K, Green J, Hobbins J. Pulsed Doppler flow-velocity waveforms before and after intrauterine intravascular transfusion for severe erythroblastosis fetalis. American Journal Of Obstetrics And Gynecology 1988, 158: 768-774. PMID: 2966585, DOI: 10.1016/0002-9378(88)90070-1.Peer-Reviewed Original ResearchConceptsLate transfusionDoppler flow velocity waveformsIntrauterine intravascular transfusionFlow velocity waveformsSevere erythroblastosis fetalisFirst transfusionIntrauterine transfusionSubsequent transfusionsErythroblastosis fetalisIntravascular transfusionIsoimmunized pregnanciesDoppler studiesMaternal circulationDoppler ultrasoundTransfusionNormal fetusesHematocrit changesLack of changeHematocritDoppler parametersFetusesRapid volumeHydropsPregnancyFetalis